Reviewed, UniProtKB/Swiss-Prot P80290 (MT2C_RABIT)

Names and origin

Protein names	Recommended name:     Metallothionein-2C       Short name(s)=MT-2C Alternative name(s):     Metallothionein-IIC       Short name(s)=MT-IIC
Organism	Oryctolagus cuniculus (Rabbit)
Taxonomic identifier	9986 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	62 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Subunit structure	Monomer.
Domain	Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence similarities	Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
Ligand	Cadmium Copper Metal-binding Metal-thiolate cluster Zinc
PTM	Acetylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 62	62	Metallothionein-2C
Regions
	Region	1 – 30	30	Beta
	Region	31 – 62	32	Alpha
Sites
	Metal binding	5	1	Cluster B
	Metal binding	7	1	Cluster B
	Metal binding	14	1	Cluster B
	Metal binding	16	1	Cluster B
	Metal binding	20	1	Cluster B
	Metal binding	22	1	Cluster B
	Metal binding	25	1	Cluster B
	Metal binding	27	1	Cluster B
	Metal binding	30	1	Cluster B
	Metal binding	34	1	Cluster A
	Metal binding	35	1	Cluster A
	Metal binding	37	1	Cluster A
	Metal binding	38	1	Cluster A
	Metal binding	42	1	Cluster A
	Metal binding	45	1	Cluster A
	Metal binding	49	1	Cluster A
	Metal binding	51	1	Cluster A
	Metal binding	58	1	Cluster A
	Metal binding	60	1	Cluster A
	Metal binding	61	1	Cluster A
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine

Sequences

	Sequence		Length	Mass (Da)
	P80290-1 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: D6EBA7B70112AB3E	FASTA	62	6,113
	10 20 30 40 50 60 MDPNCSCATA GDSCTCANSC TCKACKCTSC KKSCCSCCPP GCAKCAQGCI CKGASDKCSC CA

References

[1]	"Primary structures of seven metallothioneins from rabbit tissue." Hunziker P.E., Kaur P., Wan M., Kaenzig A. Biochem. J. 306:265-270(1995) [PubMed: 7864820] [Abstract] Cited for: PROTEIN SEQUENCE. Strain: New Zealand white. Tissue: Kidney and Liver.

Cross-references

Sequence databases
PIR	A37425. S54335.
3D structure databases
HSSP	HSSP built from PDB template 1MRB based on UniProtKB P18055.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P80290.
Family and domain databases
InterPro	IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. [Graphical view]
Gene3D	G3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHER	PTHR23299. Metallothionein_vert. 1 hit.
Pfam	PF00131. Metallothio. 1 hit. [Graphical view]
PRINTS	PR00860. MTVERTEBRATE.
PROSITE	PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view]
ProDom	P80290. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

MT2C_RABIT

Accession

Primary (citable) accession number: P80290

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	July 22, 2008
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)