Reviewed, UniProtKB/Swiss-Prot Q2M3C6 (CO027_HUMAN)

Names and origin

Protein names

Recommended name:
    Transmembrane protein C15orf27

Gene names

Name:

C15orf27

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	531 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane proteinPotential.
Sequence caution	BAC04562.1 sequence differs from that shown. Reason: Frameshift at positions 13 and 93.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Transmembrane
PTM	Glycoprotein
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q2M3C6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Notes: Gene prediction based on EST data.

Isoform 2 (identifier: Q2M3C6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     93-128: Missing.

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 531	531	Transmembrane protein C15orf27
Regions
	Transmembrane	103 – 123	21	Potential
	Transmembrane	130 – 150	21	Potential
	Transmembrane	170 – 190	21	Potential
	Coiled coil	226 – 278	53	Potential
Amino acid modifications
	Glycosylation	8	1	N-linked (GlcNAc...) Potential
	Glycosylation	363	1	N-linked (GlcNAc...) Potential
	Glycosylation	380	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	93 – 128	36	Missing in isoform 2.
	Natural variant	391	1	R → H: dbSNP rs937732.
	Natural variant	427	1	P → L: dbSNP rs937733.

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 9, 2007. Version 2. Checksum: 4C4151B0B3CD4FB2	FASTA	531	58,444
	10 20 30 40 50 60 MAVAPSFNMT NPQPAIEGGI SEVEIISQQV DEETKSIAPV QLVNFAYRDL PLAAVDLSTA 70 80 90 100 110 120 GSQLLSNLDE DYQREGSNWL KPCCGKRAAV WQVFLLSASL NSFLVACVIL VVILLTLELL 130 140 150 160 170 180 IDIKLLQFSS AFQFAGVIHW ISLVILSVFF SETVLRIVVL GIWDYIENKI EVFDGAVIIL 190 200 210 220 230 240 SLAPMVASTV ANGPRSPWDA ISLIIMLRIW RVKRVIDAYV LPVKLEMEMV IQQYEKAKVI 250 260 270 280 290 300 QDEQLERLTQ ICQEQGFEIR QLRAHLAQQD LDLAAEREAA LQAPHVLSQP RSRFKVLEAG 310 320 330 340 350 360 TWDEETAAES VVEELQPSQE ATMKDDMNSY ISQYYNGPSS DSGVPEPAVC MVTTAAIDIH 370 380 390 400 410 420 QPNISSDLFS LDMPLKLGGN GTSATSESAS RSSVTRAQSD SSQTLGSSMD CSTAREEPSS 430 440 450 460 470 480 EPGPSPPPLP SQQQVEEATV QDLLSSLSED PCPSQKALDP APLARPSPAG SAQTSPELEH 490 500 510 520 530 RVSLFNQKNQ EGFTVFQIRP VIHFQPTVPM LEDKFRSLES KEQKLHRVPE A
	Isoform 2 [UniParc]. Checksum: 02D010F2CDE4D852		495	54,474
	10 20 30 40 50 60 MAVAPSFNMT NPQPAIEGGI SEVEIISQQV DEETKSIAPV QLVNFAYRDL PLAAVDLSTA 70 80 90 100 110 120 GSQLLSNLDE DYQREGSNWL KPCCGKRAAV WQSSAFQFAG VIHWISLVIL SVFFSETVLR 130 140 150 160 170 180 IVVLGIWDYI ENKIEVFDGA VIILSLAPMV ASTVANGPRS PWDAISLIIM LRIWRVKRVI 190 200 210 220 230 240 DAYVLPVKLE MEMVIQQYEK AKVIQDEQLE RLTQICQEQG FEIRQLRAHL AQQDLDLAAE 250 260 270 280 290 300 REAALQAPHV LSQPRSRFKV LEAGTWDEET AAESVVEELQ PSQEATMKDD MNSYISQYYN 310 320 330 340 350 360 GPSSDSGVPE PAVCMVTTAA IDIHQPNISS DLFSLDMPLK LGGNGTSATS ESASRSSVTR 370 380 390 400 410 420 AQSDSSQTLG SSMDCSTARE EPSSEPGPSP PPLPSQQQVE EATVQDLLSS LSEDPCPSQK 430 440 450 460 470 480 ALDPAPLARP SPAGSAQTSP ELEHRVSLFN QKNQEGFTVF QIRPVIHFQP TVPMLEDKFR 490 SLESKEQKLH RVPEA

References

[1]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed: 16572171] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS HIS-391 AND LEU-427. Tissue: Fetal brain and Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 174-531.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC091100 Genomic DNA. No translation available. AK058126 mRNA. Translation: BAB71676.1. Different initiation. AK095509 mRNA. Translation: BAC04562.1. Frameshift. BC104953 mRNA. Translation: AAI04954.1. Different initiation. BC104955 mRNA. Translation: AAI04956.1. Different initiation.
RefSeq	NP_689548.2.
UniGene	Hs.661411
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q2M3C6.
Genome annotation databases
Ensembl	ENSG00000169758. Homo sapiens. [Contig view]
GeneID	123591.
KEGG	hsa:123591.
Organism-specific databases
HGNC	HGNC:26763. C15orf27.
PharmGKB	PA134968419.
GenAtlas	Search...
GeneCards	Search...
GeneLynx	Search...
Phylogenomic databases
HOGENOM	Q2M3C6.
HOVERGEN	Q2M3C6.
Gene expression databases
ArrayExpress	Q2M3C6.
CleanEx	HS_C15orf27.
GermOnline	ENSG00000169758. Homo sapiens.
Family and domain databases
InterPro	IPR005821. Ion_trans. [Graphical view]
Pfam	PF00520. Ion_trans. 1 hit. [Graphical view]
ProDom	Q2M3C6. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

CO027_HUMAN

Accession

Primary (citable) accession number: Q2M3C6
Secondary accession number(s): Q8N993, Q96LL5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	January 9, 2007
Last modified:	July 22, 2008
This is version 23 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)