Reviewed, UniProtKB/Swiss-Prot Q09712 (GPI18_SCHPO)

Names and origin

Protein names

Recommended name:
    GPI mannosyltransferase 2
    EC=2.4.1.-
Alternative name(s):
    GPI mannosyltransferase II
      Short name=GPI-MT-II
    Glycosylphosphatidylinositol-anchor biosynthesis protein 18

Gene names

Name:	gpi18
ORF Names:	SPAC18B11.05

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	426 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly By similarity.
Pathway	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane proteinBy similarity.
Sequence similarities	Belongs to the PIGV family.

Ontologies

Keywords
Biological process	GPI-anchor biosynthesis
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	GPI anchor biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: InterPro integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	mannosyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 426	426	GPI mannosyltransferase 2		PRO_0000116387
Regions
	Transmembrane	33 – 53	21	Potential
	Transmembrane	129 – 149	21	Potential
	Transmembrane	167 – 189	23	Potential
	Transmembrane	223 – 243	21	Potential
	Transmembrane	252 – 271	20	Potential
	Transmembrane	319 – 339	21	Potential
	Transmembrane	351 – 371	21	Potential
	Transmembrane	403 – 423	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q09712-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: CAACF57FFAD4E0FC	FASTA	426	48,825
	10 20 30 40 50 60 MKLNESAMKN AEKKSNSYLA IRMTRSGYNY FKGICVCTFL LSTILYLGIA VIMSHLCVFD 70 80 90 100 110 120 DTAMLYLRQN RSRLAESNIF RTLFISWIRW DAIYFVDMAV NGSLFEQEWA FSSLWPKIIS 130 140 150 160 170 180 FLAFRSKDVV LLGIVSCFAS IFFHAIACYA LYLLTKSIFS NQKMTAYTVI FYCFSPSGIY 190 200 210 220 230 240 MSVGYTESLF AAFSFLGLLL FIKKQQYPAA FLWSLATLIR SNGIFWCIFF GMPAIGTLKI 250 260 270 280 290 300 SLERLQLTFM QVSQLVGYGT KCLIILVPFF YNQYLGFKLF CPGVAWCNKS LPLIYPAVQE 310 320 330 340 350 360 KYWNVGFLRY WTLNNIPNFL FALLSIIPIL FALFYSISGS TLHSFRSIKS HLVLSALYLY 370 380 390 400 410 420 IGCFHMHTQV LNRMSSALPL LYWSMAHATL YAKSRNLKAF GHCILFVWIV YTVIQAGLYG SFLPPA

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU329670 Genomic DNA. Translation: CAA90590.1.
PIR	S58304. T37909.
RefSeq	NP_592878.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2542588.
KEGG	spo:SPAC18B11.05.
NMPDR	fig|4896.1.peg.2848.
Organism-specific databases
GeneDB_Spombe	SPAC18B11.05.
Enzyme and pathway databases
BioCyc	SPOM-XXX-01:SPOM-XXX-01-000612-MON.
Gene expression databases
ArrayExpress	Q09712.
Family and domain databases
InterPro	IPR007315. Mannosyl_trans2. [Graphical view]
PANTHER	PTHR12468. Mannosyl_trans2. 1 hit.
Pfam	PF04188. Mannosyl_trans2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPI18_SCHPO

Accession

Primary (citable) accession number: Q09712

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 25, 2008
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)