Reviewed, UniProtKB/Swiss-Prot P80294 (MT1H_HUMAN)

Names and origin

Protein names

Recommended name:
    Metallothionein-1H
      Short name=MT-1H
Alternative name(s):
    Metallothionein-IH
      Short name=MT-IH
    Metallothionein-0
      Short name=MT-0

Gene names

Name:

MT1H

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	61 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Subunit structure	Monomer.
Domain	Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence similarities	Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
Ligand	Cadmium Copper Metal-binding Metal-thiolate cluster Zinc
PTM	Acetylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular function	protein binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SPINK7	P58062	3	EBI-296567,EBI-1182445

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 61	61	Metallothionein-1H
Regions
	Region	1 – 29	29	Beta
	Region	30 – 61	32	Alpha
Sites
	Metal binding	5	1	Cluster B
	Metal binding	7	1	Cluster B
	Metal binding	13	1	Cluster B
	Metal binding	15	1	Cluster B
	Metal binding	19	1	Cluster B
	Metal binding	21	1	Cluster B
	Metal binding	24	1	Cluster B
	Metal binding	26	1	Cluster B
	Metal binding	29	1	Cluster B
	Metal binding	33	1	Cluster A
	Metal binding	34	1	Cluster A
	Metal binding	36	1	Cluster A
	Metal binding	37	1	Cluster A
	Metal binding	41	1	Cluster A
	Metal binding	44	1	Cluster A
	Metal binding	48	1	Cluster A
	Metal binding	50	1	Cluster A
	Metal binding	57	1	Cluster A
	Metal binding	59	1	Cluster A
	Metal binding	60	1	Cluster A
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine

Sequences

	Sequence		Length	Mass (Da)
	P80294-1 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 03D866E4F437A2CC	FASTA	61	6,039
	10 20 30 40 50 60 MDPNCSCEAG GSCACAGSCK CKKCKCTSCK KSCCSCCPLG CAKCAQGCIC KGASEKCSCC A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Hunziker P.E. Submitted (NOV-1993) to UniProtKB Cited for: PROTEIN SEQUENCE. Tissue: Liver.
[2]	"Cloning and specific polymerised-chain-reaction amplification of a third charge-separable human metallothionein isoform." Soumillion A., van Damme J., de Ley M. Eur. J. Biochem. 209:999-1004(1992) [PubMed: 1425708] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 3-22. Tissue: Embryonic liver.
[3]	"Characterisation of six additional human metallothionein genes." Stennard F.A., Holloway A.F., Hamilton J., West A.K. Biochim. Biophys. Acta 1218:357-365(1994) [PubMed: 8049263] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas and Prostate.
[6]	"Induction by zinc of specific metallothionein isoforms in human monocytes." Pauwels M., van Weyenbergh J., Soumillion A., Proost P., Ley M. Eur. J. Biochem. 220:105-110(1994) [PubMed: 8119276] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-31, PROTEIN SEQUENCE OF 1-30. Tissue: Monocyte.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X64834 Genomic DNA. Translation: CAA46046.1. X64177 mRNA. Translation: CAA45516.1. BT007171 mRNA. Translation: AAP35835.1. BC008408 mRNA. Translation: AAH08408.1. BC059780 mRNA. Translation: AAH59780.1. S68948 mRNA. Translation: AAB30081.1.
PIR	S47651.
RefSeq	NP_005942.1.
UniGene	Hs.438462 Hs.632513
3D structure databases
HSSP	HSSP built from PDB template 1MHU based on UniProtKB P02795.
SMR	P80294. Positions 1-61.
ModBase	Search...
Protein-protein interaction databases
IntAct	P80294.
Genome annotation databases
Ensembl	ENSG00000205358. Homo sapiens. [Contig view]
GeneID	4496.
KEGG	hsa:4496.
Organism-specific databases
H-InvDB	HIX0013058. HIX0028598.
HGNC	HGNC:7400. MT1H.
MIM	156354. gene.
PharmGKB	PA31205.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P80294.
HOVERGEN	P80294.
Gene expression databases
ArrayExpress	P80294.
CleanEx	HS_MT1H.
GermOnline	ENSG00000205358. Homo sapiens.
Family and domain databases
InterPro	IPR002400. GF_cysknot. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. [Graphical view]
Gene3D	G3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHER	PTHR23299. Metallothionein_vert. 1 hit.
Pfam	PF00131. Metallothio. 1 hit. [Graphical view]
PRINTS	PR00438. GFCYSKNOT. PR00860. MTVERTEBRATE.
PROSITE	PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view]
ProDom	P80294. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

MT1H_HUMAN

Accession

Primary (citable) accession number: P80294

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	September 2, 2008
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)