Reviewed, UniProtKB/Swiss-Prot Q1KL11 (HXA2A_FUGRU)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A2a

Gene names

Name:

hoxa2a

Organism

Fugu rubripes (Japanese pufferfish) (Takifugu rubripes)

Taxonomic identifier

31033 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Tetraodontiformes › Tetradontoidea › Tetraodontidae › Takifugu

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	NucleusBy similarity.
Sequence similarities	Belongs to the Antp homeobox family. Proboscipedia subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 363	363	Homeobox protein Hox-A2a
Regions
	DNA binding	137 – 196	60	Homeobox
	Motif	88 – 93	6	Antp-type hexapeptide

Sequences

	Sequence		Length	Mass (Da)
	Q1KL11-1 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: 51673DF29AC0EC56	FASTA	363	39,783
	10 20 30 40 50 60 MNYEFERESG FINSQPSLAE CLTSFPPVAD SFQSSSIKSS TLSRPTLIPP PFEQTIPSLN 70 80 90 100 110 120 PGSHPRHGRP RHSPDGCSPL PTASLPPEYP WMREKKASKR NHLPNSTTTT ISNGPVCFSP 130 140 150 160 170 180 KGSPEIVESA GGGGGGSRRL RTAYTNTQLL ELEKEFHFNK YLCRPRRVEI AALLDLTERQ 190 200 210 220 230 240 VKVWFQNRRM KHKRQTQSKE NHNAEGKGPS TEEGIHSDEE DEAPVFDRSG ALLERDTCSF 250 260 270 280 290 300 QKKSHGSAQQ HHNSVSMGFA AAPLNSNDKN LKHFPNPSPT VPGCMSTIGP GSASGPDNSD 310 320 330 340 350 360 SPPALDVSIH DFQPFSSDSC LQLSDAASPS LSESLDSPVD ISTDSFYFFS ESLTTIDLQH LSY

References

[1]

"Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters." Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B. Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006) [PubMed: 16636282] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ481663 Genomic DNA. Translation: ABF22383.1.
3D structure databases
SMR	Q1KL11. Positions 139-195.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q1KL11.
Family and domain databases
InterPro	IPR001827. Antennapedia. IPR001356. Homeobox. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
ProDom	PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

HXA2A_FUGRU

Accession

Primary (citable) accession number: Q1KL11

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	May 30, 2006
Last modified:	July 22, 2008
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)