true
2000-05-30
2008-07-22
108
TRAF2_HUMAN
TRA2_HUMAN
TNF receptor-associated factor 2
Tumor necrosis factor type 2 receptor-associated protein 3
Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor.
Song H.Y.
Donner D.B.
1995
Biochem. J.
309
825-829
NUCLEOTIDE SEQUENCE [MRNA]
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T.
Suzuki Y.
Nishikawa T.
Otsuki T.
Sugiyama T.
Irie R.
Wakamatsu A.
Hayashi K.
Sato H.
Nagai K.
Kimura K.
Makita H.
Sekine M.
Obayashi M.
Nishi T.
Shibahara T.
Tanaka T.
Ishii S.
Yamamoto J.
Saito K.
Kawai Y.
Isono Y.
Nakamura Y.
Nagahari K.
Murakami K.
Yasuda T.
Iwayanagi T.
Wagatsuma M.
Shiratori A.
Sudo H.
Hosoiri T.
Kaku Y.
Kodaira H.
Kondo H.
Sugawara M.
Takahashi M.
Kanda K.
Yokoi T.
Furuya T.
Kikkawa E.
Omura Y.
Abe K.
Kamihara K.
Katsuta N.
Sato K.
Tanikawa M.
Yamazaki M.
Ninomiya K.
Ishibashi T.
Yamashita H.
Murakawa K.
Fujimori K.
Tanai H.
Kimata M.
Watanabe M.
Hiraoka S.
Chiba Y.
Ishida S.
Ono Y.
Takiguchi S.
Watanabe S.
Yosida M.
Hotuta T.
Kusano J.
Kanehori K.
Takahashi-Fujii A.
Hara H.
Tanase T.-O.
Nomura Y.
Togiya S.
Komai F.
Hara R.
Takeuchi K.
Arita M.
Imose N.
Musashino K.
Yuuki H.
Oshima A.
Sasaki N.
Aotsuka S.
Yoshikawa Y.
Matsunawa H.
Ichihara T.
Shiohata N.
Sano S.
Moriya S.
Momiyama H.
Satoh N.
Takami S.
Terashima Y.
Suzuki O.
Nakagawa S.
Senoh A.
Mizoguchi H.
Goto Y.
Shimizu F.
Wakebe H.
Hishigaki H.
Watanabe T.
Sugiyama A.
Takemoto M.
Kawakami B.
Yamazaki M.'
Watanabe K.
Kumagai A.
Itakura S.
Fukuzumi Y.
Fujimori Y.
Komiyama M.
Tashiro H.
Tanigami A.
Fujiwara T.
Ono T.
Yamada K.
Fujii Y.
Ozaki K.
Hirao M.
Ohmori Y.
Kawabata A.
Hikiji T.
Kobatake N.
Inagaki H.
Ikema Y.
Okamoto S.
Okitani R.
Kawakami T.
Noguchi S.
Itoh T.
Shigeta K.
Senba T.
Matsumura K.
Nakajima Y.
Mizuno T.
Morinaga M.
Sasaki M.
Togashi T.
Oyama M.
Hata H.
Watanabe M.'
Komatsu T.
Mizushima-Sugano J.
Satoh T.
Shirai Y.
Takahashi Y.
Nakagawa K.
Okumura K.
Nagase T.
Nomura N.
Kikuchi H.
Masuho Y.
Yamashita R.
Nakai K.
Yada T.
Nakamura Y.'
Ohara O.
Isogai T.
Sugano S.
doi:10.1038/ng1285
2004
Nat. Genet.
36
40-45
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
Cerebellum
SeattleSNPs program for genomic applications
2004-05
EMBL/GenBank/DDBJ
NUCLEOTIDE SEQUENCE [GENOMIC DNA]
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team
doi:10.1101/gr.2596504
2004
Genome Res.
14
2121-2127
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
Colon
Fetal brain
Kidney
Leukocyte
Stomach
Uterus
A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.
Rothe M.
Wong S.C.
Henzel W.J.
