Reviewed, UniProtKB/Swiss-Prot P56116 (HTPG_HELPY)

Names and origin

Protein names

Recommended name:
    Chaperone protein htpG
Alternative name(s):
    Heat shock protein htpG
    High temperature protein G

Gene names

Name:	htpG
Ordered Locus Names:	HP_0210

Organism

Helicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]

Taxonomic identifier

210 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	621 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Molecular chaperone. Has ATPase activity By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the heat shock protein 90 family.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP unfolded protein binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 621	621	Chaperone protein htpG
Regions
	Region	1 – 341	341	A; substrate-binding By similarity
	Region	342 – 547	206	B By similarity
	Region	548 – 621	74	C By similarity

Sequences

	Sequence		Length	Mass (Da)
	P56116-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 28F198C1DC7EAB9A	FASTA	621	71,274
	10 20 30 40 50 60 MSNQEYTFQT EINQLLDLMI HSLYSNKEIF LRELVSNASD ALDKLNYLML TDEKLKGLNT 70 80 90 100 110 120 TPSIHLSFDS QKKTLTIKDN GIGMDKNDLI EHLGTIAKSG TKNFLSALSG DKKKDSALIG 130 140 150 160 170 180 QFGVGFYSAF MVASKIVVQT KKVNSDQAYA WVSDGKGKFE ISECVKDEQG TEITLFLKDE 190 200 210 220 230 240 DSHFASRWEI DSVVKKYSEH IPFPIFLTYT DTKHEGEGDN QKEIKEEKCE QINQASALWK 250 260 270 280 290 300 MNKSELKDKD YKEFYQSFAH DNSEPLSYIH NKVEGSLEYT TLFYIPSTAP FDMFRVDYKS 310 320 330 340 350 360 GVKLYVKRVF ITDDDKELLP SYLRFVKGVI DSEDLPLNVS REILQQNKIL ANIRSASVKK 370 380 390 400 410 420 ILSEIERLSK DEKNYHKFYE PFGKVLKEGL YGDFENKEKL LELLRFYSKD KEKLISLKEY 430 440 450 460 470 480 KENLKENQKS IYYLLGENLD LLKASPLLEK YAQKGYDVLL LSDEIDAFVM PGVNEYDKTP 490 500 510 520 530 540 FKDASHSESL KELGLEEIHD EVKDQFKDLM KAFEENLKDE IKGVELSSHL TSAVALIGDE 550 560 570 580 590 600 QNAMMANWMR QMGQSVPESK KTLELNPNHA ILQKLLKCED KEQLSAFIWL LYDGAKLLEK 610 620 GALKDAKSFN ERLNSVLLKA L

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000511 Genomic DNA. Translation: AAD07278.1.
PIR	B64546.
RefSeq	NP_207008.1.
3D structure databases
HSSP	HSSP built from PDB template 1YER based on UniProtKB P07900.
ModBase	Search...
Genome annotation databases
GeneID	900013.
GenomeReviews	Gene locus HP_0210 in contig AE000511_GR.
KEGG	hpy:HP0210.
NMPDR	fig|85962.1.peg.206.
TIGR	HP_0210.
Phylogenomic databases
HOGENOM	P56116.
Family and domain databases
HAMAP	MF_00505. [Tree]
InterPro	IPR003594. ATP_bd_ATPase. IPR001404. Hsp90. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit.
PANTHER	PTHR11528. Hsp90. 1 hit.
Pfam	PF02518. HATPase_c. 1 hit. PF00183. HSP90. 3 hits. [Graphical view]
PIRSF	PIRSF002583. Hsp90. 1 hit.
PRINTS	PR00775. HEATSHOCK90.
SMART	SM00387. HATPase_c. 1 hit. [Graphical view]
PROSITE	PS00298. HSP90. 1 hit. [Graphical view]
ProDom	P56116. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

HTPG_HELPY

Accession

Primary (citable) accession number: P56116

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	July 22, 2008
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)