Reviewed, UniProtKB/Swiss-Prot P68506 (MTA_CHIHA)

Names and origin

Protein names

Recommended name:
    Metallothionein A
      Short name=MT-A
      Short name=MT-I

Gene names

Name:

mta

Organism

Chionodraco hamatus (Antarctic teleost icefish)

Taxonomic identifier

36188 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Perciformes › Notothenioidei › Channichthyidae › Chionodraco

Protein attributes

Sequence length	60 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Metallothioneins have a high content of cysteine residues that bind various heavy metals By similarity.
Domain	Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence similarities	Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
Ligand	Metal-binding Metal-thiolate cluster Zinc
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 60	60	Metallothionein A
Regions
	Region	1 – 28	28	Beta
	Region	29 – 60	32	Alpha
Sites
	Metal binding	4	1	Cluster B By similarity
	Metal binding	6	1	Cluster B By similarity
	Metal binding	12	1	Cluster B By similarity
	Metal binding	14	1	Cluster B By similarity
	Metal binding	18	1	Cluster B By similarity
	Metal binding	20	1	Cluster B By similarity
	Metal binding	23	1	Cluster B By similarity
	Metal binding	25	1	Cluster B By similarity
	Metal binding	28	1	Cluster B By similarity
	Metal binding	32	1	Cluster A By similarity
	Metal binding	33	1	Cluster A By similarity
	Metal binding	35	1	Cluster A By similarity
	Metal binding	36	1	Cluster A By similarity
	Metal binding	40	1	Cluster A By similarity
	Metal binding	43	1	Cluster A By similarity
	Metal binding	47	1	Cluster A By similarity
	Metal binding	49	1	Cluster A By similarity
	Metal binding	54	1	Cluster A By similarity
	Metal binding	58	1	Cluster A By similarity
	Metal binding	59	1	Cluster A By similarity

Sequences

	Sequence		Length	Mass (Da)
	P68506-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 5966E6145A2C424B	FASTA	60	6,005
	10 20 30 40 50 60 MDPCDCSKSG TCNCGGSCTC TNCSCKSCKK SCCPCCPSGC TKCASGCVCK GKTCDTSCCQ

References

[1]

"Cadmium-induced differential accumulation of metallothionein isoforms in the Antarctic icefish, which exhibits no basal metallothionein protein but high endogenous mRNA levels." Carginale V., Scudiero R., Capasso C., Capasso A., Kille P., di Prisco G., Parisi E. Biochem. J. 332:475-481(1998) [PubMed: 9601077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y12580 mRNA. Translation: CAA73159.1.
3D structure databases
HSSP	HSSP built from PDB template 1M0G based on UniProtKB O73914.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P68506.
Family and domain databases
InterPro	IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. [Graphical view]
Gene3D	G3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHER	PTHR23299. Metallothionein_vert. 1 hit.
Pfam	PF00131. Metallothio. 1 hit. [Graphical view]
PRINTS	PR00860. MTVERTEBRATE.
PROSITE	PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view]
ProDom	P68506. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

MTA_CHIHA

Accession

Primary (citable) accession number: P68506
Secondary accession number(s): O13258

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	November 23, 2004
Last modified:	July 22, 2008
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)