Reviewed, UniProtKB/Swiss-Prot Q12982 (BNIP2_HUMAN)

Names and origin

Protein names

Recommended name:
    BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

Gene names

Name:	BNIP2
Synonyms:	NIP2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins.
Subcellular location	Cytoplasm. Cytoplasm › perinuclear region. Note= Localizes to the nuclear envelope region and to other cytoplasmic structures.
Sequence similarities	Contains 1 CRAL-TRIO domain.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	anti-apoptosis Ref.1 Traceable author statement. Source: UniProtKB
Cellular component	cytoplasm Ref.1 Inferred from direct assay. Source: MGI nuclear envelope Ref.1 Inferred from direct assay. Source: UniProtKB
Molecular function	GTPase activator activity Traceable author statement. Source: ProtInc calcium ion binding Ref.1 Traceable author statement. Source: UniProtKB protein binding Ref.1 Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 314	314	BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
Regions
	Domain	147 – 304	158	CRAL-TRIO
Amino acid modifications
	Modified residue	114	1	Phosphoserine
	Modified residue	116	1	Phosphothreonine
Natural variations
	Natural variant	24	1	S → T: dbSNP rs6151509.

Sequences

	Sequence		Length	Mass (Da)
	Q12982-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 0A3CEC636569DD2F	FASTA	314	36,018
	10 20 30 40 50 60 MEGVELKEEW QDEDFPIPLP EDDSIEADIL AITGPEDQPG SLEVNGNKVR KKLMAPDISL 70 80 90 100 110 120 TLDPSDGSVL SDDLDESGEI DLDGLDTPSE NSNEFEWEDD LPKPKTTEVI RKGSITEYTA 130 140 150 160 170 180 AEEKEDGRRW RMFRIGEQDH RVDMKAIEPY KKVISHGGYY GDGLNAIVVF AVCFMPESSQ 190 200 210 220 230 240 PNYRYLMDNL FKYVIGTLEL LVAENYMIVY LNGATTRRKM PSLGWLRKCY QQIDRRLRKN 250 260 270 280 290 300 LKSLIIVHPS WFIRTLLAVT RPFISSKFSQ KIRYVFNLAE LAELVPMEYV GIPECIKQVD 310 QELNGKQDEP KNEQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins." Boyd J.M., Malstrom S., Subramanian T., Venkatesh L.K., Schaeper U., Elangovan B., D'Sa-Eipper C., Chinnadurai G. Cell 79:341-351(1994) [PubMed: 7954800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)." Rieder M.J., Livingston R.J., Daniels M.R., Chung M.-W., Miyamoto K.E., Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S., Sherwood J.K., Witrak L.A., Nickerson D.A. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-24.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[4]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed: 18088087] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114 AND THR-116, MASS SPECTROMETRY. Tissue: Platelet.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U15173 mRNA. Translation: AAC00021.1. AY268590 Genomic DNA. Translation: AAP03429.1. BC002461 mRNA. Translation: AAH02461.1.
PIR	I38864.
RefSeq	NP_004321.2.
UniGene	Hs.646490
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q12982.
PTM databases
PhosphoSite	Q12982.
Polymorphism databases
NIEHS-SNPs	Search...
Genome annotation databases
Ensembl	ENSG00000140299. Homo sapiens. [Contig view]
GeneID	663.
KEGG	hsa:663.
Organism-specific databases
H-InvDB	HIX0012297.
HGNC	HGNC:1083. BNIP2.
MIM	603292. gene.
PharmGKB	PA25393.
GenAtlas	Search...
GeneCards	Search...
GeneLynx	Search...
Phylogenomic databases
HOGENOM	Q12982.
HOVERGEN	Q12982.
Gene expression databases
ArrayExpress	Q12982.
CleanEx	HS_BNIP2.
GermOnline	ENSG00000140299. Homo sapiens.
Family and domain databases
InterPro	IPR001251. CRAL_bd_TRIO_C. [Graphical view]
Gene3D	G3DSA:3.40.525.10. CRAL_bd_TRIO_C. 1 hit.
SMART	SM00516. SEC14. 1 hit. [Graphical view]
PROSITE	PS50191. CRAL_TRIO. 1 hit. [Graphical view]
ProDom	Q12982. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

BNIP2_HUMAN

Accession

Primary (citable) accession number: Q12982

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1996
Last modified:	July 22, 2008
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)