Reviewed, UniProtKB/Swiss-Prot P57159 (ARLY_BUCAI)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	BU051

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (Acyrthosiphon pisum symbiotic bacterium) [Complete proteome] [HAMAP]

Taxonomic identifier

118099 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	459 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.
Subcellular location	CytoplasmProbable.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 459	459	Argininosuccinate lyase

Sequences

	Sequence		Length	Mass (Da)
	P57159-1 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: 0CF0A882CC6EDA8A	FASTA	459	52,378
	10 20 30 40 50 60 MGLWGGRFIN ESNKLFKEFN RSLSFDYILA EEDVISSVAW SKILMKSKII TEKEQITIES 70 80 90 100 110 120 ALFELLKEIK ENNQKILKSK CEDIHSWIEE KLIQKIGILG KKLHTGRSRN DQITTDLKLW 130 140 150 160 170 180 CRKKIHLLLE NIIELQKTFI LSAESNHNII MPGYTHLQRA QPITFSYWCL AYVEMFRRDF 190 200 210 220 230 240 SRLKDVLKRL NVSPLGSAAL SGTAWKINRE ELALSMGFDS ATNNALDTVS DRDYVVELLS 250 260 270 280 290 300 SASISMMHLS RFSEDIIFFN SGEADFIELS DTITSGSSLM PQKKNPDALE LIRAKCGRVH 310 320 330 340 350 360 GSLISILVIL KSLPLSYNKD MQEDKEGLFD SIKTWNDCLC MAILVLKNMQ IKNESCRKAA 370 380 390 400 410 420 EEGYSNATEI ADYLVKKGIA FREAHNISGQ LVLRAISEKK SLNELKLSVF QMYSNLIKND 430 440 450 IYKNITLESC LEKRMSKGGV APSQVYEEII KAKKRLNIF

References

[1]	"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS." Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H. Nature 407:81-86(2000) [PubMed: 10993077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tokyo 1998.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000003 Genomic DNA. Translation: BAB12774.1.
RefSeq	NP_239888.1.
3D structure databases
HSSP	HSSP built from PDB template 1AOS based on UniProtKB P04424.
ModBase	Search...
Genome annotation databases
GeneID	1109458.
GenomeReviews	Gene locus BU051 in contig BA000003_GR.
KEGG	buc:BU051.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P57159.
Enzyme and pathway databases
BioCyc	BSP107806:BU051-MON.
Family and domain databases
HAMAP	MF_00006. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. DCRYSTALLIN. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProDom	P57159. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ARLY_BUCAI

Accession

Primary (citable) accession number: P57159

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	September 2, 2008
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)