Reviewed, UniProtKB/Swiss-Prot Q39090 (UFO_ARATH)

Names and origin

Protein names

Recommended name:
    Protein UNUSUAL FLORAL ORGANS
Alternative name(s):
    F-box only protein 1
      Short name=AtFBX1

Gene names

Name:	UFO
Synonyms:	FBX1
Ordered Locus Names:	At1g30950
ORF Names:	F17F8.16

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Considered as a meristem identity factor required for normal growth of the young floral meristem. Acts together with LEAFY to positively regulate the B class floral homeotic genes APETALA3 and PISTILLATA. In this way, operates as a region-specific regulator for petal and stamen development. Alternatively, may play a role as a negative regulator of the C class floral homeotic genes. Interacts together with the SKP1-like protein ASK1 to form a ubiquitin E3 ligase complex and could indirectly promote the ubiquitination and degradation of specific proteins controlling the floral primordia development like repressors of B class floral homeotic genes.
Subunit structure	Part of a putative SCF (SKP1/Cullin/F-box) ubiquitin ligase complex. Interacts with SKP1.
Subcellular location	NucleusProbable.
Developmental stage	Detected early throughout the shoot apical meristem, but not in the emerging leaf primordia. Restricted later to the junction between sepal and petal primordia.
Miscellaneous	Mutations in the UFO gene result in the formation of unusual floral organs.
Sequence similarities	Contains 1 F-box domain.

Ontologies

Keywords
Biological process	Differentiation Flowering Transcription Transcription regulation Ubl conjugation pathway
Cellular component	Nucleus
Molecular function	Activator Developmental protein
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
AT4g34210	O49484	2	EBI-590758,EBI-401185
LFY	Q00958	3	EBI-590758,EBI-1644366
SKP1A	Q39255	4	EBI-590758,EBI-532357
SKP1B	Q9FHW7	2	EBI-590758,EBI-604076

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 442	442	Protein UNUSUAL FLORAL ORGANS
Regions
	Domain	44 – 90	47	F-box
Experimental info
	Sequence conflict	44	1	G → C in CAA61508. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q39090-1 [UniParc]. Last modified May 9, 2003. Version 2. Checksum: 6E5C38B0F92AE8B7	FASTA	442	49,047
	10 20 30 40 50 60 MDSTVFINNP SLTLPFSYTF TSSSNSSTTT STTTDSSSGQ WMDGRIWSKL PPPLLDRVIA 70 80 90 100 110 120 FLPPPAFFRT RCVCKRFYSL LFSNTFLETY LQLLPLRHNC FLFFKHKTLK SYIYKRGGTN 130 140 150 160 170 180 DDDSNKAEGF LFDPNEIRWY RLSFAYIPSG FYPSGSSGGL VSWVSEEAGL KTILLCNPLV 190 200 210 220 230 240 GSVSQLPPIS RPRLFPSIGL SVTPTSIDVT VAGDDLISPY AVKNLSSESF HVDAGGFFSL 250 260 270 280 290 300 WAMTSSLPRL CSLESGKMVY VQGKFYCMNY SPFSVLSYEV TGNRWIKIQA PMRRFLRSPS 310 320 330 340 350 360 LLESKGRLIL VAAVEKSKLN VPKSLRLWSL QQDNATWVEI ERMPQPLYTQ FAAEEGGKGF 370 380 390 400 410 420 ECVGNQEFVM IVLRGTSLQL LFDIVRKSWL WVPPCPYSGS GGGSSGGGSD GEVLQGFAYD 430 440 PVLTTPVVSL LDQLTLPFPG VC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Parallels between UNUSUAL FLORAL ORGANS and FIMBRIATA, genes controlling flower development in Arabidopsis and Antirrhinum." Ingram G.C., Goodrich J., Wilkinson M.D., Simon R., Haughn G.W., Coen E.S. Plant Cell 7:1501-1510(1995) [PubMed: 8589630] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION. Strain: cv. Landsberg erecta.
[2]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed: 11130712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W., Redman J.C., Wu H.C., Utterback T., Town C.D. Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"The Arabidopsis homeotic genes APETALA3 and PISTILLATA are sufficient to provide the B class organ identity function." Krizek B.A., Meyerowitz E.M. Development 122:11-22(1996) [PubMed: 8565821] [Abstract] Cited for: FUNCTION.
[5]	"A LEAFY co-regulator encoded by UNUSUAL FLORAL ORGANS." Lee I., Wolfe D.S., Nilsson O., Weigel D. Curr. Biol. 7:95-104(1997) [PubMed: 9016705] [Abstract] Cited for: FUNCTION, DEVELOPMENTAL STAGE.
[6]	"The UNUSUAL FLORAL ORGANS gene of Arabidopsis thaliana is an F-box protein required for normal patterning and growth in the floral meristem." Samach A., Klenz J.E., Kohalmi S.E., Risseeuw E., Haughn G.W., Crosby W.L. Plant J. 20:433-445(1999) [PubMed: 10607296] [Abstract] Cited for: FUNCTION.
[7]	"F-box proteins in Arabidopsis." Xiao W., Jang J.-C. Trends Plant Sci. 5:454-457(2000) [PubMed: 11077244] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
[8]	"The ASK1 gene regulates B function gene expression in cooperation with UFO and LEAFY in Arabidopsis." Zhao D., Yu Q., Chen M., Ma H. Development 128:2735-2746(2001) [PubMed: 11526079] [Abstract] Cited for: SUBUNIT.
[9]	"The F-box-containing protein UFO and AGAMOUS participate in antagonistic pathways governing early petal development in Arabidopsis." Durfee T., Roe J.L., Sessions R.A., Inouye C., Serikawa K., Feldmann K.A., Weigel D., Zambryski P.C. Proc. Natl. Acad. Sci. U.S.A. 100:8571-8576(2003) [PubMed: 12826617] [Abstract] Cited for: INTERACTION WITH SKP1, DOMAIN.

Web resources

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Cross-references

Sequence databases
EMBLGenBankDDBJ	X89224 Genomic DNA. Translation: CAA61508.1. AC000107 Genomic DNA. Translation: AAF98199.1. DQ056469 mRNA. Translation: AAY78626.1.
PIR	S57710.
RefSeq	NP_564368.1.
UniGene	At.51845
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q39090.
Genome annotation databases
GeneID	839982.
GenomeReviews	Gene locus AT1G30950 in contig CT485782_GR.
KEGG	ath:AT1G30950.
NMPDR	fig|3702.1.peg.3439.
Organism-specific databases
TAIR	At1g30950.
Gene expression databases
ArrayExpress	Q39090.
GermOnline	AT1G30950. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR001810. F-box. [Graphical view]
Pfam	PF00646. F-box. 1 hit. [Graphical view]
SMART	SM00256. FBOX. 1 hit. [Graphical view]
PROSITE	PS50181. FBOX. 1 hit. [Graphical view]
ProDom	Q39090. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

UFO_ARATH

Accession

Primary (citable) accession number: Q39090
Secondary accession number(s): Q4PT17, Q9FYI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 9, 2003
Last sequence update:	May 9, 2003
Last modified:	July 22, 2008
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)