Reviewed, UniProtKB/Swiss-Prot Q3I5F7 (ACOT6_HUMAN)

Names and origin

Protein names

Recommended name:
    Putative acyl-coenzyme A thioesterase 6
      Short name=Acyl-CoA thioesterase 6
    EC=3.1.2.-

Gene names

Name:

ACOT6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Unknown.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the C/M/P thioester hydrolase family.
Caution	May lack catalytic activity, even though the active site residues are conserved.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase Serine esterase
Gene Ontology (GO)
Cellular component	cytosol Ref.1 Inferred from direct assay. Source: HGNC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 207	207	Putative acyl-coenzyme A thioesterase 6
Sites
	Active site	18	1	Charge relay system Potential
	Active site	112	1	Charge relay system Potential
	Active site	146	1	Charge relay system Potential

Sequences

	Sequence		Length	Mass (Da)
	Q3I5F7-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: B77AB1DC5760D306	FASTA	207	22,991
	10 20 30 40 50 60 MLQHPKVKGP SIALLGFSKG GDLCLSMASF LKGITATVLI NACVANTVAP LHYKDMIIPK 70 80 90 100 110 120 LVDDLGKVKI TKSGFLTFMD TWSNPLEEHN HQSLVPLEKA QVPFLFIVGM DDQSWKSEFY 130 140 150 160 170 180 AQIASERLQA HGKERPQIIC YPETGHCIDP PYFPPSRASV HAVLGEAIFY GGEPKAHSKA 190 200 QVDAWQQIQT FFHKHLNGKK SVKHSKI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs." Hunt M.C., Rautanen A., Westin M.A.K., Svensson L.T., Alexson S.E.H. FASEB J. 20:1855-1864(2006) [PubMed: 16940157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PROBABLE ABSENCE OF CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ082756 mRNA. Translation: AAZ31238.1. BC126378 mRNA. Translation: AAI26379.1. BC126380 mRNA. Translation: AAI26381.1.
RefSeq	NP_001032239.1.
UniGene	Hs.122038
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000205669. Homo sapiens. [Contig view]
GeneID	641372.
KEGG	hsa:641372.
Organism-specific databases
HGNC	HGNC:33159. ACOT6.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q3I5F7.
HOVERGEN	Q3I5F7.
Gene expression databases
ArrayExpress	Q3I5F7.
CleanEx	HS_ACOT6.
Family and domain databases
InterPro	IPR014940. BAAT_C. [Graphical view]
Pfam	PF08840. BAAT_C. 1 hit. [Graphical view]
ProDom	Q3I5F7. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ACOT6_HUMAN

Accession

Primary (citable) accession number: Q3I5F7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	November 8, 2005
Last modified:	July 22, 2008
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)