Goeddel D.V.
doi:10.1016/0092-8674(94)90532-0
1994
Cell
78
681-692
NUCLEOTIDE SEQUENCE [MRNA] OF 201-501
INTERACTION WITH TRAF1 AND TNFRSF1B
NF-kB activation by a signaling complex containing TRAF2, TANK, and TBK1, a novel IKK-related kinase.
Pomerantz J.L.
Baltimore D.
doi:10.1093/emboj/18.23.6694
1999
EMBO J.
18
6694-6704
INTERACTION WITH TBK1
Spleen
The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators.
Wajant H.
Henkler F.
Scheurich P.
doi:10.1016/S0898-6568(01)00160-7
2001
Cell. Signal.
13
389-400
REVIEW
Tumor necrosis factor receptor-associated factors (TRAFs).
Bradley J.R.
Pober J.S.
doi:10.1038/sj.onc.1204788
2001
Oncogene
20
6482-6491
REVIEW
T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors.
Lee S.Y.
Park C.G.
Choi Y.
doi:10.1084/jem.183.2.669
1996
J. Exp. Med.
183
669-674
INTERACTION WITH TNFRSF8
I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.
Rothe M.
Xiong J.
Shu H.-B.
Williamson K.
Goddard A.
Goeddel D.V.
doi:10.1073/pnas.93.16.8241
1996
Proc. Natl. Acad. Sci. U.S.A.
93
8241-8246
INTERACTION WITH TANK
ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5.
Hsu H.
Solovyev I.
Colombero A.
Elliott R.
Kelley M.
Boyle W.J.
doi:10.1074/jbc.272.21.13471
1997
J. Biol. Chem.
272
13471-13474
INTERACTION WITH TNFRSF14
TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation.
Lee S.Y.
Lee S.Y.'
Choi Y.
doi:10.1084/jem.185.7.1275
1997
J. Exp. Med.
185
1275-1285
INTERACTION WITH TRIP
MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1.
Malinin N.L.
Boldin M.P.
Kovalenko A.V.
Wallach D.
doi:10.1038/385540a0
1997
Nature
385
540-544
INTERACTION WITH MAP3K14
CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization.
Pullen S.S.
Miller H.G.
Everdeen D.S.
Dang T.T.
Crute J.J.
Kehry M.R.
doi:10.1021/bi981067q
1998
Biochemistry
37
11836-11845
INTERACTION WITH TNFRSF5
Identification of CARDIAK, a RIP-like kinase that associates with caspase-1.
Thome M.
Hofmann K.
Burns K.
Martinon F.
Bodmer J.-L.
Mattmann C.
Tschopp J.
doi:10.1016/S0960-9822(07)00352-1
1998
Curr. Biol.
8
885-888
INTERACTION WITH RIPK2
The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2.
Gravestein L.A.
Amsen D.
Boes M.
Calvo C.R.
Kruisbeek A.M.
Borst J.
doi:10.1002/(SICI)1521-4141(199807)28:07<2208::AID-IMMU2208>3.0.CO;2-L
1998
Eur. J. Immunol.
28
2208-2216
INTERACTION WITH CD27
4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB.
Arch R.H.
Thompson C.B.
1998
Mol. Cell. Biol.
18
558-565
INTERACTION WITH TNFRSF4 AND TNFRSF9
Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation.
Kawamata S.
Hori T.
Imura A.
Takaori-Kondo A.
Uchiyama T.
doi:10.1074/jbc.273.10.5808
1998
J. Biol. Chem.
273
5808-5814
INTERACTION WITH TNFRSF4
The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor.
Wong B.R.
Josien R.
Lee S.Y.
Vologodskaia M.
Steinman R.M.
Choi Y.
doi:10.1074/jbc.273.43.28355
1998
J. Biol. Chem.
273
28355-28359
INTERACTION WITH TNFRSF11A
CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand.
Saoulli K.
Lee S.Y.
Cannons J.L.
Yeh W.C.
Santana A.
Goldstein M.D.
Bangia N.
DeBenedette M.A.
Mak T.W.
Choi Y.
