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Reviewed, UniProtKB/Swiss-Prot Q15389 (ANGP1_HUMAN)

Last modified July 22, 2008. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Angiopoietin-1
      Short name=ANG-1
Gene names
Name: ANGPT1
Synonyms: KIAA0003
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development.

Subcellular location

Secreted.

Post-translational modification

Glycosylated.

Miscellaneous

It may have a potential therapeutic utility since it can be used for specifically targeting tumor vasculature or for promoting angiogenic processes in certain organs such as an ischemic heart.

Sequence similarities

Contains 1 fibrinogen C-terminal domain.

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Ontologies

Keywords

   Biological processAngiogenesis
Differentiation
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainCoiled coil
Signal
   Molecular functionDevelopmental protein
   PTMGlycoprotein

Gene Ontology (GO)

   Biological processsignal transduction

Traceable author statement. Source: ProtInc

   Cellular componentextracellular region

Inferred from Experiment. Source: Reactome

   Molecular functionreceptor binding Ref.1

Traceable author statement. Source: ProtInc

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Signal peptide1 – 1515 Potential
Chain16 – 498483Angiopoietin-1

Regions

Domain284 – 498215Fibrinogen C-terminal
Coiled coil81 – 11939 Potential
Coiled coil153 – 261109 Potential

Amino acid modifications

Glycosylation921N-linked (GlcNAc...) Potential
Glycosylation1221N-linked (GlcNAc...) Potential
Glycosylation1541N-linked (GlcNAc...) Potential
Glycosylation2431N-linked (GlcNAc...) Potential
Glycosylation2951N-linked (GlcNAc...) Potential
Disulfide bond286 ↔ 315 By similarity
Disulfide bond439 ↔ 452 By similarity

Natural variations

Natural variant2691Missing in cell line T98G; may be due to exon slippage.

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Sequences

Sequence LengthMass (Da)Tools
Q15389-1 [UniParc].

Last modified January 1, 1998. Version 2.
Checksum: 5D5FA63AEF6BE920

FASTA49857,513
        10         20         30         40         50         60 
MTVFLSFAFL AAILTHIGCS NQRRSPENSG RRYNRIQHGQ CAYTFILPEH DGNCRESTTD 

        70         80         90        100        110        120 
QYNTNALQRD APHVEPDFSS QKLQHLEHVM ENYTQWLQKL ENYIVENMKS EMAQIQQNAV 

       130        140        150        160        170        180 
QNHTATMLEI GTSLLSQTAE QTRKLTDVET QVLNQTSRLE IQLLENSLST YKLEKQLLQQ 

       190        200        210        220        230        240 
TNEILKIHEK NSLLEHKILE MEGKHKEELD TLKEEKENLQ GLVTRQTYII QELEKQLNRA 

       250        260        270        280        290        300 
TTNNSVLQKQ QLELMDTVHN LVNLCTKEGV LLKGGKREEE KPFRDCADVY QAGFNKSGIY 

       310        320        330        340        350        360 
TIYINNMPEP KKVFCNMDVN GGGWTVIQHR EDGSLDFQRG WKEYKMGFGN PSGEYWLGNE 

       370        380        390        400        410        420 
FIFAITSQRQ YMLRIELMDW EGNRAYSQYD RFHIGNEKQN YRLYLKGHTG TAGKQSSLIL 

       430        440        450        460        470        480 
HGADFSTKDA DNDNCMCKCA LMLTGGWWFD ACGPSNLNGM FYTAGQNHGK LNGIKWHYFK 

       490 
GPSYSLRSTT MMIRPLDF

« Hide

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References

« Hide 'large scale' references
[1]"Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning."
Davis S., Aldrich T.H., Jones P.F., Acheson A., Compton D.L., Jain V., Ryan T.E., Bruno J., Radziejewski C., Maisonpierre P.C., Yancopoulos G.D.
Cell 87:1161-1169(1996) [PubMed: 8980223] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-269 DEL.
Tissue: Fetal lung.
[2]"Human angiopoietin-1 mRNA variant form."
Nakatsukasa M., Komai K., Shiozawa S.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-269 DEL.
[3]"Human angiopoietin-1 mRNA variant forms."
Shan Z.X., Yu X.Y., Lin Q.Y., Fu Y.H., Tan H.H., Zheng M., Lin S.G.
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-269 DEL.
[4]"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
DNA Res. 1:27-35(1994) [PubMed: 7584026] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Bone marrow.
[5]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract]
Cited for: SEQUENCE REVISION.
+Additional computationally mapped references.

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Web resources

Wikipedia

Angiopoietin entry

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Cross-references

Sequence databases

U83508 mRNA. Translation: AAB50557.1.
AB084454 mRNA. Translation: BAB91325.1.
AY121504 mRNA. Translation: AAM81745.1.
AY124380 mRNA. Translation: AAM92271.1.
D13628 mRNA. Translation: BAA02793.2. Different initiation.
RefSeqNP_001137.2.
UniGeneHs.369675

3D structure databases

HSSPHSSP built from PDB template 1FZD based on UniProtKB P02671.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:6046N.

PTM databases

PhosphoSiteQ15389.

Genome annotation databases

EnsemblENSG00000154188. Homo sapiens. [Contig view]
GeneID284.
KEGGhsa:284.

Organism-specific databases

H-InvDBHIX0007720.
HGNCHGNC:484. ANGPT1.
HPACAB017815.
MIM601667. gene.
PharmGKBPA24791.
HUGESearch...
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ15389.
HOVERGENQ15389.

Gene expression databases

ArrayExpressQ15389.
CleanExHS_ANGPT1.
GermOnlineENSG00000154188. Homo sapiens.

Family and domain databases

InterProIPR002181. Fibrinogen_a/b/g_C.
IPR014716. Fibrinogen_a/b/g_C_1.
[Graphical view]
Gene3DG3DSA:3.90.215.10. Fibrinogen_a/b/g_C_1. 1 hit.
PfamPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTSM00186. FBG. 1 hit.
[Graphical view]
PROSITEPS00514. FIBRIN_AG_C_DOMAIN. 1 hit.
[Graphical view]
ProDomQ15389.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

SOURCESearch...
ProtoNetSearch...

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Entry information

Entry nameANGP1_HUMAN
AccessionPrimary (citable) accession number: Q15389
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: July 22, 2008
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents