Reviewed, UniProtKB/Swiss-Prot P80297 (MT1X_HUMAN)

Names and origin

Protein names

Recommended name:
    Metallothionein-1X
      Short name=MT-1X
Alternative name(s):
    Metallothionein-IX
      Short name=MT-IX

Gene names

Name:

MT1X

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	61 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Subunit structure	Monomer.
Domain	Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence similarities	Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
Ligand	Cadmium Copper Metal-binding Metal-thiolate cluster Zinc
PTM	Acetylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	response to metal ion Traceable author statement. Source: ProtInc
Molecular function	metal ion binding Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 61	61	Metallothionein-1X
Regions
	Region	1 – 29	29	Beta
	Region	30 – 61	32	Alpha
Sites
	Metal binding	5	1	Cluster B
	Metal binding	7	1	Cluster B
	Metal binding	13	1	Cluster B
	Metal binding	15	1	Cluster B
	Metal binding	19	1	Cluster B
	Metal binding	21	1	Cluster B
	Metal binding	24	1	Cluster B
	Metal binding	26	1	Cluster B
	Metal binding	29	1	Cluster B
	Metal binding	33	1	Cluster A
	Metal binding	34	1	Cluster A
	Metal binding	36	1	Cluster A
	Metal binding	37	1	Cluster A
	Metal binding	41	1	Cluster A
	Metal binding	44	1	Cluster A
	Metal binding	48	1	Cluster A
	Metal binding	50	1	Cluster A
	Metal binding	57	1	Cluster A
	Metal binding	59	1	Cluster A
	Metal binding	60	1	Cluster A
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine

Sequences

	Sequence		Length	Mass (Da)
	P80297-1 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 381966F942E986B2	FASTA	61	6,068
	10 20 30 40 50 60 MDPNCSCSPV GSCACAGSCK CKECKCTSCK KSCCSCCPVG CAKCAQGCIC KGTSDKCSCC A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Soumillion A., van Weyenbergh J., de Ley M. Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	Hunziker P.E. Submitted (NOV-1993) to UniProtKB Cited for: PROTEIN SEQUENCE. Tissue: Liver.
[3]	"Characterisation of six additional human metallothionein genes." Stennard F.A., Holloway A.F., Hamilton J., West A.K. Biochim. Biophys. Acta 1218:357-365(1994) [PubMed: 8049263] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[5]	"Induction by zinc of specific metallothionein isoforms in human monocytes." Pauwels M., van Weyenbergh J., Soumillion A., Proost P., Ley M. Eur. J. Biochem. 220:105-110(1994) [PubMed: 8119276] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-31.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X76717 mRNA. Translation: CAA54136.1. X65607 Genomic DNA. Translation: CAA46557.1. BC032338 mRNA. Translation: AAH32338.1. S68956 mRNA. Translation: AAB30084.1.
PIR	S47652.
RefSeq	NP_005943.1.
UniGene	Hs.374950
3D structure databases
HSSP	HSSP built from PDB template 1MHU based on UniProtKB P02795.
SMR	P80297. Positions 1-61.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000187193. Homo sapiens. [Contig view]
GeneID	4501.
KEGG	hsa:4501.
Organism-specific databases
H-InvDB	HIX0021646.
HGNC	HGNC:7405. MT1X.
MIM	156359. gene.
PharmGKB	PA31213.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P80297.
HOVERGEN	P80297.
Gene expression databases
ArrayExpress	P80297.
CleanEx	HS_MT1X.
GermOnline	ENSG00000187193. Homo sapiens.
Family and domain databases
InterPro	IPR002400. GF_cysknot. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. [Graphical view]
Gene3D	G3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHER	PTHR23299. Metallothionein_vert. 1 hit.
Pfam	PF00131. Metallothio. 1 hit. [Graphical view]
PRINTS	PR00438. GFCYSKNOT. PR00860. MTVERTEBRATE.
PROSITE	PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view]
ProDom	P80297. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
LinkHub	P80297.
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

MT1X_HUMAN

Accession

Primary (citable) accession number: P80297

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	July 22, 2008
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)