Watts T.H.
doi:10.1084/jem.187.11.1849
1998
J. Exp. Med.
187
1849-1862
INTERACTION WITH TNFRSF9
ASK1 is essential for JNK/SAPK activation by TRAF2.
Nishitoh H.
Saitoh M.
Mochida Y.
Takeda K.
Nakano H.
Rothe M.
Miyazono K.
Ichijo H.
doi:10.1016/S1097-2765(00)80283-X
1998
Mol. Cell
2
389-395
INTERACTION WITH MAP3K5
Death deflected: IL-15 inhibits TNF-alpha-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15Ralpha chain.
Bulfone-Paus S.
Bulanova E.
Pohl T.
Budagian V.
Duerkop H.
Rueckert R.
Kunzendorf U.
Paus R.
Krause H.
1999
FASEB J.
13
1575-1585
INTERACTION WITH IL15RA
Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand.
Kwon B.
Yu K.-Y.
Ni J.
Yu G.-L.
Jang I.-K.
Kim Y.-J.
Xing L.
Liu D.
Wang S.-X.
Kwon B.S.
doi:10.1074/jbc.274.10.6056
1999
J. Biol. Chem.
274
6056-6061
INTERACTION WITH TNFRSF18
T-cell
TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction.
Ye X.
Mehlen P.
Rabizadeh S.
VanArsdale T.
Zhang H.
Shin H.
Wang J.J.L.
Leo E.
Zapata J.M.
Hauser C.A.
Reed J.C.
Bredesen D.E.
doi:10.1074/jbc.274.42.30202
1999
J. Biol. Chem.
274
30202-30208
INTERACTION WITH TNFRSF16
TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton.
Fu C.A.
Shen M.
Huang B.C.
Lasaga J.
Payan D.G.
Luo Y.
doi:10.1074/jbc.274.43.30729
1999
J. Biol. Chem.
274
30729-30737
INTERACTION WITH TNIK
Binding of CDK9 to TRAF2.
MacLachlan T.K.
Sang N.
De Luca A.
Puri P.L.
Levrero M.
Giordano A.
doi:10.1002/(SICI)1097-4644(19981215)71:4<467::AID-JCB2>3.3.CO;2-7
1998
J. Cell. Biochem.
71
467-478
INTERACTION WITH CDK9
TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death.
Eby M.T.
Jasmin A.
Kumar A.
Sharma K.
Chaudhary P.M.
doi:10.1074/jbc.275.20.15336
2000
J. Biol. Chem.
275
15336-15342
INTERACTION WITH TNFRSF19
TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation.
Xia X.-Z.
Treanor J.
Senaldi G.
Khare S.D.
Boone T.
Kelley M.
Theill L.E.
Colombero A.
Solovyev I.
Lee F.
McCabe S.
Elliott R.
Miner K.
Hawkins N.
Guo J.
Stolina M.
Yu G.
Wang J.
Delaney J.
Meng S.-Y.
Boyle W.J.
Hsu H.
doi:10.1084/jem.192.1.137
2000
J. Exp. Med.
192
137-143
INTERACTION WITH TNFRSF13B
Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2.
Chadee D.N.
Yuasa T.
Kyriakis J.M.
2002
Mol. Cell. Biol.
22
737-749
INTERACTION WITH MAP4K2
Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain.
Baud V.
Liu Z.-G.
Bennett B.
Suzuki N.
Xia Y.
Karin M.
1999
Genes Dev.
13
1297-1308
INTERACTION WITH MAP3K1
TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.
Pype S.
Declercq W.
Ibrahimi A.
Michiels C.
Van Rietschoten J.G.I.
Dewulf N.
de Boer M.
Vandenabeele P.
Huylebroeck D.
Remacle J.E.
doi:10.1074/jbc.M000531200
2000
J. Biol. Chem.
275
18586-18593
INTERACTION WITH TTRAP
Stress-induced decrease in TRAF2 stability is mediated by Siah2.
Habelhah H.
Frew I.J.
Laine A.
Janes P.W.
Relaix F.
Sassoon D.
Bowtell D.D.L.
Ronai Z.
doi:10.1093/emboj/cdf576
2002
EMBO J.
