Reviewed, UniProtKB/Swiss-Prot P61700 (SYA_DESVH)

Names and origin

Protein names

Recommended name:
    Alanyl-tRNA synthetase
    EC=6.1.1.7
Alternative name(s):
    Alanine--tRNA ligase
      Short name(s)=AlaRS

Gene names

Name:	alaS
Ordered Locus Names:	DVU_1089

Organism

Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303) [Complete proteome] [HAMAP]

Taxonomic identifier

882 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio

Protein attributes

Sequence length	879 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	alanyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP alanine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 879	879	Alanyl-tRNA synthetase

Sequences

	Sequence		Length	Mass (Da)
	P61700-1 [UniParc]. Last modified June 7, 2004. Version 1. Checksum: FD8FD0E73E4D5E77	FASTA	879	96,926
	10 20 30 40 50 60 MITANEIRRR FLEFYKAHGH EAVRSSSLVP KDDPSLLFTN AGMVQFKKIF LGQEKRAYSR 70 80 90 100 110 120 ATTSQKCLRV GGKHNDLENV GRTARHHTFF EMLGNFSFGD YFKEDAIKFA WKFLTEELKL 130 140 150 160 170 180 PKERLYATVF RDDDEAEQLW LKHSDIPAER IYRMGEKDNF WSMGDTGPCG PCSEILIDQG 190 200 210 220 230 240 EHMTCGPDCG IGKCDCDRFL EIWNLVFMQY DQDATGKREP LPKPSIDTGM GLERITAVCQ 250 260 270 280 290 300 GVFSNFDTDI FQAIIQYTCG LANVSYRSDD ETDTALRVIA DHSRAIAFMI TDGILPSNEG 310 320 330 340 350 360 RGYVLRRLIR RAYRFGRLIG LTDTFLHKTA LKVVDIMGDD YPELRENSDF MARVVREEED 370 380 390 400 410 420 RFNRTLDKGL SMLEDELATL SASGAAHVPG DIAFRLYDTF GFPLDIVNDI AEKRGFSVDE 430 440 450 460 470 480 DGFKALMKEQ KERAKAAWKG SGEKDIASRF QPLLEEGMRS EFIGYDHLCG EGRIVALMDE 490 500 510 520 530 540 HALAVERLAA GQKGYLVTNR TPFYGASGGQ SGDIGTIASP SGKVRVVDTI KPSPELVVHH 550 560 570 580 590 600 VEAVEGDILL DQEVDLTVTE DDRVASARNH TCTHLLHAAL RRVLGDHVKQ AGSLVAPDRL 610 620 630 640 650 660 RFDFTHIAPM TPEELAAVER EVNRVIMADI PLETDHMHYD DAVKRGAMAL FGEKYGDEVR 670 680 690 700 710 720 VVAIADESVE LCGGTHLRAT GQAGLFLIVS ESGVAAGVRR IEALTGWNAM HAVLAQRSEQ 730 740 750 760 770 780 AQLSAMLKAR PGEIVSRVES LQKENRTLRK DMERAAAQAT SGQGRNIMDE ATDVAGVKLL 790 800 810 820 830 840 AAKVEVPNVK ALRDLMDDVR SKLVSGIACL AAVDGDKVQL IIAVSKDLQT RFTAPQLIKD 850 860 870 VAAEVGGSGG GRPDMAQAGG TNPAGIDAAF AKLRSLIGG

References

[1]

"The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough." Heidelberg J.F., Seshadri R., Haveman S.A., Hemme C.L., Paulsen I.T., Kolonay J.F., Eisen J.A., Ward N.L., Methe B.A., Brinkac L.M., Daugherty S.C., DeBoy R.T., Dodson R.J., Durkin A.S., Madupu R., Nelson W.C., Sullivan S.A., Fouts D.E. , Haft D.H., Selengut J., Peterson J.D., Davidsen T.M., Zafar N., Zhou L., Radune D., Dimitrov G., Hance M., Tran K., Khouri H.M., Gill J., Utterback T.R., Feldblyum T.V., Wall J.D., Voordouw G., Fraser C.M. Nat. Biotechnol. 22:554-559(2004) [PubMed: 15077118] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017285 Genomic DNA. Translation: AAS95569.1.
RefSeq	YP_010310.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2794068.
GenomeReviews	Gene locus DVU_1089 in contig AE017285_GR.
KEGG	dvu:DVU1089.
NMPDR	fig|882.1.peg.1085.
TIGR	DVU_1089.
Phylogenomic databases
HOGENOM	P61700.
Enzyme and pathway databases
BioCyc	DVUL882:DVU_1089-MON.
Family and domain databases
HAMAP	MF_00036. [Tree]
InterPro	IPR002318. Ala-tRNA-synth_IIc. IPR003156. Pesterase_DHHA1. IPR012947. tRNA_SAD. [Graphical view]
Pfam	PF02272. DHHA1. 1 hit. PF01411. tRNA-synt_2c. 1 hit. PF07973. tRNA_SAD. 1 hit. [Graphical view]
PRINTS	PR00980. TRNASYNTHALA.
TIGRFAMs	TIGR00344. alaS. 1 hit.
PROSITE	PS50860. AA_TRNA_LIGASE_II_ALA. 1 hit. [Graphical view]
ProDom	P61700. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

SYA_DESVH

Accession

Primary (citable) accession number: P61700

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	June 7, 2004
Last modified:	July 22, 2008
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)