Reviewed,
UniProtKB/Swiss-Prot Q13023 (AKAP6_HUMAN)
Last modified
July 22, 2008.
Version 68.
History...
Clusters with 100%,
90%,
50% identity |
 Documents (6) |
 Third-party data |
 Customize display | text xml rdf/xml gff fasta |
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: A-kinase anchor protein 6 Alternative name(s): Protein kinase A-anchoring protein 6 Short name(s)=PRKA6 A-kinase anchor protein 100 kDa Short name(s)=AKAP 100 mAKAP | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 2319 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes. |
| Subunit structure | Interacts with RII subunit of PKA, phosphatase 2B (calcineurin) and AKAP79. |
| Subcellular location | Sarcoplasmic reticulum. Nucleus membrane. Note= In heart muscle. Participation of multiple targeting signals allow correct intracellular targeting. These may be repeated motifs rich in basic and hydrophobic amino acids, palmitoylated/myristoylated motifs or alternatively splice targeting sequences. |
| Tissue specificity | Highly expressed in cardiac and skeletal muscle, followed by brain. |
| Domain | RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer. |
| Sequence similarities | Contains 2 spectrin repeats. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Membrane Nucleus Sarcoplasmic reticulum |
| Coding sequence diversity | Polymorphism |
| Domain | Repeat |
Gene Ontology (GO) | |
| Biological process | protein targeting Ref.1 Ref.4 Non-traceable author statement. Source: UniProtKB |
| Cellular component | nuclear envelope Ref.1 Inferred from direct assay. Source: UniProtKB sarcoplasmic reticulum Ref.4Inferred from direct assay. Source: UniProtKB |
| Molecular function | protein kinase A binding Ref.1 Non-traceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||
Molecule processing | ||||||||
|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 2319 | 2319 | A-kinase anchor protein 6 | |||||
Regions | ||||||||
| Repeat | 762 – 848 | 87 | Spectrin 1 | |||||
| Repeat | 1036 – 1150 | 115 | Spectrin 2 | |||||
| Region | 2063 – 2076 | 14 | PKA-RII subunit binding domain | |||||
| Compositional bias | 1560 – 1701 | 142 | Ser-rich | |||||
Natural variations | ||||||||
| Natural variant | 337 | 1 | A → V: dbSNP rs3742926. | |||||
| Natural variant | 408 | 1 | N → S: dbSNP rs17099240. | |||||
| Natural variant | 910 | 1 | K → M in a breast cancer sample; somatic mutation. | |||||
| Natural variant | 1192 | 1 | M → I in a breast cancer sample; somatic mutation. | |||||
| Natural variant | 1492 | 1 | A → V: dbSNP rs11845640. | |||||
| Natural variant | 1702 | 1 | E → Q in a breast cancer sample; somatic mutation. | |||||
| Natural variant | 1839 | 1 | P → T in a colorectal cancer sample; somatic mutation. | |||||
| Natural variant | 2035 | 1 | N → D: dbSNP rs1051695. | |||||
| Natural variant | 2171 | 1 | F → Y: dbSNP rs4647899. | |||||
| Natural variant | 2209 | 1 | D → H: dbSNP rs4402458. | |||||
Experimental info | ||||||||
| Sequence conflict | 974 | 1 | W → C in AAA92354. Ref.1 | |||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes." Kapiloff M.S., Shillace R.V., Westphal A.M., Scott J.D. J. Cell Sci. 112:2725-2736(1999) [PubMed: 10413680] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-1492. |
| [2] | "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed: 9205841] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [3] | "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION. |
| [4] | "Cloning and characterization of A-kinase anchor protein 100 (AKAP100). A protein that targets A-kinase to the sarcoplasmic reticulum." McCartney S., Little B.M., Langeberg L.K., Scott J.D. J. Biol. Chem. 270:9327-9333(1995) [PubMed: 7721854] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1666-2319. Tissue: Hippocampus. |
| [5] | "The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.  Velculescu V.E.Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] MET-910; ILE-1192; GLN-1702 AND THR-1839. |
Cross-references
Sequence databases | |
|---|---|
| U17195 mRNA. Translation: AAA92354.2. AB002309 mRNA. Translation: BAA20770.2. Different initiation. | |
| RefSeq | NP_004265.3. |
| UniGene | Hs.509083 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q13023. |
Genome annotation databases | |
| Ensembl | ENSG00000151320. Homo sapiens. [Contig view] |
| GeneID | 9472. |
| KEGG | hsa:9472. |
Organism-specific databases | |
| H-InvDB | HIX0011586. |
| HGNC | HGNC:376. AKAP6. |
| HPA | CAB001983. |
| MIM | 604691. gene. |
| PharmGKB | PA24670. |
| HUGE | Search... |
| GenAtlas | Search... |
| GeneCards | Search... |
| GeneLynx | Search... |
Phylogenomic databases | |
| HOGENOM | Q13023. |
| HOVERGEN | Q13023. |
Gene expression databases | |
| ArrayExpress | Q13023. |
| CleanEx | HS_AKAP6. |
Family and domain databases | |
| InterPro | IPR002017. Spectrin_repeat. [Graphical view] |
| SMART | SM00150. SPEC. 3 hits. [Graphical view] |
| ProDom | Q13023. [Graphical view] [Entries sharing at least one domain] |
| BLOCKS | Search... |
Other Resources | |
| SOURCE | Search... |
| ProtoNet | Search... |
Entry information
| Entry name | AKAP6_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q13023 Secondary accession number(s): O15028 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 14 Human chromosome 14: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |
