Reviewed, UniProtKB/Swiss-Prot Q07911 (FLAB_HELPY)

Names and origin

Protein names

Recommended name:
    Flagellin B
Alternative name(s):
    Flagellin N

Gene names

Name:	flaB
Ordered Locus Names:	HP_0115

Organism

Helicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]

Taxonomic identifier

210 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	514 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. Important for motility and virulence.
Subunit structure	Heteropolymer of flaA and flaB. FlaB is located proximal to the hook while the remainder of the filament is composed of the predominant flaA.
Subcellular location	Secreted. Bacterial flagellum.
Sequence similarities	Belongs to the bacterial flagellin family.

Ontologies

Keywords
Biological process	Virulence
Cellular component	Bacterial flagellum Secreted
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 514	513	Flagellin B
Natural variations
	Natural variant	155	1	A → T in strain: 85P.
	Natural variant	182	1	A → E in strain: 85P.
	Natural variant	190 – 191	2	AQ → GA in strain: 85P.
	Natural variant	335	1	A → T in strain: 85P.

Sequences

	Sequence		Length	Mass (Da)
	Q07911-1 [UniParc]. Last modified January 23, 2007. Version 4. Checksum: 1E3D0728BD14A584	FASTA	514	53,882
	10 20 30 40 50 60 MSFRINTNIA ALTSHAVGVQ NNRDLSSSLE KLSSGLRINK AADDSSGMAI ADSLRSQSAN 70 80 90 100 110 120 LGQAIRNAND AIGMVQTADK AMDEQIKILD TIKTKAVQAA QDGQTLESRR ALQSDIQRLL 130 140 150 160 170 180 EELDNIANTT SFNGQQMLSG SFSNKEFQIG AYSNATVKAS IGSTSSDKIG HVRMETSSFS 190 200 210 220 230 240 GAGMLASAAA QNLTEVGLNF KQVNGVNDYK IETVRISTSA GTGIGALSEI INRFSNTLGV 250 260 270 280 290 300 RASYNVMATG GTPVQSGTVR ELTINGVEIG TVNDVHKNDA DGRLTNAINS VKDRTGVEAS 310 320 330 340 350 360 LDIQGRINLH SIDGRAISVH AASASGQVFG GGNFAGISGT QHAVIGRLTL TRTDARDIIV 370 380 390 400 410 420 SGVNFSHVGF HSAQGVAEYT VNLRAVRGIF DANVASAAGA NANGAQAETN SQGIGAGVTS 430 440 450 460 470 480 LKGAMIVMDM ADSARTQLDK IRSDMGSVQM ELVTTINNIS VTQVNVKAAE SQIRDVDFAE 490 500 510 ESANFSKYNI LAQSGSFAMA QANAVQQNVL RLLQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and genetic characterization of the Helicobacter pylori and Helicobacter mustelae flaB flagellin genes and construction of H. pylori flaA- and flaB-negative mutants by electroporation-mediated allelic exchange." Suerbaum S., Josenhans C., Labigne A. J. Bacteriol. 175:3278-3288(1993) [PubMed: 8501031] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 85P.
[2]	"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.
[3]	"Identification, characterization, and spatial localization of two flagellin species in Helicobacter pylori flagella." Kostrzynska M., Betts J.D., Austin J.W., Trust T.J. J. Bacteriol. 173:937-946(1991) [PubMed: 1704004] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-21. Strain: NTCC 11637 / Isolate 915.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L08907 Genomic DNA. Translation: AAA25016.1. AE000511 Genomic DNA. Translation: AAD07183.1.
PIR	C64534.
RefSeq	NP_206915.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:3194N.
Genome annotation databases
GeneID	900158.
GenomeReviews	Gene locus HP_0115 in contig AE000511_GR.
KEGG	hpy:HP0115.
NMPDR	fig|85962.1.peg.113.
TIGR	HP_0115.
Phylogenomic databases
HOGENOM	Q07911.
Family and domain databases
InterPro	IPR001029. Flagellin_C. IPR010810. Flagellin_IN. IPR001492. Flagellin_N. [Graphical view]
Pfam	PF00700. Flagellin_C. 1 hit. PF07196. Flagellin_IN. 2 hits. PF00669. Flagellin_N. 1 hit. [Graphical view]
PRINTS	PR00207. FLAGELLIN.
ProDom	PD000316. Flagellin_C. 1 hit. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

FLAB_HELPY

Accession

Primary (citable) accession number: Q07911

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	January 23, 2007
Last modified:	July 22, 2008
This is version 60 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)