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Reviewed, UniProtKB/Swiss-Prot Q13349 (ITAD_HUMAN)

Last modified July 22, 2008. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Integrin alpha-D
Alternative name(s):
    Leukointegrin alpha D
    ADB2
    CD11 antigen-like family member D
    CD_antigen=CD11d
Gene names
Name: ITGAD
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length1162 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood.

Subunit structure

Heterodimer of an alpha and a beta subunit. Alpha-D associates with beta-2.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed moderately on myelomonocytic cell lines and subsets of peripheral blood leukocytes and strongly on tissue-specialized cells, including macrophages foam cells within atherosclerotic plaques, and on splenic red pulp macrophages.

Domain

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similarities

Belongs to the integrin alpha chain family.

Contains 7 FG-GAP repeats.

Contains 1 VWFA domain.

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Ontologies

Keywords

   Biological processCell adhesion
   Cellular componentMembrane
   DomainRepeat
Signal
Transmembrane
   LigandCalcium
Magnesium
   Molecular functionIntegrin
Receptor
   PTMGlycoprotein

Gene Ontology (GO)

   Biological processcell-cell adhesion

Non-traceable author statement. Source: UniProtKB

cell-matrix adhesion

Non-traceable author statement. Source: UniProtKB

immune response Ref.4

Non-traceable author statement. Source: UniProtKB

   Cellular componentintegrin complex

Traceable author statement. Source: UniProtKB

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 11621145Integrin alpha-D

Regions

Topological domain18 – 11001083Extracellular Potential
Transmembrane1101 – 112121 Potential
Topological domain1122 – 116241Cytoplasmic Potential
Repeat32 – 8554FG-GAP 1
Repeat86 – ?FG-GAP 2
Domain150 – 332183VWFA
Repeat350 – 40051FG-GAP 3
Repeat401 – 45252FG-GAP 4
Repeat454 – 51663FG-GAP 5
Repeat518 – 57659FG-GAP 6
Repeat581 – 63353FG-GAP 7
Calcium binding465 – 4739 Potential
Calcium binding530 – 5389 Potential
Calcium binding593 – 6019 Potential
Motif1127 – 11315GFFKR motif

Amino acid modifications

Glycosylation591N-linked (GlcNAc...) Potential
Glycosylation871N-linked (GlcNAc...) Potential
Glycosylation991N-linked (GlcNAc...) Potential
Glycosylation3911N-linked (GlcNAc...) Potential
Glycosylation6911N-linked (GlcNAc...) Potential
Glycosylation7331N-linked (GlcNAc...) Potential
Glycosylation8731N-linked (GlcNAc...) Potential
Glycosylation9571N-linked (GlcNAc...) Potential
Glycosylation10461N-linked (GlcNAc...) Potential
Disulfide bond67 ↔ 74 By similarity
Disulfide bond106 ↔ 124 By similarity
Disulfide bond655 ↔ 710 By similarity
Disulfide bond769 ↔ 775 By similarity
Disulfide bond846 ↔ 861 By similarity
Disulfide bond994 ↔ 1018 By similarity
Disulfide bond1023 ↔ 1028 By similarity

Experimental info

Sequence conflict8251L → V in AAB60637. Ref.3
Sequence conflict9841V → A in AAB60638. Ref.3

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Sequences

Sequence LengthMass (Da)Tools
Q13349-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: F296A1A35455D77D

FASTA1,162126,886
        10         20         30         40         50         60 
MTFGTVLLLS VLASYHGFNL DVEEPTIFQE DAGGFGQSVV QFGGSRLVVG APLEVVAANQ 

        70         80         90        100        110        120 
TGRLYDCAAA TGMCQPIPLH IRPEAVNMSL GLTLAASTNG SRLLACGPTL HRVCGENSYS 

       130        140        150        160        170        180 
KGSCLLLGSR WEIIQTVPDA TPECPHQEMD IVFLIDGSGS IDQNDFNQMK GFVQAVMGQF 

       190        200        210        220        230        240 
EGTDTLFALM QYSNLLKIHF TFTQFRTSPS QQSLVDPIVQ LKGLTFTATG ILTVVTQLFH 

       250        260        270        280        290        300 
HKNGARKSAK KILIVITDGQ KYKDPLEYSD VIPQAEKAGI IRYAIGVGHA FQGPTARQEL 

       310        320        330        340        350        360 
NTISSAPPQD HVFKVDNFAA LGSIQKQLQE KIYAVEGTQS RASSSFQHEM SQEGFSTALT 

       370        380        390        400        410        420 
MDGLFLGAVG SFSWSGGAFL YPPNMSPTFI NMSQENVDMR DSYLGYSTEL ALWKGVQNLV 

       430        440        450        460        470        480 
LGAPRYQHTG KAVIFTQVSR QWRKKAEVTG TQIGSYFGAS LCSVDVDSDG STDLILIGAP 

       490        500        510        520        530        540 
HYYEQTRGGQ VSVCPLPRGQ RVQWQCDAVL RGEQGHPWGR FGAALTVLGD VNEDKLIDVA 

       550        560        570        580        590        600 
IGAPGEQENR GAVYLFHGAS ESGISPSHSQ RIASSQLSPR LQYFGQALSG GQDLTQDGLM 

