Reviewed, UniProtKB/Swiss-Prot P62679 (MTB_CHIRA)

Names and origin

Protein names

Recommended name:
    Metallothionein B
      Short name(s)=MT-B, MT-II

Gene names

Name:

mtb

Organism

Chionodraco rastrospinosus (Ocellated icefish)

Taxonomic identifier

34790 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Perciformes › Notothenioidei › Channichthyidae › Chionodraco

Protein attributes

Sequence length	60 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Metallothioneins have a high content of cysteine residues that bind various heavy metals By similarity.
Domain	Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence similarities	Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
Ligand	Metal-binding Metal-thiolate cluster
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 60	60	Metallothionein B
Regions
	Region	1 – 28	28	Beta
	Region	29 – 60	32	Alpha
Sites
	Metal binding	4	1	Cluster B
	Metal binding	6	1	Cluster B
	Metal binding	12	1	Cluster B
	Metal binding	14	1	Cluster B
	Metal binding	18	1	Cluster B
	Metal binding	20	1	Cluster B
	Metal binding	23	1	Cluster B
	Metal binding	25	1	Cluster B
	Metal binding	28	1	Cluster B
	Metal binding	32	1	Cluster A
	Metal binding	33	1	Cluster A
	Metal binding	35	1	Cluster A
	Metal binding	36	1	Cluster A
	Metal binding	40	1	Cluster A
	Metal binding	43	1	Cluster A
	Metal binding	47	1	Cluster A
	Metal binding	49	1	Cluster A
	Metal binding	54	1	Cluster A
	Metal binding	58	1	Cluster A
	Metal binding	59	1	Cluster A

Sequences

	Sequence		Length	Mass (Da)
	P62679-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: E866F4AD61BC424A	FASTA	60	5,992
	10 20 30 40 50 60 MDPCECSKSG TCNCGGSCTC TNCSCTSCKK SCCPCCPSGC TKCASGCVCK GKTCDTSCCQ

References

[1]

"Difference in hepatic metallothionein content in Antarctic red-blooded and haemoglobinless fish: undetectable metallothionein levels in haemoglobinless fish is accompanied by accumulation of untranslated metallothionein mRNA." Scudiero R., Carginale V., Riggio M., Capasso C., Capasso A., Kille P., di Prisco G., Parisi E. Biochem. J. 322:207-211(1997) [PubMed: 9078263] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z72484 mRNA. Translation: CAA96565.1.
3D structure databases
HSSP	HSSP built from PDB template 1M0G based on UniProtKB O73914.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P62679.
Family and domain databases
InterPro	IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. [Graphical view]
Gene3D	G3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHER	PTHR23299. Metallothionein_vert. 1 hit.
Pfam	PF00131. Metallothio. 1 hit. [Graphical view]
PRINTS	PR00860. MTVERTEBRATE.
PROSITE	PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view]
ProDom	P62679. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

MTB_CHIRA

Accession

Primary (citable) accession number: P62679
Secondary accession number(s): Q92145

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	July 22, 2008
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)