Reviewed, UniProtKB/Swiss-Prot Q08AU7 (MYADL_MOUSE)

Names and origin

Protein names

Recommended name:
    Myeloid-associated differentiation marker-like protein

Gene names

Name:

Myadml

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane proteinPotential.
Sequence similarities	Belongs to the MAL family. Contains 2 MARVEL domains.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Transmembrane
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q08AU7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q08AU7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     121-149: RNFRLAASVFAGLLFLAYAAEVALTRARP → APCQRPAPESPWKDDDVMTAMEYLSRHPT
     150-303: Missing.

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 303	303	Myeloid-associated differentiation marker-like protein
Regions
	Transmembrane	49 – 69	21	Potential
	Transmembrane	86 – 106	21	Potential
	Transmembrane	125 – 145	21	Potential
	Transmembrane	159 – 179	21	Potential
	Transmembrane	194 – 214	21	Potential
	Transmembrane	228 – 248	21	Potential
	Transmembrane	274 – 294	21	Potential
	Domain	13 – 150	138	MARVEL 1
	Domain	155 – 299	145	MARVEL 2
Natural variations
	Alternative sequence	121 – 149	29	RNFRL…TRARP → APCQRPAPESPWKDDDVMTA MEYLSRHPT in isoform 2.
	Alternative sequence	150 – 303	154	Missing in isoform 2.
Experimental info
	Sequence conflict	22	1	R → Q in AAH91000. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 31, 2006. Version 1. Checksum: B0B9CBBE605BE26C	FASTA	303	32,789
	10 20 30 40 50 60 MEPPGGAYLH LGAVTSPVGT ARMLQLAFGC TTFSLVAHRG GFGGVQGTFC MAAWGFCFAF 70 80 90 100 110 120 SVLVVACEFT KLHSCLRLSW GNFTAAFAML ATLLCATAAV IYPLYFTRLE CPPEPAGCMV 130 140 150 160 170 180 RNFRLAASVF AGLLFLAYAA EVALTRARPG QVASYMATVS GLLKIVQAFV ACIIFGALVH 190 200 210 220 230 240 ESRYGRYVAT QWCVAVYSLC FMATVAVVVL SVMGHTAGLG CPFDRLVIVY TFLAVLLYLS 250 260 270 280 290 300 AAVIWPVFCF DPKYGEPGRP ADCLRGSCPW DSQLVVAIFT YVNLLLYIVD LAYSQRIRFV PTL
	Isoform 2 [UniParc]. Checksum: F398ECD99E71745D		149	16,009
	10 20 30 40 50 60 MEPPGGAYLH LGAVTSPVGT ARMLQLAFGC TTFSLVAHRG GFGGVQGTFC MAAWGFCFAF 70 80 90 100 110 120 SVLVVACEFT KLHSCLRLSW GNFTAAFAML ATLLCATAAV IYPLYFTRLE CPPEPAGCMV 130 140 APCQRPAPES PWKDDDVMTA MEYLSRHPT

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: C57BL/6J.
[2]	The mouse genome sequencing consortium Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Heart.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK003645 mRNA. Translation: BAB22911.1. Different initiation. AL663030 Genomic DNA. Translation: CAM27102.1. Different initiation. BC091000 mRNA. Translation: AAH91000.1. BC109329 mRNA. Translation: AAI09330.1. BC125008 mRNA. Translation: AAI25009.1.
RefSeq	XP_126634.3. XP_922439.1.
UniGene	Mm.194594
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	68515.
KEGG	mmu:68515.
Organism-specific databases
MGI	MGI:1915765. 1110012N22Rik.
Phylogenomic databases
HOVERGEN	Q08AU7.
Family and domain databases
InterPro	IPR008253. Marvel. [Graphical view]
Pfam	PF01284. MARVEL. 2 hits. [Graphical view]
PROSITE	PS51225. MARVEL. 2 hits. [Graphical view]
ProDom	Q08AU7. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

MYADL_MOUSE

Accession

Primary (citable) accession number: Q08AU7
Secondary accession number(s): Q5BKP1, Q9D1F1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	October 31, 2006
Last modified:	July 22, 2008
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)