Reviewed, UniProtKB/Swiss-Prot Q03148 (SNZ1_YEAST)

Names and origin

Protein names

Recommended name:
    Pyridoxine biosynthesis protein SNZ1
Alternative name(s):
    PDX1 homolog 1
    p35

Gene names

Name:	SNZ1
Ordered Locus Names:	YMR096W
ORF Names:	YM6543.03

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Required for the production of pyridoxine (vitamin B6). May be involved in growth arrest and cellular response to nutrient limitation. Required for growth in the presence of low level of intracellular pyridoxine.
Subunit structure	Interacts with YHR198C/FMP22.
Developmental stage	Shows increased synthesis after entry into stationary phase.
Miscellaneous	Defects in SNZ1 cause some sensibility to 6-azauracil, an inhibitor of purine and pyrimidine biosynthetic enzymes, and methylene blue, a producer of singlet oxygen. These effects are probably due to the inability to synthesize pyridoxine.
Sequence similarities	Belongs to the pdxS/SNZ family.

Ontologies

Keywords
Biological process	Pyridoxine biosynthesis
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyridoxine metabolic process Ref.3 Inferred from direct assay. Source: SGD
Molecular function	protein binding Ref.3 Ref.5 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SNO1	Q03144	1	EBI-17618,EBI-28190
SNZ2	P53824	1	EBI-17618,EBI-17623
SNZ3	P43545	1	EBI-17618,EBI-17629

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 297	297	Pyridoxine biosynthesis protein SNZ1		PRO_0000109358

Sequences

	Sequence		Length	Mass (Da)
	Q03148-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: C5BC77711B415D9F	FASTA	297	31,817
	10 20 30 40 50 60 MTGEDFKIKS GLAQMLKGGV IMDVVTPEQA KIAEKSGACA VMALESIPAD MRKSGKVCRM 70 80 90 100 110 120 SDPKMIKDIM NSVSIPVMAK VRIGHFVEAQ IIEALEVDYI DESEVLTPAD WTHHIEKDKF 130 140 150 160 170 180 KVPFVCGAKD LGEALRRINE GAAMIRTKGE AGTGDVSEAV KHIRRITEEI KACQQLKSED 190 200 210 220 230 240 DIAKVAEEMR VPVSLLKDVL EKGKLPVVNF AAGGVATPAD AALLMQLGCD GVFVGSGIFK 250 260 270 280 290 SSNPVRLATA VVEATTHFDN PSKLLEVSSD LGELMGGVSI ESISHASNGV RLSEIGW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. , Skelton J., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:90-93(1997) [PubMed: 9169872] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"A stationary-phase gene in Saccharomyces cerevisiae is a member of a novel, highly conserved gene family." Braun E.L., Fuge E.K., Padilla P.A., Werner-Washburne M. J. Bacteriol. 178:6865-6872(1996) [PubMed: 8955308] [Abstract] Cited for: IDENTIFICATION.
[3]	"The highly conserved, coregulated SNO and SNZ gene families in Saccharomyces cerevisiae respond to nutrient limitation." Padilla P.A., Fuge E.K., Crawford M.E., Errett A., Werner-Washburne M. J. Bacteriol. 180:5718-5726(1998) [PubMed: 9791124] [Abstract] Cited for: INDUCTION.
[4]	Erratum Padilla P.A., Fuge E.K., Crawford M.E., Errett A., Werner-Washburne M. J. Bacteriol. 180:6794-6794(1998)
[5]	"Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6." Rodriguez-Navarro S., Llorente B., Rodriguez-Manzaneque M.T., Ramne A., Uber G., Marchesan D., Dujon B., Herrero E., Sunnerhagen P., Perez-Ortin J.E. Yeast 19:1261-1276(2002) [PubMed: 12271461] [Abstract] Cited for: FUNCTION, INTERACTION WITH FMP22.
[6]	"Tpn1p, the plasma membrane vitamin B6 transporter of Saccharomyces cerevisiae." Stolz J., Vielreicher M. J. Biol. Chem. 278:18990-18996(2003) [PubMed: 12649274] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z49807 Genomic DNA. Translation: CAA89897.1.
PIR	S55082.
RefSeq	NP_013814.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:1643N.
IntAct	Q03148.
Proteomic databases
PeptideAtlas	Q03148.
Genome annotation databases
Ensembl	YMR096W. Saccharomyces cerevisiae. [Contig view]
GeneID	855121.
GenomeReviews	Gene locus YMR096W in contig Z71257_GR.
KEGG	sce:YMR096W.
NMPDR	fig|4932.3.peg.4861.
Organism-specific databases
CYGD	YMR096w.
SGD	S000004702. SNZ1.
Yeast-GFP	Search...
Phylogenomic databases
HOGENOM	Q03148.
Gene expression databases
GermOnline	YMR096W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR001852. Snz1p/Sor1. [Graphical view]
Pfam	PF01680. SOR_SNZ. 1 hit. [Graphical view]
PIRSF	PIRSF029271. Pdx1. 1 hit.
ProDom	PD004958. Snz1p/Sor1. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00343. Snz1p/Sor1. 1 hit.
PROSITE	PS01235. PDXS_SNZ_1. 1 hit. PS51129. PDXS_SNZ_2. 1 hit. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...
Other Resources
LinkHub	Q03148.
NextBio	978476.

Entry information

Entry name

SNZ1_YEAST

Accession

Primary (citable) accession number: Q03148

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 4, 2008
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)