Reviewed, UniProtKB/Swiss-Prot P83968 (ACT6_DROSI)

Names and origin

Protein names

Recommended name:
    Actin, indirect flight muscle
Alternative name(s):
    Actin-88F

Gene names

Name:

Act88F

Organism

Drosophila simulans (Fruit fly)

Taxonomic identifier

7240 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.
Subcellular location	Cytoplasm › cytoskeleton.
Miscellaneous	In Drosophila there are 6 closely related actin genes.
Sequence similarities	Belongs to the actin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Ligand	ATP-binding Nucleotide-binding
Molecular function	Muscle protein Structural protein
PTM	Acetylation
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Propeptide	1 – 2	2	Removed in mature form By similarity
	Chain	3 – 376	374	Actin, indirect flight muscle
Amino acid modifications
	Modified residue	3	1	N-acetylaspartate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P83968-1 [UniParc]. Last modified June 7, 2004. Version 1. Checksum: C64C33A1674B7886	FASTA	376	41,700
	10 20 30 40 50 60 MCDDDAGALV IDNGSGMCKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ KDSYVGDEAQ 70 80 90 100 110 120 SKRGILTLKY PIEHGIITNW DDMEKIWHHT FYNELRVAPE EHPVLLTEAP LNPKANREKM 130 140 150 160 170 180 TQIMFETFNS PAMYVAIQAV LSLYASGRTT GIVLDSGDGV SHTVPIYEGF ALPHAILRLD 190 200 210 220 230 240 LAGRDLTDYL MKILTERGYS FTTTAEREIV RDIKEKLCYV ALDFEQEMAT AAASTSLEKS 250 260 270 280 290 300 YELPDGQVIT IGNERFRCPE ALFQPSFLGM ESCGIHETVY NSIMKCDVDI RKDLYANSVL 310 320 330 340 350 360 SGGTTMYPGI ADRMQKEITA LAPSTIKIKI IAPPERKYSV WIGGSILASL STFQQMWISK 370 QEYDESGPGI VHRKCF

References

[1]	"Sequence analysis of the indirect flight muscle actin-encoding gene of Drosophila simulans." Beifuss M.J., Durica D.S. Gene 118:163-170(1992) [PubMed: 1511890] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M87274 Genomic DNA. No translation available.
PIR	JC1246.
RefSeq	XP_002103310.1.
3D structure databases
HSSP	HSSP built from PDB template 1HLU based on UniProtKB P02570.
SMR	P83968. Positions 8-372.
ModBase	Search...
Genome annotation databases
GeneID	6727955.
Organism-specific databases
FlyBase	FBgn0012823. Dsim\Act88F.
Family and domain databases
InterPro	IPR004001. Actin_CS. IPR004000. Actin_like. [Graphical view]
PANTHER	PTHR11937. Actin_like. 1 hit.
Pfam	PF00022. Actin. 1 hit. [Graphical view]
PRINTS	PR00190. ACTIN.
SMART	SM00268. ACTIN. 1 hit. [Graphical view]
PROSITE	PS00406. ACTINS_1. 1 hit. PS00432. ACTINS_2. 1 hit. PS01132. ACTINS_ACT_LIKE. 1 hit. [Graphical view]
ProDom	P83968. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ACT6_DROSI

Accession

Primary (citable) accession number: P83968
Secondary accession number(s): P02575, P45893, Q9VF62

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	June 7, 2004
Last modified:	September 23, 2008
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project