Reviewed, UniProtKB/Swiss-Prot Q1ZXD3 (PSMD3_DICDI)

Names and origin

Protein names

Recommended name:
    26S proteasome non-ATPase regulatory subunit 3
      Short name=26S proteasome regulatory subunit S3

Gene names

Name:	psmD3
ORF Names:	DDB_0232980

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	504 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins By similarity.
Subunit structure	The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively By similarity.
Sequence similarities	Belongs to the proteasome subunit S3 family. Contains 1 PCI domain.

Ontologies

Keywords
Cellular component	Proteasome
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	centrosome Ref.2 Inferred from direct assay. Source: dictyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 504	504	26S proteasome non-ATPase regulatory subunit 3
Regions
	Domain	326 – 431	106	PCI
	Compositional bias	121 – 125	5	Poly-Ser

Sequences

	Sequence		Length	Mass (Da)
	Q1ZXD3-1 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: EF6F2053561AC752	FASTA	504	57,439
	10 20 30 40 50 60 MADIEMSEAS KTPVVAEEVV DPVQKANEAS LLTFADLKKN IGLIDKGVDT KEMRFIISVL 70 80 90 100 110 120 RQTQSIRKKL NYKVLNQIVN FAFSHQNHAT KKNFLLSFLK SDGSSMDIDS TTQAEKETTP 130 140 150 160 170 180 SSSSSHLNIE VESYIHLLVL IYLIDQKKYE DATKCSSALM ETVQSNTRIT LYPLSSKIFF 190 200 210 220 230 240 YYSLSYEMTN NLHEVRSTLL SALRTATLRH NDEGQATIIN LLLRNYLEYN LFEQADKLLA 250 260 270 280 290 300 NTQFPESASS NQFARYFYYQ GRIRAIQLEY AESFKFLTQA IRKAPQNTAG GFRRTVYKLL 310 320 330 340 350 360 SIVQLLMGEI PERNTFSQKQ LKIALKPYFH LTEAVRVGDL GSFNQALEQN SDIFKSDQTF 370 380 390 400 410 420 TLVQRLRSNV IKAGLKKLNT AYSRISFNDI CTKLKFDGTT QDIMFIIAKT IKDGVIDATI 430 440 450 460 470 480 NYEGGYLQSR ENIDAYSTQE PLHAFSNRID ICLKIHNDSL KAMRFHPDLN KAETEKIAEV 490 500 AKTIKEEMER QAEESSDNEG DSDF

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

[2]

"Identification of novel centrosomal proteins in Dictyostelium discoideum by comparative proteomic approaches." Reinders Y., Schulz I., Graef R., Sickmann A. J. Proteome Res. 5:589-598(2006) [PubMed: 16512674] [Abstract] Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000119 Genomic DNA. Translation: EAS66838.1.
RefSeq	XP_001134521.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4238178.
KEGG	ddi:DDB_0232980.
Organism-specific databases
dictyBase	DDB0232980. psmD3.
Family and domain databases
InterPro	IPR013586. 26S_Psome_reg_C. IPR013143. PAM. IPR000717. PCI. IPR000082. SEA. [Graphical view]
Pfam	PF01399. PCI. 1 hit. PF08375. Rpn3_C. 1 hit. [Graphical view]
SMART	SM00753. PAM. 1 hit. SM00088. PINT. 1 hit. [Graphical view]
ProDom	Q1ZXD3. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

PSMD3_DICDI

Accession

Primary (citable) accession number: Q1ZXD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 2, 2006
Last modified:	September 23, 2008
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)