       610        620        630        640        650        660 
DLAVGARGQV LLLRSLPVLK VGVAMRFSPV EVAKAVYRCW EEKPSALEAG DATVCLTIQK 

       670        680        690        700        710        720 
SSLDQLGDIQ SSVRFDLALD PGRLTSRAIF NETKNPTLTR RKTLGLGIHC ETLKLLLPDC 

       730        740        750        760        770        780 
VEDVVSPIIL HLNFSLVREP IPSPQNLRPV LAVGSQDLFT ASLPFEKNCG QDGLCEGDLG 

       790        800        810        820        830        840 
VTLSFSGLQT LTVGSSLELN VIVTVWNAGE DSYGTVVSLY YPAGLSHRRV SGAQKQPHQS 

       850        860        870        880        890        900 
ALRLACETVP TEDEGLRSSR CSVNHPIFHE GSNGTFIVTF DVSYKATLGD RMLMRASASS 

       910        920        930        940        950        960 
ENNKASSSKA TFQLELPVKY AVYTMISRQE ESTKYFNFAT SDEKKMKEAE HRYRVNNLSQ 

       970        980        990       1000       1010       1020 
RDLAISINFW VPVLLNGVAV WDVVMEAPSQ SLPCVSERKP PQHSDFLTQI SRSPMLDCSI 

      1030       1040       1050       1060       1070       1080 
ADCLQFRCDV PSFSVQEELD FTLKGNLSFG WVRETLQKKV LVVSVAEITF DTSVYSQLPG 

      1090       1100       1110       1120       1130       1140 
QEAFMRAQME MVLEEDEVYN AIPIIMGSSV GALLLLALIT ATLYKLGFFK RHYKEMLEDK 

      1150       1160 
PEDTATFSGD DFSCVAPNVP LS

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References

[1]"A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3."
Van der Vieren M., Le Trong H., Wood C.L., Moore P.F., St John T., Staunton D.E., Gallatin W.M.
Immunity 3:683-690(1995) [PubMed: 8777714] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Spleen.
[2]"Structural and functional characterization of the leukocyte integrin gene CD11d. Essential role of Sp1 and Sp3."
Noti J.D., Johnson A.K., Dillon J.D.
J. Biol. Chem. 275:8959-8969(2000) [PubMed: 10722744] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-235.
[3]"Cloning and chromosomal localization of a novel gene-encoding a human beta 2-integrin alpha subunit."
Wong D.A., Davis E.M., LeBeau M., Springer T.A.
Gene 171:291-294(1996) [PubMed: 8666289] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 467-537; 571-602; 633-666; 788-834 AND 910-1125.
[4]"Alphadbeta2 integrin is expressed on human eosinophils and functions as an alternative ligand for vascular cell adhesion molecule 1 (VCAM-1)."
Grayson M.H., Van der Vieren M., Sterbinsky S.A., Michael Gallatin W., Hoffman P.A., Staunton D.E., Bochner B.S.
J. Exp. Med. 188:2187-2191(1998) [PubMed: 9841932] [Abstract]
Cited for: INTERACTION WITH VCAM1.
[5]"The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a binding interface between I domain and VCAM-1."
Van der Vieren M., Crowe D.T., Hoekstra D., Vazeux R., Hoffman P.A., Grayson M.H., Bochner B.S., Gallatin W.M., Staunton D.E.
J. Immunol. 163:1984-1990(1999) [PubMed: 10438935] [Abstract]
Cited for: INTERACTION WITH VCAM1.
+Additional computationally mapped references.

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Cross-references

Sequence databases

U37028 mRNA. Translation: AAB38547.1.
U40274 Genomic DNA. Translation: AAB60634.1. Sequence problems.
U40275 Genomic DNA. Translation: AAB60635.1.
U40276 Genomic DNA. Translation: AAB60636.1.
U40277 Genomic DNA. Translation: AAB60637.1.
U40279, U40278 Genomic DNA. Translation: AAB60638.1.
AF187881 Genomic DNA. Translation: AAF62875.1.
UniGeneHs.679163

3D structure databases

HSSPHSSP built from PDB template 1BHQ based on UniProtKB P11215.
ModBaseSearch...

Genome annotation databases

EnsemblENSG00000156886. Homo sapiens. [Contig view]

Organism-specific databases

H-InvDBHIX0012989.
HIX0079776.
HGNCHGNC:6146. ITGAD.
MIM602453. gene.
PharmGKBPA29946.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ13349.
HOVERGENQ13349.

Gene expression databases

ArrayExpressQ13349.
CleanExHS_ITGAD.
GermOnlineENSG00000156886. Homo sapiens.

Family and domain databases

InterProIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR013513. Integrin_alpha_C.
IPR002035. VWF_A.
[Graphical view]
PfamPF01839. FG-GAP. 3 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSPR01185. INTEGRINA.
PR00453. VWFADOMAIN.
SMARTSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
PROSITEPS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProDomQ13349.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

LinkHubQ13349.
SOURCESearch...
ProtoNetSearch...

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Entry information

Entry nameITAD_HUMAN
AccessionPrimary (citable) accession number: Q13349
Secondary accession number(s): Q15575, Q15576
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: July 22, 2008
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents