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Reviewed, UniProtKB/Swiss-Prot Q13520 (AQP6_HUMAN)

Last modified July 22, 2008. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Aquaporin-6
      Short name(s)=AQP-6
Alternative name(s):
    Aquaporin-2-like
      Short name(s)=hKID
Gene names
Name: AQP6
Synonyms: AQP2L
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length282 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism By similarity.

Subcellular location

Cytoplasmic vesicle membrane; Multi-pass membrane proteinBy similarity.

Domain

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similarities

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]

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Ontologies

Keywords

   Biological processTransport
   Cellular componentCytoplasmic vesicle
Membrane
   DomainRepeat
Transmembrane
   Technical term3D-structure

Gene Ontology (GO)

   Biological processexcretion Ref.1

Traceable author statement. Source: ProtInc

transport Ref.1

Traceable author statement. Source: ProtInc

   Cellular componentintegral to plasma membrane Ref.1

Traceable author statement. Source: ProtInc

   Molecular functionwater channel activity Ref.1

Traceable author statement. Source: ProtInc

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 282282Aquaporin-6

Regions

Topological domain1 – 3030Cytoplasmic Potential
Transmembrane31 – 4818 Potential
Topological domain49 – 546Extracellular Potential
Transmembrane55 – 7319 Potential
Topological domain74 – 9926Cytoplasmic Potential
Transmembrane100 – 12122 Potential
Topological domain122 – 14120Extracellular Potential
Transmembrane142 – 16221 Potential
Topological domain163 – 1686Cytoplasmic Potential
Transmembrane169 – 18820 Potential
Topological domain189 – 21426Extracellular Potential
Transmembrane215 – 23622 Potential
Topological domain237 – 28246Cytoplasmic Potential
Motif82 – 843NPA 1
Motif196 – 1983NPA 2

Secondary structure

1 ......................... 282
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
Q13520-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 990BECB5D931ADD3

FASTA28229,563
        10         20         30         40         50         60 
MDAEVPGGRG WASMLACRLW KAISRALFAE FLATGLYVFF GVGSVMRWPT ALPSVLQIAI 

        70         80         90        100        110        120 
TFNLVTAMAV QVTWKTSGAH ANPAVTLAFL VGSHISLPRA VAYVAAQLVG ATVGAALLYG 

       130        140        150        160        170        180 
VMPGDIRETL GINVVRNSVS TGQAVAVELL LTLQLVLCVF ASTDSRQTSG SPATMIGISW 

       190        200        210        220        230        240 
ALGHLIGILF TGCSMNPARS FGPAIIIGKF TVHWVFWVGP LMGALLASLI YNFVLFPDTK 

       250        260        270        280 
TLAQRLAILT GTVEVGTGAR AGAEPLKKES QPGSGAVEME SV

« Hide

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References

[1]"cDNA cloning and gene structure of a novel water channel expressed exclusively in human kidney: evidence for a gene cluster of aquaporins at chromosome locus 12q13."
Ma T., Yang B., Kuo W.L., Verkman A.S.
Genomics 35:543-550(1996) [PubMed: 8812490] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Kidney.

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Cross-references

Sequence databases

U48408 mRNA. Translation: AAB41566.1.
RefSeqNP_001643.2.
UniGeneHs.54505

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1S6Emodel-A1-282[»]
ModBaseSearch...

Genome annotation databases

EnsemblENSG00000086159. Homo sapiens. [Contig view]
GeneID363.
KEGGhsa:363.

Organism-specific databases

HGNCHGNC:639. AQP6.
MIM601383. gene.
PharmGKBPA24924.
GenAtlasSearch...
GeneCardsSearch...
GeneLynxSearch...

Phylogenomic databases

HOGENOMQ13520.
HOVERGENQ13520.

Gene expression databases

ArrayExpressQ13520.
CleanExHS_AQP6.
GermOnlineENSG00000086159. Homo sapiens.

Family and domain databases

InterProIPR012269. Aquaporin.
IPR000425. MIP.
[Graphical view]
Gene3DG3DSA:1.20.1080.10. MIP. 1 hit.
PANTHERPTHR19139. MIP. 1 hit.
PfamPF00230. MIP. 1 hit.
[Graphical view]
PRINTSPR00783. MINTRINSICP.
ProDomPD000295. MIP. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR00861. MIP. 1 hit.
PROSITEPS00221. MIP. 1 hit.
[Graphical view]
BLOCKSSearch...

Other Resources

SOURCESearch...
ProtoNetSearch...

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Entry information

Entry nameAQP6_HUMAN
AccessionPrimary (citable) accession number: Q13520
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 22, 2008
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents