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Reviewed, UniProtKB/Swiss-Prot Q32ZE2 (AA2BR_RABIT)

Last modified September 2, 2008. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Adenosine receptor A2b
Gene names
Name: ADORA2B
OrganismOryctolagus cuniculus (Rabbit)
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

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Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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Ontologies

Keywords

   Cellular componentCell membrane
Membrane
   DomainTransmembrane
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
Lipoprotein
Palmitate

Gene Ontology (GO)

None. [Check GOA]

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 332332Adenosine receptor A2b

Regions

Topological domain1 – 88Extracellular Potential
Transmembrane9 – 31231 Potential
Topological domain32 – 4413Cytoplasmic Potential
Transmembrane45 – 67232 Potential
Topological domain68 – 7811Extracellular Potential
Transmembrane79 – 101233 Potential
Topological domain102 – 12120Cytoplasmic Potential
Transmembrane122 – 144234 Potential
Topological domain145 – 17834Extracellular Potential
Transmembrane179 – 203255 Potential
Topological domain204 – 23532Cytoplasmic Potential
Transmembrane236 – 259246 Potential
Topological domain260 – 2678Extracellular Potential
Transmembrane268 – 291247 Potential
Topological domain292 – 33241Cytoplasmic Potential

Amino acid modifications

Lipidation3111S-palmitoyl cysteine Potential
Glycosylation1531N-linked (GlcNAc...) Potential
Glycosylation1631N-linked (GlcNAc...) Potential
Disulfide bond78 ↔ 171 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q32ZE2-1 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: EBE31450932589B3

FASTA33236,251
        10         20         30         40         50         60 
MQLETQDALY VALELAIAAL SVAGNVLVCA AVGTSSALQT PTNYFLVSLA AADVAVGLFA 

        70         80         90        100        110        120 
IPFAITISLG FCTDFHSCLF LACFVLVLTQ SSIFSLLAVA VDRYLAILVP LRYKSLVTGT 

       130        140        150        160        170        180 
RARGVIAVLW VLAFGIGLTP FLGWNSKDSA TANCTEPRDG TTNESCCLVK CLFENVVPMS 

       190        200        210        220        230        240 
YMVYFNFFGC VLPPLLIMLA IYIKIFLVAC RQLQRTELMD HSRTTLQREI HAAKSLAMIV 

       250        260        270        280        290        300 
GIFALCWLPV HAINCVTLFQ PAQAKDKPKW AMNTAILLSH ANSVVNPIVY AYRNRDFRET 

       310        320        330 
FHKIISRYVL CQTDVKSGNG QSGAQPVLSM GL

« Hide

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References

[1]"Analysis of recombinant A2B adenosine receptors from multiple species: identification of a potential non-functional splice variant."
Auchampach J.A., Wan T.C., Kreckler L.M.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

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Cross-references

Sequence databases

AY630339 mRNA. Translation: AAV31919.1.
RefSeqNP_001075644.1.
UniGeneOcu.3348

3D structure databases

ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Genome annotation databases

GeneID100008951.

Phylogenomic databases

HOVERGENQ32ZE2.

Family and domain databases

InterProIPR001435. Adeno_A2B_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00554. ADENOSINA2BR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProDomQ32ZE2.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameAA2BR_RABIT
AccessionPrimary (citable) accession number: Q32ZE2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 6, 2005
Last modified: September 2, 2008
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents