Reviewed, UniProtKB/Swiss-Prot Q1ZXC6 (ELP3_DICDI)

Names and origin

Protein names

Recommended name:
    Probable elongator complex protein 3
    EC=2.3.1.48

Gene names

Name:	elp3
ORF Names:	DDB_0231756

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	559 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. May also have a methyltransferase activity By similarity.
Catalytic activity	Acetyl-CoA + histone = CoA + acetylhistone.
Cofactor	Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.
Subunit structure	Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit By similarity.
Subcellular location	NucleusBy similarity.
Sequence similarities	Belongs to the ELP3 family. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	Iron Iron-sulfur Metal-binding S-adenosyl-L-methionine
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 559	559	Probable elongator complex protein 3
Regions
	Domain	408 – 559	152	N-acetyltransferase
Sites
	Metal binding	111	1	Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
	Metal binding	121	1	Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
	Metal binding	124	1	Iron-sulfur (4Fe-4S-S-AdoMet) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1ZXC6-1 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: B69CD84788F24AE2	FASTA	559	63,210
	10 20 30 40 50 60 MSLMNDPRPV SKKAGAKPVY GKNTPQFTKT VGEIVNALIN AYKEGKKVNL LKIKTELAAK 70 80 90 100 110 120 NSLSDQPKSV DIISAIPESY KNTLLPLLKA KPVRTASGIA VVAVMCKPHR CPHLAMTGNI 130 140 150 160 170 180 CVYCPGGPDS DFEYSTQSYT GYEPTSMRAI RARYNPFLQT RHRIDQLKRL GHNVEKVEFI 190 200 210 220 230 240 IMGGTFMSLP SDYRDYFIRN LHDALSGHTS NNVAEAVKYS EQSNVKCVGI TIETRPDHCL 250 260 270 280 290 300 KLHLSNMLTY GCTRLEIGVQ SVFEDIARDT NRGHTVRAVL ESFQLAKDSG FKVVAHMMPD 310 320 330 340 350 360 LPNMGMERDI YGFMEFFENP AFRADGLKIY PTLVIRGTGL YELWKTGTYK NYSPDSLVDL 370 380 390 400 410 420 IAKVLALVPP WTRIYRIQRD IPMPLVTSGV EYGNLRELCL ARMKDFGTKC RDVRTREVGI 430 440 450 460 470 480 QEVHHKIKPD QVELIRRDYV ANGGWETFLS FEDPKQDILI GLLRLRKCSE TSFRPELKEN 490 500 510 520 530 540 CSIVRELHVY GSVVGIHNRD PTKFQHQGYG TLLMEEAERI AREEHGSIKL AVIAGVGTRH 550 YYRKLGYELD GVYVSKYLG

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000153 Genomic DNA. Translation: EAS66831.1.
RefSeq	XP_001134514.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4238187.
KEGG	ddi:DDB_0231756.
Organism-specific databases
dictyBase	DDB0231756. elp3.
Family and domain databases
InterPro	IPR006638. Elp3/MiaB/NifB. IPR000182. GCN5-rel_AcTrfase. IPR005910. Hist_AcTrfase_ELP3. IPR007197. Radical_SAM. [Graphical view]
Pfam	PF00583. Acetyltransf_1. 1 hit. PF04055. Radical_SAM. 1 hit. [Graphical view]
PIRSF	PIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMART	SM00729. Elp3. 1 hit. [Graphical view]
TIGRFAMs	TIGR01211. ELP3. 1 hit.
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProDom	Q1ZXC6. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ELP3_DICDI

Accession

Primary (citable) accession number: Q1ZXC6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 2, 2006
Last modified:	September 2, 2008
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)