Reviewed, UniProtKB/Swiss-Prot Q16613 (SNAT_HUMAN)

Names and origin

Protein names

Recommended name:
    Serotonin N-acetyltransferase
      Short name=Serotonin acetylase
    EC=2.3.1.87
Alternative name(s):
    Aralkylamine N-acetyltransferase
      Short name=AA-NAT

Gene names

Name:	AANAT
Synonyms:	SNAT

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes the N-acetylation of serotonin into N-acetylserotonin.
Catalytic activity	Acetyl-CoA + a 2-arylethylamine = CoA + an N-acetyl-2-arylethylamine.
Pathway	Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.
Subunit structure	Monomer By similarity.
Tissue specificity	Highly expressed in pineal gland and retina.
Sequence similarities	Belongs to the acetyltransferase family. AANAT subfamily. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Molecular function	Acyltransferase Transferase
Gene Ontology (GO)
Biological process	circadian rhythm Ref.1 Traceable author statement. Source: ProtInc metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	aralkylamine N-acetyltransferase activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	Serotonin N-acetyltransferase		PRO_0000074580
Regions
	Domain	35 – 194	160	N-acetyltransferase
Sites
	Active site	168	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q16613-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 7476612F3661E0D5	FASTA	207	23,344
	10 20 30 40 50 60 MSTQSTHPLK PEAPRLPPGI PESPSCQRRH TLPASEFRCL TPEDAVSAFE IEREAFISVL 70 80 90 100 110 120 GVCPLYLDEI RHFLTLCPEL SLGWFEEGCL VAFIIGSLWD KERLMQESLT LHRSGGHIAH 130 140 150 160 170 180 LHVLAVHRAF RQQGRGPILL WRYLHHLGSQ PAVRRAALMC EDALVPFYER FSFHAVGPCA 190 200 ITVGSLTFME LHCSLRGHPF LRRNSGC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression." Coon S.L., Mazuruk K., Bernard M., Roseboom P., Klein D.C., Rodriguez I.R. Genomics 34:76-84(1996) [PubMed: 8661026] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Testis.
+	Additional computationally mapped references.

Web resources

SHMPD

The Singapore human mutation and polymorphism database

Cross-references

Sequence databases
EMBLGenBankDDBJ	U40391 Genomic DNA. Translation: AAC50555.1. U40347 mRNA. Translation: AAC50554.1. BC069434 mRNA. Translation: AAH69434.1. BC092430 mRNA. Translation: AAH92430.1. BC126332 mRNA. Translation: AAI26333.1. BC126334 mRNA. Translation: AAI26335.1.
RefSeq	NP_001079.1.
UniGene	Hs.431417
3D structure databases
HSSP	HSSP built from PDB template 1B6B based on UniProtKB Q29495.
SMR	Q16613. Positions 19-196.
ModBase	Search...
PTM databases
PhosphoSite	Q16613.
Genome annotation databases
Ensembl	ENSG00000129673. Homo sapiens. [Contig view]
GeneID	15.
KEGG	hsa:15.
Organism-specific databases
HGNC	HGNC:19. AANAT.
HPA	CAB001705.
MIM	600950. gene+phenotype.
PharmGKB	PA24366.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q16613.
HOVERGEN	Q16613.
Gene expression databases
CleanEx	HS_AANAT.
GermOnline	ENSG00000129673. Homo sapiens.
Family and domain databases
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR000182. GCN5-rel_AcTrfase. [Graphical view]
Gene3D	G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
Pfam	PF00583. Acetyltransf_1. 1 hit. [Graphical view]
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	35.
SOURCE	Search...

Entry information

Entry name

SNAT_HUMAN

Accession

Primary (citable) accession number: Q16613
Secondary accession number(s): A0AVF2, Q562F4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1996
Last modified:	November 25, 2008
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)