Reviewed, UniProtKB/Swiss-Prot Q28309 (AA3R_CANFA)

Names and origin

Protein names

Recommended name:
    Adenosine A3 receptor

Gene names

Name:

ADORA3

Organism

Canis familiaris (Dog)

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein Lipoprotein Palmitate Phosphoprotein
Gene Ontology (GO)
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 314	314	Adenosine A3 receptor
Regions
	Topological domain	1 – 14	14	Extracellular Potential
	Transmembrane	15 – 37	23	1 Potential
	Topological domain	38 – 48	11	Cytoplasmic Potential
	Transmembrane	49 – 72	24	2 Potential
	Topological domain	73 – 84	12	Extracellular Potential
	Transmembrane	85 – 106	22	3 Potential
	Topological domain	107 – 126	20	Cytoplasmic Potential
	Transmembrane	127 – 148	22	4 Potential
	Topological domain	149 – 177	29	Extracellular Potential
	Transmembrane	178 – 198	21	5 Potential
	Topological domain	199 – 231	33	Cytoplasmic Potential
	Transmembrane	232 – 255	24	6 Potential
	Topological domain	256 – 261	6	Extracellular Potential
	Transmembrane	262 – 284	23	7 Potential
	Topological domain	285 – 314	30	Cytoplasmic Potential
Amino acid modifications
	Modified residue	305	1	Phosphoserine By similarity
	Lipidation	303	1	S-palmitoyl cysteine Potential
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	12	1	N-linked (GlcNAc...) Potential
	Glycosylation	160	1	N-linked (GlcNAc...) Potential
	Disulfide bond	83 ↔ 166		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q28309-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 62BB04E558BA102A	FASTA	314	35,903
	10 20 30 40 50 60 MAVNGTALLL ANVTYITVEI LIGLCAIVGN VLVIWVVKLN PSLQTTTFYF IVSLALADIA 70 80 90 100 110 120 VGVLVMPLAI VISLGITIQF YNCLFMTCLL LIFTHASIMS LLAIAVDRYL RVKLTVRYRR 130 140 150 160 170 180 VTTQRRIWLA LGLCWLVSFL VGLTPMFGWN MKLTSEHQRN VTFLSCQFSS VMRMDYMVYF 190 200 210 220 230 240 SFFTWILIPL VVMCAIYLDI FYVIRNKLNQ NFSSSKETGA FYGREFKTAK SLFLVLFLFA 250 260 270 280 290 300 FSWLPLSIIN CITYFHGEVP QIILYLGILL SHANSMMNPI VYAYKIKKFK ETYLLIFKTY 310 MICQSSDSLD SSTE

References

[1]

"Canine mast cell adenosine receptors: cloning and expression of the A3 receptor and evidence that degranulation is mediated by the A2B receptor." Auchampach J.A., Jin X., Wan T.C., Caughey G.H., Linden J. Mol. Pharmacol. 52:846-860(1997) [PubMed: 9351976] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U54792 mRNA. Translation: AAB03503.1.
RefSeq	NP_001003178.1.
UniGene	Cfa.3667
3D structure databases
HSSP	HSSP built from PDB template 1MMH based on UniProtKB P29274.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Genome annotation databases
Ensembl	ENSCAFG00000013692. Canis familiaris. [Contig view]
GeneID	403805.
KEGG	cfa:403805.
Phylogenomic databases
HOVERGEN	Q28309.
Family and domain databases
InterPro	IPR000466. Adeno_A3_rcpt. IPR001634. Adenosn_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00555. ADENOSINEA3R. PR00424. ADENOSINER. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProDom	Q28309. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

AA3R_CANFA

Accession

Primary (citable) accession number: Q28309

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	July 22, 2008
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)