21
5756-5765
INTERACTION WITH SIAH2
DEGRADATION
The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination.
Kovalenko A.
Chable-Bessia C.
Cantarella G.
Israeel A.
Wallach D.
Courtois G.
doi:10.1038/nature01802
2003
Nature
424
801-805
INTERACTION WITH CYLD
AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.
Zhang H.
Zhang R.
Luo Y.
D'Alessio A.
Pober J.S.
Min W.
doi:10.1074/jbc.M407617200
2004
J. Biol. Chem.
279
44955-44965
INTERACTION WITH DAB2IP
VISA is an adapter protein required for virus-triggered IFN-beta Signaling.
Xu L.-G.
Wang Y.-Y.
Han K.-J.
Li L.-Y.
Zhai Z.
Shu H.-B.
doi:10.1016/j.molcel.2005.08.014
2005
Mol. Cell
19
727-740
INTERACTION WITH MAVS
Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB.
Tzimas C.
Michailidou G.
Arsenakis M.
Kieff E.
Mosialos G.
Hatzivassiliou E.G.
doi:10.1016/j.cellsig.2005.03.017
2006
Cell. Signal.
18
83-92
INTERACTION WITH USP48
Structural basis for self-association and receptor recognition of human TRAF2.
Park Y.C.
Burkitt V.
Villa A.R.
Tong L.
Wu H.
doi:10.1038/19110
1999
Nature
398
533-538
X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 310-501 IN COMPLEX WITH TNFRSF1B
Crystallographic analysis of CD40 recognition and signaling by human TRAF2.
McWhirter S.M.
Pullen S.S.
Holton J.M.
Crute J.J.
Kehry M.R.
Alber T.
doi:10.1073/pnas.96.15.8408
1999
Proc. Natl. Acad. Sci. U.S.A.
96
8408-8413
X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 334-501 IN COMPLEX WITH EBV BNFL1
X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 315-501 IN COMPLEX WITH TNFRSF5
X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 334-501 IN COMPLEX WITH TNFRSF4
X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 334-501 IN COMPLEX WITH TNFRSF9
A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction.
Park Y.C.
Ye H.
Hsia C.
Segal D.
Rich R.L.
Liou H.C.
Myszka D.G.
Wu H.
doi:10.1016/S0092-8674(00)80889-2
2000
Cell
101
777-787
X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 331-501 IN COMPLEX WITH TRADD
TRAF2
TRAP3
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Association to the receptor is also mediated by the interaction with TRADD. Mediates activation of NF-kappa-B and JNK and is involved in apoptosis. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. Seems to be involved in IL-15 signaling.
Homotrimer (Probable). Heteromer with TRAF1. Binds to TNFRSF1B/TNFR2, TNFRSF4 and TNFRSF5/CD40. Associates with CD27, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13B/TACI. TNFRSF14, TNFRSF16/NGFR, TNFRSF17/BCMA, TNFRSF18/AITR, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1, IL15RA, TANK/ITRAF, RIPK2, TNIK, MAP3K14, MAP3K5, MAP3K1, MAP4K2, CDK9, CSK, and TRAF-interacting protein TRAIP and TRAF and TNF receptor associated protein TTRAP. Interacts with TNFAIP3 and TRPC4AP. Interacts with PEG3 (By similarity). Binds to TRADD. Interacts with BIRC2 and BIRC3 N-terminus. Interacts with CYLD and TBK1. Interacts with MAVS/IPS1. Interacts with CASP8AP2 and USP48. Interacts with DAB2IP. Interacts wtih NFATC2IP and with HIVEP3 (By similarity).
The coiled coil domain mediates homo- and hetero-oligomerization.
The MATH/TRAF domain binds to receptor cytoplasmic domains.
Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation. Not ubiquitinated by SIAH1.
Contains 1 MATH domain.
Contains 1 RING-type zinc finger.
Contains 2 TRAF-type zinc fingers.
TNF receptor-associated factor 2
1
501
MATH
351
496
RING-type
34
73
TRAF-type 1
124
180
TRAF-type 2
177
233
299
348
In isoform 2.
