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Reviewed, UniProtKB/Swiss-Prot Q0VC81 (AA3R_BOVIN)

Last modified September 2, 2008. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Adenosine A3 receptor
Gene names
Name: ADORA3
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

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Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction By similarity.

Subcellular location

Cell membrane; Multi-pass membrane proteinBy similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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Ontologies

Keywords

   Cellular componentCell membrane
Membrane
   DomainTransmembrane
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
Lipoprotein
Palmitate
Phosphoprotein

Gene Ontology (GO)

None. [Check GOA]

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 317317Adenosine A3 receptor

Regions

Topological domain1 – 1414Extracellular Potential
Transmembrane15 – 37231 Potential
Topological domain38 – 4811Cytoplasmic Potential
Transmembrane49 – 72242 Potential
Topological domain73 – 8412Extracellular Potential
Transmembrane85 – 106223 Potential
Topological domain107 – 12620Cytoplasmic Potential
Transmembrane127 – 148224 Potential
Topological domain149 – 17628Extracellular Potential
Transmembrane177 – 197215 Potential
Topological domain198 – 23033Cytoplasmic Potential
Transmembrane231 – 254246 Potential
Topological domain255 – 2606Extracellular Potential
Transmembrane261 – 283237 Potential
Topological domain284 – 31734Cytoplasmic Potential

Amino acid modifications

Modified residue3161Phosphoserine By similarity
Lipidation3021S-palmitoyl cysteine Potential
Glycosylation41N-linked (GlcNAc...) Potential
Disulfide bond83 ↔ 165 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q0VC81-1 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 4843F7A27DDF0907

FASTA31735,911
        10         20         30         40         50         60 
MPVNSTAVSL ASVTYISVEI LIGLCAIVGN VLVIWVVKLN PSLQTTTFYF IVSLALADIA 

        70         80         90        100        110        120 
VGVLVMPLAI VISLGVTIHF YSCLLMTCLL MIFTHASIMS LLAIAVDRYL RVKLTVRYRR 

       130        140        150        160        170        180 
VTTQRRIWLA LGLCWLVSFL VGLTPMFGWN MKLSSADKNL TFLPCQFRSV MRMDYMVYFS 

       190        200        210        220        230        240 
FFTWILIPLV VMCAIYFDIF YVIRNRLSQN FSGSKETGAF YGREFKTAKS LSLVLFLFAL 

       250        260        270        280        290        300 
SWLPLSIINC IIYFNGEVPQ IVLYLGILLS HANSMMNPIV YAYKIKKFKE TYLLILKACV 

       310 
ICQPSKSMDP SIEQTSE

« Hide

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References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Hippocampus.

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Cross-references

Sequence databases

BC120305 mRNA. Translation: AAI20306.1.
RefSeqNP_001098081.1.
UniGeneBt.40521

3D structure databases

ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Genome annotation databases

EnsemblENSBTAG00000007642. Bos taurus. [Contig view]
GeneID780806.

Phylogenomic databases

HOVERGENQ0VC81.

Family and domain databases

InterProIPR000466. Adeno_A3_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00555. ADENOSINEA3R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProDomQ0VC81.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameAA3R_BOVIN
AccessionPrimary (citable) accession number: Q0VC81
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: September 5, 2006
Last modified: September 2, 2008
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents