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Reviewed, UniProtKB/Swiss-Prot Q2FEI5 (FDHL_STAA3)

Last modified July 22, 2008. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Putative formate dehydrogenase SAUSA300_2258
    EC=1.2.1.2
Gene names
Ordered Locus Names: SAUSA300_2258
OrganismStaphylococcus aureus (strain USA300) [Complete proteome] [HAMAP]
Taxonomic identifier367830 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

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Protein attributes

Sequence length984 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

Formate + NAD(+) = CO(2) + NADH.

Cofactor

Binds 1 2Fe-2S cluster By similarity.

Binds 4 4Fe-4S clusters By similarity.

Molybdenum (molybdopterin) By similarity.

Sequence similarities

In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 2 4Fe-4S ferredoxin-type domains.

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Ontologies

Keywords

   DomainRepeat
   Ligand2Fe-2S
4Fe-4S
Iron
Iron-sulfur
Metal-binding
Molybdenum
NAD
   Molecular functionOxidoreductase
   Technical termComplete proteome

Gene Ontology (GO)

None. [Check GOA]

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 984984Putative formate dehydrogenase SAUSA300_2258

Regions

Domain3 – 79772Fe-2S ferredoxin-type
Domain138 – 165284Fe-4S ferredoxin-type 1
Domain181 – 211314Fe-4S ferredoxin-type 2
Region252 – 984733Formate dehydrogenase

Sites

Metal binding371Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding481Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding511Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding631Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding951Iron-sulfur 2 (4Fe-4S) (via tele nitrogen) By similarity
Metal binding991Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1021Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1091Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1471Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1501Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1531Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1571Iron-sulfur 4 (4Fe-4S) By similarity
Metal binding1901Iron-sulfur 4 (4Fe-4S) By similarity
Metal binding1931Iron-sulfur 4 (4Fe-4S) By similarity
Metal binding1961Iron-sulfur 4 (4Fe-4S) By similarity
Metal binding2001Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding2641Iron-sulfur 5 (4Fe-4S) By similarity
Metal binding2671Iron-sulfur 5 (4Fe-4S) By similarity
Metal binding2711Iron-sulfur 5 (4Fe-4S) By similarity
Metal binding2991Iron-sulfur 5 (4Fe-4S) By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q2FEI5-1 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 9EE43448C906B8DE

FASTA984111,244
        10         20         30         40         50         60 
MQEHLVVTLD GKDYLVEPGT NLLEFIKSQD TFVPSICYNE SMGPIQTCDT CTVEIDGKIE 

        70         80         90        100        110        120 
RSCSTVIDRP MTVNTVNNDV KDAQKEALDR ILEKHMLYCT VCDYNNGDCE IHNTMDAWGL 

       130        140        150        160        170        180 
QHQTYEYKEK PYEKDYGPFY RYDPNQCILC GRCVEACQDI EVNETIRIDW DREHPRVIWD 

       190        200        210        220        230        240 
NDVPINESSC VSCGQCATVC PCNAMMEVNM EGNAGYMTDT EPGSLAAMID LTKKAEPGYG 

       250        260        270        280        290        300 
PLFAISDSEA EMRKERIKKT KTVCTYCGVG CSFEVWTKDR EILKVQPSHD SPANKIATCV 

       310        320        330        340        350        360 
KGKFSWGHIN SDQRLTKPLV RKNGEFHEVE WDEALNVIAD NFTAIKEKHG PDALSFISSS 

       370        380        390        400        410        420 
KATNEESYLM QKLARQVIGT NNVDNCSRYC QAPATKGLFR TVGHGGDSGS IEDLEKAAMS 

       430        440        450        460        470        480 
VLIGTNTAEA HPVIASRMKR AQKLFGQKIH VFDIRKHEMA ERADRFYQPK PGTDLAWLSA 

       490        500        510        520        530        540 
VTKYIIDHDL HDKAFIDEWV DDFDEYYKSL ETFTMAFAEE ATGIPESELI KFAEECAKAE 

       550        560        570        580        590        600 
SVVICWAMGI TQQDIGSDSS TAISNLLLVT GNYRRPGTGA YPLRGHNNVQ GCSDMGSMPD 

       610        620        630        640        650        660 
KITGYQSIEA DDIRAKFEKE YGVKLNPKAG KDNHEMVEGI HDGEVHSLYL YGEDTGIVDS 

       670        680        690        700        710        720 
NINFVQAAFE KLDFMVVQDE FLTFTATYAD VVLPASPSLE KDGTFTNTER RIQRLYQALE 

       730        740        750        760        770        780 
PLGDSKPDWK IFQAIANRLG FDWNYKHPSE IMDEVARLTP LYAGVSYDRL EGFNSLQWPV 

       790        800        810        820        830        840 
QPDGTDEPIL YLEGFNFDNG KAKLFPLSFD NYFKQDEIYD IHVNNGRLLE HFHEGNMTYQ 

       850        860        870        880        890        900 
TPMIKYKVPR AFVEISPELA EDRGIHEGAE VKLISETGEA VLQVHVTDRV KGKEIYIPLN 

       910        920        930        940        950        960 
NDAMENGDLG AINLLTNSDV DQYTDTPSYK RTSCRLEVIT KRGKSPLNPN NFRVNKKRQP 

       970        980 
QYSVQVQKKW ERSDYVFPGN QVDK

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References

[1]"Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus."
Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F.
Lancet 367:731-739(2006) [PubMed: 16517273] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000255 Genomic DNA. Translation: ABD21959.1.
RefSeqYP_494893.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3914062.
GenomeReviewsGene locus SAUSA300_2258 in contig CP000255_GR.
KEGGsaa:SAUSA300_2258.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ2FEI5.

Family and domain databases

InterProIPR001450. 4Fe4S_Fe_S_bd.
IPR009010. Asp_de-COase-like_fold.
IPR001041. Ferredoxin.
IPR006478. Formate_DHase_asu.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_Fe4S4.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR006657. MPT_dinuc_bd.
[Graphical view]
Gene3DG3DSA:2.40.40.20. Asp_decarboxylase-like_fold. 1 hit.
PfamPF00111. Fer2. 1 hit.
PF00037. Fer4. 2 hits.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
[Graphical view]
PRINTSPR00353. 4FE4SFRDOXIN.
TIGRFAMsTIGR01591. Fdh-alpha. 1 hit.
PROSITEPS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00490. MOLYBDOPTERIN_PROK_2. False negative.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
[Graphical view]
ProDomQ2FEI5.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameFDHL_STAA3
AccessionPrimary (citable) accession number: Q2FEI5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 21, 2006
Last modified: July 22, 2008
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents