Reviewed, UniProtKB/Swiss-Prot P56211 (ARP19_HUMAN)

Names and origin

Protein names

Recommended name:
    cAMP-regulated phosphoprotein 19
      Short name(s)=ARPP-19

Gene names

Name:

ARPP19

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	112 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May enhance GAP-43 expression by binding to the NGF-regulatory region of its mRNA By similarity.
Subcellular location	CytoplasmBy similarity.
Post-translational modification	Phosphorylated by PKA By similarity.
Sequence similarities	Belongs to the endosulfine family.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	positive regulation of gluconeogenesis Ref.1 Inferred from direct assay. Source: UniProtKB positive regulation of glucose import Ref.1 Non-traceable author statement. Source: UniProtKB
Molecular function	potassium channel regulator activity Ref.1 Inferred from direct assay. Source: UniProtKB receptor binding Ref.1 Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform ARPP-19 (identifier: P56211-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform ARPP-16 (identifier: P56211-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 112	111	cAMP-regulated phosphoprotein 19
Amino acid modifications
	Modified residue	2	1	N-acetylserine; in isoform ARPP-19 By similarity
	Modified residue	17	1	N-acetylmethionine; in isoform ARPP-16 By similarity
	Modified residue	62	1	Phosphoserine
	Modified residue	104	1	Phosphoserine; by PKA By similarity
Natural variations
	Alternative sequence	1 – 16	16	Missing in isoform ARPP-16.

Sequences

	Sequence		Length	Mass (Da)
	Isoform ARPP-19 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: F19652B545C839AB	FASTA	112	12,323
	10 20 30 40 50 60 MSAEVPEAAS AEEQKEMEDK VTSPEKAEEA KLKARYPHLG QKPGGSDFLR KRLQKGQKYF 70 80 90 100 110 DSGDYNMAKA KMKNKQLPTA APDKTEVTGD HIPTPQDLPQ RKPSLVASKL AG
	Isoform ARPP-16 [UniParc]. Checksum: E29FF03CFF5DB609		96	10,635
	10 20 30 40 50 60 MEDKVTSPEK AEEAKLKARY PHLGQKPGGS DFLRKRLQKG QKYFDSGDYN MAKAKMKNKQ 70 80 90 LPTAAPDKTE VTGDHIPTPQ DLPQRKPSLV ASKLAG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive K(ATP) channel: molecular cloning, expression and biological properties." Heron L., Virsolvy A., Peyrollier K., Gribble F.M., Le Cam A., Ashcroft F.M., Bataille D. Proc. Natl. Acad. Sci. U.S.A. 95:8387-8391(1998) [PubMed: 9653196] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ARPP-19). Tissue: Brain.
[2]	"Identification of okadaic-acid-induced genes by mRNA differential display in glioma cells." Chin L.S., Singh S.K., Wang Q., Murray S.F. J. Biomed. Sci. 7:152-159(2000) [PubMed: 10754390] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ARPP-19). Tissue: Brain.
[3]	"Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue." Brene S., Lindefors N., Ehrlich M., Taubes T., Horiuchi A., Kopp J., Hall H., Sedvall G., Greengard P., Persson H. J. Neurosci. 14:985-998(1994) [PubMed: 8120638] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ARPP-16). Tissue: Brain.
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ARPP-19).
[5]	The German cDNA consortium Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ARPP-19). Tissue: Spinal cord.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ARPP-19). Tissue: Placenta.
[7]	"Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line." Giorgianni F., Zhao Y., Desiderio D.M., Beranova-Giorgianni S. Electrophoresis 28:2027-2034(2007) [PubMed: 17487921] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62, MASS SPECTROMETRY.
[8]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62, MASS SPECTROMETRY. Tissue: Epithelium.
[9]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed: 18088087] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62, MASS SPECTROMETRY. Tissue: Platelet.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ223091 mRNA. Translation: CAA11115.1. AF084555 mRNA. Translation: AAD52044.1. CR457132 mRNA. Translation: CAG33413.1. AL833077 mRNA. Translation: CAD89929.1. BC003418 mRNA. Translation: AAH03418.1. BC100015 mRNA. Translation: AAI00016.1.
RefSeq	NP_006619.1.
UniGene	Hs.512908 Hs.639038
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	P56211.
Genome annotation databases
Ensembl	ENSG00000128989. Homo sapiens. [Contig view]
GeneID	10776.
KEGG	hsa:10776.
Organism-specific databases
H-InvDB	HIX0012254. HIX0030646. HIX0057640.
MIM	605487. gene.
GeneCards	Search...
Phylogenomic databases
HOGENOM	P56211.
HOVERGEN	P56211.
Gene expression databases
ArrayExpress	P56211.
GermOnline	ENSG00000128989. Homo sapiens.
Family and domain databases
InterPro	IPR006760. Endosulphine. [Graphical view]
Pfam	PF04667. Endosulfine. 1 hit. [Graphical view]
ProDom	P56211. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
LinkHub	P56211.
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

ARP19_HUMAN

Accession

Primary (citable) accession number: P56211
Secondary accession number(s): Q6IAM2, Q86TA6, Q9UD70

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 23, 2007
Last modified:	July 22, 2008
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)