EVKMPACGMVTEAPAVGSRPRSPSSYDLVLHVPLTGAEACLMSVEEETELLLR
122
122
205
310
RPFQAQCGHRYCSFCLASILRKL
343
365
315
318
335
347
350
360
361
369
381
384
389
395
400
402
403
405
406
414
419
421
430
434
443
447
454
456
460
463
467
474
475
480
482
484
489
496
No experimental confirmation available.
false
1
ATXN1
false
3
BIRC2
false
2
BIRC3
false
2
CD27
false
3
GSTP1
false
1
MAP3K1
false
1
MAP3K5
false
1
TNFRSF11A
false
4
TNFRSF14
false
1
TNFRSF19
false
2
TNFRSF1B
true
1
Tnfrsf4
true
1
Tnfrsf9
false
1
TRADD
SeattleSNPs
EMBL
EMBL
EMBL
EMBL
EMBL
EMBL
EMBL
PIR
RefSeq
UniGene
PDB
2.20
A/B/C/D/E/F=334-501
PDB
2.30
A/B/C/D/E/F=310-501
PDB
2.00
A/B/C=334-501
PDB
2.70
A/B/C=315-501
PDB
2.00
A/B/C/D/E/F/G/H=334-501
PDB
2.00
A/B/C/D/E/F=334-501
PDB
2.00
A/B/C/D/E/F=334-501
PDB
2.50
A/B/C/D/E/F=334-501
PDB
2.00
B=331-501
PDB
2.40
A/B/C=311-501
PDBsum
PDBsum
PDBsum
PDBsum
PDBsum
PDBsum
PDBsum
PDBsum
PDBsum
PDBsum
DIP
IntAct
PhosphoSite
Ensembl
Homo sapiens
GeneID
KEGG
H-InvDB
HGNC
TRAF2
HPA
HPA
HPA
MIM
gene
PharmGKB
HOVERGEN
Reactome
Apoptosis
ArrayExpress
CleanEx
GermOnline
Homo sapiens
InterPro
MATH
InterPro
TNF_recpt_TRAF
InterPro
TRAF-type
InterPro
Znf_RING
InterPro
Znf_RING/FYVE/PHD
InterPro
Znf_TRAF
Gene3D
TRAF-type
1
Gene3D
Znf_RING/FYVE/PHD
1
Pfam
MATH
1
Pfam
zf-C3HC4
1
Pfam
zf-TRAF
1
PIRSF
TRAF
1
SMART
MATH
1
SMART
RING
1
PROSITE
MATH
1
PROSITE
ZF_RING_1
1
PROSITE
ZF_RING_2
1
PROSITE
ZF_TRAF
2
Reactome
UniProtKB
ProtInc
UniProtKB
Reactome
UniProtKB
UniProtKB
UniProtKB
ProtInc
2002-09-19
2
55859
1
MAAASVTPPG SLELLQPGFS KTLLGTKLEA KYLCSACRNV LRRPFQAQCG HRYCSFCLAS ILSSGPQNCA ACVHEGIYEE GISILESSSA FPDNAARREV ESLPAVCPSD GCTWKGTLKE YESCHEGRCP LMLTECPACK GLVRLGEKER HLEHECPERS LSCRHCRAPC CGADVKAHHE VCPKFPLTCD GCGKKKIPRE KFQDHVKTCG KCRVPCRFHA IGCLETVEGE KQQEHEVQWL REHLAMLLSS VLEAKPLLGD QSHAGSELLQ RCESLEKKTA TFENIVCVLN REVERVAMTA EACSRQHRLD QDKIEALSSK VQQLERSIGL KDLAMADLEQ KVLEMEASTY DGVFIWKISD FARKRQEAVA GRIPAIFSPA FYTSRYGYKM CLRIYLNGDG TGRGTHLSLF FVVMKGPNDA LLRWPFNQKV TLMLLDQNNR EHVIDAFRPD VTSSSFQRPV NDMNIASGCP LFCPVSKMEA KNSYVRDDAI FIKAIVDLTG L
2