Reviewed, UniProtKB/Swiss-Prot Q23919 (PGM1_DICDI)

Names and origin

Protein names

Recommended name:
    Phosphoglucomutase-1
      Short name(s)=PGM 1
    EC=5.4.2.2
Alternative name(s):
    Glucose phosphomutase 1

Gene names

Name:	pgmA
ORF Names:	DDB_0191348

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	572 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	This enzyme participates in both the breakdown and synthesis of glucose By similarity.
Catalytic activity	Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	phosphoglucomutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 572	572	Phosphoglucomutase-1
Sites
	Active site	120	1	Phosphoserine intermediate By similarity
	Metal binding	120	1	Magnesium (via phosphate group) By similarity
	Metal binding	288	1	Magnesium By similarity
	Metal binding	290	1	Magnesium By similarity
	Metal binding	292	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q23919-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: ED7E8F58F16F563A	FASTA	572	63,230
	10 20 30 40 50 60 MFKQTFKVNI IPTQPFEGQK PGTSGLRKKV TEVMKTNYLG NFVQSIFNAL PEDKLKGSTI 70 80 90 100 110 120 VVGGDGRYYN NDAIQLIFQI AAANGVGKIL VGRYGLLSTP AISAIVRARS ALGAIILTAS 130 140 150 160 170 180 HNPGGPNGDF GIKYNMSNGG PAPESITNAI YKHTTSITQI KTTRNVSVDN LGLLKTYEWN 190 200 210 220 230 240 DGEFVIEVID SADDYVSLLK TIFDFDGIRK FVKNHPNFTF NFDAMSGVTG AYGKRIFTDE 250 260 270 280 290 300 LGIPESCLIN CNPSQDFNGG HPDPNLTYAP LLVKKMNNGE FDMGCASDGD GDRNMILGKR 310 320 330 340 350 360 FFLNPSDSVA VIASNYKAIP YFNKGGLKGL ARSMPTSAAL ERVATDLKVP FFEVPTGWKF 370 380 390 400 410 420 FGNLMDAGTL SICGEESFGT GSDHIREKDG IWAIICWLQI LTHHNQSTND KNFVSIEEIV 430 440 450 460 470 480 KQHWAKYGRN YYSRYDYEEI DTAPAEAMMK HVSQQIESKQ LIGKKFTGIS DSLEYEIASC 490 500 510 520 530 540 DDFEYKDPID SSVSSHQGLR IIFTDGSRII YRLSGTGSTG ATVRVYFDKY ETQPTQLNND 550 560 570 VQTHLKSLIH IALVEISKLN HYTGRNEPNV IT

References

[1]

"Ordered yeast artificial chromosome clones representing the Dictyostelium discoideum genome." Kuspa A., Loomis W.F. Proc. Natl. Acad. Sci. U.S.A. 93:5562-5566(1996) [PubMed: 8643615] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: AX4.

[2]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U61984 mRNA. Translation: AAB03667.1. AAFI02000112 Genomic DNA. Translation: EAL63190.1.
RefSeq	XP_636703.1.
3D structure databases
HSSP	HSSP built from PDB template 3PMG based on UniProtKB P00949.
ModBase	Search...
Genome annotation databases
GeneID	3388267.
KEGG	ddi:DDB_0191348.
Organism-specific databases
dictyBase	DDB0191348. pgmA.
Family and domain databases
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. A-D-PHexomutase_N. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProDom	Q23919. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

PGM1_DICDI

Accession

Primary (citable) accession number: Q23919
Secondary accession number(s): Q54IV0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	November 1, 1996
Last modified:	July 22, 2008
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)