Reviewed, UniProtKB/Swiss-Prot Q2MH31 (CI024_MOUSE)

Names and origin

Protein names

Recommended name:
    Uncharacterized protein C9orf24 homolog
Alternative name(s):
    Spermatid-specific manchette-related protein 1

Gene names

Name:

Smrp1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q2MH31-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q2MH31-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: Missing.

Notes: No experimental confirmation available.

Isoform 3 (identifier: Q2MH31-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: Missing.
     233-260: ECVALRSPARNAMCCYNSPAIILPVSQP → VRSVSPFGHR...VSETCPVYPS

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 260	260	Uncharacterized protein C9orf24 homolog
Natural variations
	Alternative sequence	1 – 134	134	Missing in isoform 2 and isoform 3.
	Alternative sequence	233 – 260	28	ECVAL…PVSQP → VRSVSPFGHRPGMQCAVTTP PPSFYPYPNLRWDTSHFKKT GGSQRNNYVVHPEFVSETCP VYPS in isoform 3.

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 21, 2006. Version 1. Checksum: 3BAE6877F4490A0E	FASTA	260	29,939
	10 20 30 40 50 60 MFLFSRKTKT PISTYSDSYR APTSIKEVYK DPPLWAWEAN KFVTPGLTQT MHRHVDPEAL 70 80 90 100 110 120 QKMTKCAAQD YTYKSSISGH PYLPEKYWLS PDEEDKCCPS YLDNDRYNTW KTSPCSNYWN 130 140 150 160 170 180 KYTGCLPRLS KDTGMESVRG MPLEYPPKQE RLNAYEREVV VNMLNSLSRN RTLPQIVPRC 190 200 210 220 230 240 GCVDPLPGRL PYQGYESPCS GRHYCLRGMD YCTTREPSTE RRLRPLCSQQ PTECVALRSP 250 260 ARNAMCCYNS PAIILPVSQP
	Isoform 2 [UniParc]. Checksum: 820295EE000B1F69		126	14,317
	10 20 30 40 50 60 MESVRGMPLE YPPKQERLNA YEREVVVNML NSLSRNRTLP QIVPRCGCVD PLPGRLPYQG 70 80 90 100 110 120 YESPCSGRHY CLRGMDYCTT REPSTERRLR PLCSQQPTEC VALRSPARNA MCCYNSPAII LPVSQP
	Isoform 3 [UniParc]. Checksum: 88502950CD0733A6		162	18,552
	10 20 30 40 50 60 MESVRGMPLE YPPKQERLNA YEREVVVNML NSLSRNRTLP QIVPRCGCVD PLPGRLPYQG 70 80 90 100 110 120 YESPCSGRHY CLRGMDYCTT REPSTERRLR PLCSQQPTVR SVSPFGHRPG MQCAVTTPPP 130 140 150 160 SFYPYPNLRW DTSHFKKTGG SQRNNYVVHP EFVSETCPVY PS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of a haploid germ cell specific gene mouse smrp1 encoding a novel manchette protein." Matsuoka Y., Miyagawa Y., Kitamura K., Iguchi N., Maekawa M., Takahashi T., Tsujimura A., Matsumiya K., Okuyama A., Nishimune Y., Tanaka H. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Testis.
[2]	"Mouse ciliated bronchial epithelium 1 (mCBE1)." Yoshisue H. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3). Strain: MF1.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: C57BL/6J. Tissue: Embryo.
[4]	The mouse genome sequencing consortium Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB231294 mRNA. Translation: BAE78528.1. DQ873295 mRNA. Translation: ABI35956.1. DQ873296 mRNA. Translation: ABI35957.1. AK003742 mRNA. Translation: BAB22974.1. AL831723 Genomic DNA. Translation: CAM13279.1.
RefSeq	NP_001041470.1. NP_082900.1.
UniGene	Mm.45614
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000028441. Mus musculus. [Contig view]
GeneID	73721.
KEGG	mmu:73721.
Organism-specific databases
MGI	MGI:1920971. 1110017D15Rik.
Phylogenomic databases
HOGENOM	Q2MH31.
HOVERGEN	Q2MH31.
Gene expression databases
ArrayExpress	Q2MH31.
CleanEx	MM_1110017D15RIK.
Family and domain databases
ProDom	Q2MH31. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

CI024_MOUSE

Accession

Primary (citable) accession number: Q2MH31
Secondary accession number(s): Q0GC36, Q9D1B3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	February 21, 2006
Last modified:	July 22, 2008
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)