Reviewed, UniProtKB/Swiss-Prot P62740 (ACTA_RABIT)

Names and origin

Protein names

Actin, aortic smooth muscle
Also known as:
     Alpha-actin-2

Gene names

Name:	ACTA2
Synonyms:	ACTSA, ACTVS

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein existence

Evidence at protein level.

General annotation (Comments)

Function	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Subunit structure	Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
Subcellular location	Cytoplasm, cytoskeleton.
Miscellaneous	In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
Sequence similarities	Belongs to the actin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Ligand	ATP-binding Nucleotide-binding
Molecular function	Muscle protein Structural protein
PTM	Acetylation Methylation
Gene Ontology (GO)
Molecular function	protein binding Inferred from physical interaction. Source: UniProtKB structural constituent of cytoskeleton Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
stg1	O14185	2	EBI-875232,EBI-875219	From a different organism.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Propeptide	1 – 2	2	Removed in mature form By similarity
	Chain	3 – 377	375	Actin, aortic smooth muscle
Amino acid modifications
	Modified residue	3	1	N-acetylglutamate By similarity
	Modified residue	75	1	Tele-methylhistidine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P62740-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 2D0543262DB35CA5	FASTA	377	42,009
	10 20 30 40 50 60 MCEEEDSTAL VCDNGSGLCK AGFAGDDAPR AVFPSIVGRP RHQGVMVGMG QKDSYVGDEA 70 80 90 100 110 120 QSKRGILTLK YPIEHGIITN WDDMEKIWHH SFYNELRVAP EEHPTLLTEA PLNPKANREK 130 140 150 160 170 180 MTQIMFETFN VPAMYVAIQA VLSLYASGRT TGIVLDSGDG VTHNVPIYEG YALPHAIMRL 190 200 210 220 230 240 DLAGRDLTDY LMKILTERGY SFVTTAEREI VRDIKEKLCY VALDFENEMA TAASSSSLEK 250 260 270 280 290 300 SYELPDGQVI TIGNERFRCP ETLFQPSFIG MESAGIHETT YNSIMKCDID IRKDLYANNV 310 320 330 340 350 360 LSGGTTMYPG IADRMQKEIT ALAPSTMKIK IIAPPERKYS VWIGGSILAS LSTFQQMWIS 370 KQEYDEAGPS IVHRKCF

References

[1]	"Nucleotide sequences of the rabbit alpha-smooth-muscle and beta-non-muscle actin mRNAs." Harris D.E., Warshaw D.M., Periasamy M. Gene 112:265-266(1992) [PubMed: 1555776] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: New Zealand white. Tissue: Uterus.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X60732 mRNA. Translation: CAA43139.1.
PIR	ATRBSM. JH0636.
RefSeq	NP_001095152.1.
UniGene	Ocu.2090
3D structure databases
SMR	P62740. Positions 6-373.
ModBase	Search...
Protein-protein interaction databases
IntAct	P62740.
Genome annotation databases
Ensembl	ENSOCUG00000004074. Oryctolagus cuniculus. [Contig view]
GeneID	100009271.
Phylogenomic databases
HOVERGEN	P62740.
Family and domain databases
InterPro	IPR004001. Actin_CS. IPR004000. Actin_like. [Graphical view]
PANTHER	PTHR11937. Actin_like. 1 hit.
Pfam	PF00022. Actin. 1 hit. [Graphical view]
PRINTS	PR00190. ACTIN.
SMART	SM00268. ACTIN. 1 hit. [Graphical view]
PROSITE	PS00406. ACTINS_1. 1 hit. PS00432. ACTINS_2. 1 hit. PS01132. ACTINS_ACT_LIKE. 1 hit. [Graphical view]
ProDom	P62740. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ACTA_RABIT

Accession

Primary (citable) accession number: P62740
Secondary accession number(s): P03996, P04108

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 1986
Last sequence update:	August 16, 2004
Last modified:	June 10, 2008
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)