Reviewed, UniProtKB/Swiss-Prot Q09831 (PPK14_SCHPO)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase ppk14
    EC=2.7.11.1

Gene names

Name:	ppk14
ORF Names:	SPAC4G8.05

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	566 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. KIN82 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Ref.2 Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 566	566	Serine/threonine-protein kinase ppk14		PRO_0000086043
Regions
	Domain	195 – 485	291	Protein kinase
	Nucleotide binding	201 – 209	9	ATP By similarity
Sites
	Active site	320	1	Proton acceptor By similarity
	Binding site	224	1	ATP By similarity
Amino acid modifications
	Modified residue	379	1	Phosphothreonine
	Modified residue	381	1	Phosphoserine
	Modified residue	385	1	Phosphothreonine

Sequences

	Sequence		Length	Mass (Da)
	Q09831-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 3D18B4F84E10AA13	FASTA	566	63,482
	10 20 30 40 50 60 MNELHDGESS EEGRINVEDH LEEAKKDDTG HWKHSGTAKP SKFRAFIRLH FKDSRKFAFS 70 80 90 100 110 120 RKKEKELTSE DSDAANQSPS GAPESQTEEE SDRKIDGTGS SAEGGDGSGT DSISVIKKSF 130 140 150 160 170 180 FKSGRKKKDV PKSRNVSRSN GADTSVQREK LKDIFSPHGK EKELAHIKKT VATRARTYSS 190 200 210 220 230 240 NSIKICDVEV GPSSFEKVFL LGKGDVGRVY LVREKKSGKF YAMKVLSKQE MIKRNKSKRA 250 260 270 280 290 300 FAEQHILATS NHPFIVTLYH SFQSDEYLYL CMEYCMGGEF FRALQRRPGR CLSENEAKFY 310 320 330 340 350 360 IAEVTAALEY LHLMGFIYRD LKPENILLHE SGHIMLSDFD LSKQSNSAGA PTVIQARNAP 370 380 390 400 410 420 SAQNAYALDT KSCIADFRTN SFVGTEEYIA PEVIKGCGHT SAVDWWTLGI LFYEMLYATT 430 440 450 460 470 480 PFKGKNRNMT FSNILHKDVI FPEYADAPSI SSLCKNLIRK LLVKDENDRL GSQAGAADVK 490 500 510 520 530 540 LHPFFKNVQW ALLRHTEPPI IPKLAPIDEK GNPNISHLKE SKSLDITHSP QNTQTVEVPL 550 560 SNLSGADHGD DPFESFNSVT VHHEWD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.
[2]	"Systematic deletion analysis of fission yeast protein kinases." Bimbo A., Jia Y., Poh S.L., Karuturi R.K.M., den Elzen N., Peng X., Zheng L., O'Connell M., Liu E.T., Balasubramanian M.K., Liu J. Eukaryot. Cell 4:799-813(2005) [PubMed: 15821139] [Abstract] Cited for: IDENTIFICATION.
[3]	"Phosphoproteome analysis of fission yeast." Wilson-Grady J.T., Villen J., Gygi S.P. J. Proteome Res. 7:1088-1097(2008) [PubMed: 18257517] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-379; SER-381 AND THR-385, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU329670 Genomic DNA. Translation: CAA91206.1.
PIR	S62482.
RefSeq	NP_593065.1.
3D structure databases
HSSP	HSSP built from PDB template 1GZK based on UniProtKB P31751.
ModBase	Search...
Genome annotation databases
GeneID	2543432.
KEGG	spo:SPAC4G8.05.
NMPDR	fig|4896.1.peg.3035.
Organism-specific databases
GeneDB_Spombe	SPAC4G8.05.
Enzyme and pathway databases
BioCyc	SPOM-XXX-01:SPOM-XXX-01-000780-MON.
Gene expression databases
ArrayExpress	Q09831.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPK14_SCHPO

Accession

Primary (citable) accession number: Q09831

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	November 25, 2008
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)