Reviewed, UniProtKB/Swiss-Prot P67982 (MT1A_SHEEP)

Names and origin

Protein names

Recommended name:
    Metallothionein-1A
      Short name=MT-1A
Alternative name(s):
    Metallothionein-IA
      Short name=MT-IA
    MTC

Gene names

Name:	MT1A
Synonyms:	MT-IA

Organism

Ovis aries (Sheep)

Taxonomic identifier

9940 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis

Protein attributes

Sequence length	61 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Subunit structure	Monomer.
Domain	Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence similarities	Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
Ligand	Metal-binding Metal-thiolate cluster
PTM	Acetylation
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 61	61	Metallothionein-1A
Regions
	Region	1 – 29	29	Beta
	Region	30 – 61	32	Alpha
Sites
	Metal binding	5	1	Cluster B
	Metal binding	7	1	Cluster B
	Metal binding	13	1	Cluster B
	Metal binding	15	1	Cluster B
	Metal binding	19	1	Cluster B
	Metal binding	21	1	Cluster B
	Metal binding	24	1	Cluster B
	Metal binding	26	1	Cluster B
	Metal binding	29	1	Cluster B
	Metal binding	33	1	Cluster A
	Metal binding	34	1	Cluster A
	Metal binding	36	1	Cluster A
	Metal binding	37	1	Cluster A
	Metal binding	41	1	Cluster A
	Metal binding	44	1	Cluster A
	Metal binding	48	1	Cluster A
	Metal binding	50	1	Cluster A
	Metal binding	57	1	Cluster A
	Metal binding	59	1	Cluster A
	Metal binding	60	1	Cluster A
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P67982-1 [UniParc]. Last modified August 13, 1987. Version 1. Checksum: CB56570A19BC6995	FASTA	61	5,951
	10 20 30 40 50 60 MDPNCSCPTG GSCSCAGSCT CKACRCPSCK KSCCSCCPVG CAKCAQGCVC KGASDKCSCC A

References

[1]	"Cloning and sequencing of a sheep metallothionein cDNA." Peterson M.G., Lazdins I., Danks D.M., Mercer J.F.B. Eur. J. Biochem. 143:507-511(1984) [PubMed: 6434305] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Structure and regulation of the sheep metallothionein-Ia gene." Peterson M.G., Mercer J.F.B. Eur. J. Biochem. 160:579-585(1986) [PubMed: 3780723] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	X00953 mRNA. Translation: CAA25464.1. X04626 Genomic DNA. Translation: CAA28299.1.
PIR	SMBO2. A03279. S00808.
3D structure databases
HSSP	HSSP built from PDB template 1MHU based on UniProtKB P02795.
SMR	P67982. Positions 1-61.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P67982.
Family and domain databases
InterPro	IPR002400. GF_cysknot. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. [Graphical view]
Gene3D	G3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHER	PTHR23299. Metallothionein_vert. 1 hit.
Pfam	PF00131. Metallothio. 1 hit. [Graphical view]
PRINTS	PR00438. GFCYSKNOT. PR00860. MTVERTEBRATE.
PROSITE	PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view]
ProDom	P67982. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

MT1A_SHEEP

Accession

Primary (citable) accession number: P67982
Secondary accession number(s): P04356, P04902

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
Last sequence update:	August 13, 1987
Last modified:	July 22, 2008
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)