Reviewed, UniProtKB/Swiss-Prot P81214 (CARP_SYNRA)

Names and origin

Protein names

Recommended name:
    Syncephapepsin
    EC=3.4.23.-

Gene names

Name:

SPSR

Organism

Syncephalastrum racemosum

Taxonomic identifier

13706 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Fungi incertae sedis › Basal fungal lineages › Mucoromycotina › Mucorales › Syncephalastraceae › Syncephalastrum

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Hydrolysis of proteins with a broad specificity. Residues recognized to be cleaved were primarily those of trypsin and chymotrypsin and Lys was the most susceptible.
Subunit structure	Monomer.
Sequence similarities	Belongs to the peptidase A1 family.

Ontologies

Keywords
Domain	Signal
Molecular function	Aspartyl protease Hydrolase Protease
PTM	Zymogen
Technical term	Direct protein sequencing
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Propeptide	20 – 71	52	Activation peptide Potential
	Chain	72 – 395	324	Syncephapepsin
Sites
	Active site	107	1	By similarity
	Active site	288	1	By similarity
Amino acid modifications
	Disulfide bond	120 ↔ 123
	Disulfide bond	322 ↔ 355

Sequences

	Sequence		Length	Mass (Da)
	P81214-1 [UniParc]. Last modified July 15, 1999. Version 1. Checksum: C4B3AFFD79B03D16	FASTA	395	41,388
	10 20 30 40 50 60 MKFSLALLAT VALATISQAA PVEKQVAGKP FQLVKNPHYQ ANATRAIFRA EKKYARHTAI 70 80 90 100 110 120 PEQGKTIVKS AASGTGSVPM TDVDYDVEYY ATVSVGTPAQ SIKLDFDTGS SDLWFSSTLC 130 140 150 160 170 180 TSCGSKSFDP TKSSTYKKVG KSWQISYGDG SSASGITATD NVELGGLKIT GQTIELATRE 190 200 210 220 230 240 SSSFSSGAID GILGLGFDTI STVAGTKTPV DNLISQNLIS KPIFGVWLGK QSEGGGGEYV 250 260 270 280 290 300 FGGYNTDHID GSLTTVKVDN SQGWYGVTVS GLKVGSKSVA SSFDGILDTG TTLLIFDQAT 310 320 330 340 350 360 GSKVAAAYGA KDNGDGTYTI SCDQSKLQPL ALTMGGKDFF VPADSLIYVK QGSQCIAGFG 370 380 390 YSSMDFAIIG DTFLKNNYVV FNQGVPEVQI APSKA

References

[1]	"Amino-acid sequence and gene cloning of syncephapepsin from Syncephalastrum racemosum." Ho H.-C., Shiau P.-F., Liao J.-M., Chung J.-G. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE OF 72-395.
[2]	"Identification of a fungal protein of Syncephalastrum racemosum as aspartic proteinase." Ho H.-C., Chen L.-Y., Liao T.H. Arch. Biochem. Biophys. 334:97-103(1996) [PubMed: 8837744] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE.
[3]	"Single-column purification of syncephapepsin -- an aspartic proteinase from Syncephalastrum racemosum." Ho H.-C., Shiau P.F., Wu S.L. Protein Expr. Purif. 12:399-403(1998) [PubMed: 9535708] [Abstract] Cited for: CHARACTERIZATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF043552 mRNA. Translation: AAC69517.1.
3D structure databases
HSSP	HSSP built from PDB template 2APR based on UniProtKB P06026.
ModBase	Search...
Protein family/group databases
MEROPS	A01.042.
Family and domain databases
InterPro	IPR001969. Pept_Asp_AS. IPR009007. Pept_Aspartc_cat. IPR001461. Peptidase_A1. [Graphical view]
Gene3D	G3DSA:2.40.70.10. Pept_Aspartc_cat. 1 hit.
PANTHER	PTHR13683. Peptidase_A1. 1 hit.
Pfam	PF00026. Asp. 1 hit. [Graphical view]
PRINTS	PR00792. PEPSIN.
PROSITE	PS00141. ASP_PROTEASE. 2 hits. [Graphical view]
ProDom	P81214. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

CARP_SYNRA

Accession

Primary (citable) accession number: P81214

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	July 15, 1999
Last modified:	July 22, 2008
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)