Reviewed, UniProtKB/Swiss-Prot Q13686 (ALKB1_HUMAN)

Names and origin

Protein names

Recommended name:
    Alkylated DNA repair protein alkB homolog 1

Gene names

Name:	ALKBH1
Synonyms:	ABH, ALKBH

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Tissue specificity	Ubiquitous.
Sequence similarities	Belongs to the alkB family.
Sequence caution	CAA63047.1 sequence differs from that shown. Reason: Frameshift at several positions.

Ontologies

Gene Ontology (GO)
Biological process	DNA dealkylation Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 389	389	Alkylated DNA repair protein alkB homolog 1
Experimental info
	Sequence conflict	133	1	K → T in CAA63047. Ref.1
	Sequence conflict	266 – 267	2	TA → PP in CAA63047. Ref.1
	Sequence conflict	388	1	D → H in AAH25787. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q13686-1 [UniParc]. Last modified December 1, 2000. Version 2. Checksum: 539C4CE41D2D8AEC	FASTA	389	43,832
	10 20 30 40 50 60 MGKMAAAVGS VATLATEPGE DAFRKLFRFY RQSRPGTADL EGVIDFSAAH AARGKGPGAQ 70 80 90 100 110 120 KVIKSQLNVS SVSEQNAYRA GLQPVSKWQA YGLKGYPGFI FIPNPFLPGY QWHWVKQCLK 130 140 150 160 170 180 LYSQKPNVCN LDKHMSKEET QDLWEQSKEF LRYKEATKRR PRSLLEKLRW VTVGYHYNWD 190 200 210 220 230 240 SKKYSADHYT PFPSDLGFLS EQVAAACGFE DFRAEAGILN YYRLDSTLGI HVDRSELDHS 250 260 270 280 290 300 KPLLSFSFGQ SAIFLLGGLQ RDEAPTAMFM HSGDIMIMSG FSRLLNHAVP RVLPNPEGEG 310 320 330 340 350 360 LPHCLEAPLP AVLPRDSMVE PCSMEDWQVC ASYLKTARVN MTVRQVLATD QNFPLEPIED 370 380 EKRDISTEGF CHLDDQNSEV KRARINPDS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and functional analysis of a human cDNA encoding an Escherichia coli AlkB homolog, a protein involved in DNA alkylation damage repair." Wei Y.F., Carter K.C., Wang R.P., Shell B.K. Nucleic Acids Res. 24:931-937(1996) [PubMed: 8600462] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Synovial sarcoma.
[2]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X91992 mRNA. Translation: CAA63047.1. Frameshift. AC008044 Genomic DNA. Translation: AAF01478.1. BC025787 mRNA. Translation: AAH25787.1.
PIR	S64736.
RefSeq	NP_006011.2.
UniGene	Hs.94542
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000100601. Homo sapiens. [Contig view]
GeneID	8846.
KEGG	hsa:8846.
NMPDR	fig|9606.3.peg.9945.
Organism-specific databases
HGNC	HGNC:17911. ALKBH1.
MIM	605345. gene.
GenAtlas	Search...
GeneCards	Search...
GeneLynx	Search...
Phylogenomic databases
HOGENOM	Q13686.
HOVERGEN	Q13686.
Gene expression databases
ArrayExpress	Q13686.
CleanEx	HS_ALKBH1.
GermOnline	ENSG00000100601. Homo sapiens.
Family and domain databases
InterPro	IPR004574. Alkb. [Graphical view]
TIGRFAMs	TIGR00568. alkb. 1 hit.
ProDom	Q13686. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

ALKB1_HUMAN

Accession

Primary (citable) accession number: Q13686
Secondary accession number(s): Q8TAU1, Q9ULA7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	July 22, 2008
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)