Reviewed, UniProtKB/Swiss-Prot Q13685 (AAMP_HUMAN)

Names and origin

Protein names

Recommended name:
    Angio-associated migratory cell protein

Gene names

Name:

AAMP

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May have a function in migrating cells.
Tissue specificity	Expressed in blood vessels. Strongly expressed in endothelial cells, cytotrophoblasts, and poorly differentiated colon adenocarcinoma cells found in lymphatics.
Sequence similarities	Contains 8 WD repeats.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat WD repeat
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular function	heparin binding Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 434	434	Angio-associated migratory cell protein
Regions
	Repeat	89 – 129	41	WD 1
	Repeat	132 – 171	40	WD 2
	Repeat	173 – 212	40	WD 3
	Repeat	214 – 254	41	WD 4
	Repeat	258 – 299	42	WD 5
	Repeat	315 – 354	40	WD 6
	Repeat	356 – 395	40	WD 7
	Repeat	398 – 433	36	WD 8
	Compositional bias	53 – 59	7	Poly-Glu
Natural variations
	Natural variant	250	1	I → V: dbSNP rs2305835.

Sequences

	Sequence		Length	Mass (Da)
	Q13685-1 [UniParc]. Last modified April 26, 2005. Version 2. Checksum: A7B8314442EBAF15	FASTA	434	46,751
	10 20 30 40 50 60 MESESESGAA ADTPPLETLS FHGDEEIIEV VELDPGPPDP DDLAQEMEDV DFEEEEEEEG 70 80 90 100 110 120 NEEGWVLEPQ EGVVGSMEGP DDSEVTFALH SASVFCVSLD PKTNTLAVTG GEDDKAFVWR 130 140 150 160 170 180 LSDGELLFEC AGHKDSVTCA GFSHDSTLVA TGDMSGLLKV WQVDTKEEVW SFEAGDLEWM 190 200 210 220 230 240 EWHPRAPVLL AGTADGNTWM WKVPNGDCKT FQGPNCPATC GRVLPDGKRA VVGYEDGTIR 250 260 270 280 290 300 IWDLKQGSPI HVLKGTEGHQ GPLTCVAANQ DGSLILTGSV DCQAKLVSAT TGKVVGVFRP 310 320 330 340 350 360 ETVASQPSLG EGEESESNSV ESLGFCSVMP LAAVGYLDGT LAIYDLATQT LRHQCQHQSG 370 380 390 400 410 420 IVQLLWEAGT AVVYTCSLDG IVRLWDARTG RLLTDYRGHT AEILDFALSK DASLVVTTSG 430 DHKAKVFCVQ RPDR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a new immunoglobulin superfamily protein expressed in blood vessels with a heparin-binding consensus sequence." Beckner M.E., Krutzsch H.C., Stracke M.L., Williams S.T., Gallardo J.A., Liotta L.A. Cancer Res. 55:2140-2149(1995) [PubMed: 7743515] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. Tissue: Brain.
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary and Skin.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M95627 mRNA. Translation: AAA68889.1. Different initiation. CR456755 mRNA. Translation: CAG33036.1. Different initiation. BC008809 mRNA. Translation: AAH08809.2. BC020244 mRNA. Translation: AAH20244.1. BC039866 mRNA. Translation: AAH39866.2.
PIR	I39383.
RefSeq	NP_001078.2.
UniGene	Hs.83347
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000127837. Homo sapiens. [Contig view]
GeneID	14.
KEGG	hsa:14.
Organism-specific databases
HGNC	HGNC:18. AAMP.
HPA	CAB017717.
MIM	603488. gene.
PharmGKB	PA24365.
GenAtlas	Search...
GeneCards	Search...
GeneLynx	Search...
Phylogenomic databases
HOGENOM	Q13685.
HOVERGEN	Q13685.
Gene expression databases
CleanEx	HS_AAMP.
GermOnline	ENSG00000127837. Homo sapiens.
Family and domain databases
InterPro	IPR015943. WD40/YVTN_repeat-like. IPR001680. WD40_repeat. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 2 hits.
Pfam	PF00400. WD40. 6 hits. [Graphical view]
PRINTS	PR00320. GPROTEINBRPT.
SMART	SM00320. WD40. 8 hits. [Graphical view]
PROSITE	PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 6 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProDom	Q13685. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

AAMP_HUMAN

Accession

Primary (citable) accession number: Q13685
Secondary accession number(s): Q8WUJ9, Q96H92

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	April 26, 2005
Last modified:	July 22, 2008
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)