Reviewed, UniProtKB/Swiss-Prot Q3SXY8 (AR13B_HUMAN)

Names and origin

Protein names

Recommended name:
    ADP-ribosylation factor-like protein 13B
Alternative name(s):
    ADP-ribosylation factor-like protein 2-like 1
      Short name=ARL2-like protein 1

Gene names

Name:	ARL13B
Synonyms:	ARL2L1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the small GTPase superfamily. Arf family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Ligand	GTP-binding Nucleotide-binding
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q3SXY8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q3SXY8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     21-127: Missing.

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 428	428	ADP-ribosylation factor-like protein 13B
Regions
	Nucleotide binding	28 – 35	8	GTP By similarity
	Nucleotide binding	71 – 75	5	GTP By similarity
	Nucleotide binding	130 – 133	4	GTP By similarity
	Coiled coil	192 – 245	54	Potential
	Compositional bias	369 – 419	51	Pro-rich
Natural variations
	Alternative sequence	21 – 127	107	Missing in isoform 2.

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 002B38A38D1F7BDD	FASTA	428	48,643
	10 20 30 40 50 60 MFSLMASCCG WFKRWREPVR KVTLLMVGLD NAGKTATAKG IQGEYPEDVA PTVGFSKINL 70 80 90 100 110 120 RQGKFEVTIF DLGGGIRIRG IWKNYYAESY GVIFVVDSSD EERMEETKEA MSEMLRHPRI 130 140 150 160 170 180 SGKPILVLAN KQDKEGALGE ADVIECLSLE KLVNEHKCLC QIEPCSAISG YGKKIDKSIK 190 200 210 220 230 240 KGLYWLLHVI ARDFDALNER IQKETTEQRA LEEQEKQERA ERVRKLREER KQNEQEQAEL 250 260 270 280 290 300 DGTSGLAELD PEPTNPFQPI ASVIIENEGK LEREKKNQKM EKDSDGCHLK HKMEHEQIET 310 320 330 340 350 360 QGQVNHNGQK NNEFGLVENY KEALTQQLKN EDETDRPSLE SANGKKKTKK LRMKRNHRVE 370 380 390 400 410 420 PLNIDDCAPE SPTPPPPPPP VGWGTPKVTR LPKLEPLGET HHNDFYRKPL PPLAVPQRPN SDAHDVIS
	Isoform 2 [UniParc]. Checksum: D4D82D271E9E7F1E		321	36,795
	10 20 30 40 50 60 MFSLMASCCG WFKRWREPVR LANKQDKEGA LGEADVIECL SLEKLVNEHK CLCQIEPCSA 70 80 90 100 110 120 ISGYGKKIDK SIKKGLYWLL HVIARDFDAL NERIQKETTE QRALEEQEKQ ERAERVRKLR 130 140 150 160 170 180 EERKQNEQEQ AELDGTSGLA ELDPEPTNPF QPIASVIIEN EGKLEREKKN QKMEKDSDGC 190 200 210 220 230 240 HLKHKMEHEQ IETQGQVNHN GQKNNEFGLV ENYKEALTQQ LKNEDETDRP SLESANGKKK 250 260 270 280 290 300 TKKLRMKRNH RVEPLNIDDC APESPTPPPP PPPVGWGTPK VTRLPKLEPL GETHHNDFYR 310 320 KPLPPLAVPQ RPNSDAHDVI S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain.
[2]	"Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome." Fan Y., Esmail M.A., Ansley S.J., Blacque O.E., Boroevich K., Ross A.J., Moore S.J., Badano J.L., May-Simera H., Compton D.S., Green J.S., Lewis R.A., van Haelst M.M., Parfrey P.S., Baillie D.L., Beales P.L., Katsanis N., Davidson W.S., Leroux M.R. Nat. Genet. 36:989-993(2004) [PubMed: 15314642] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC094725 mRNA. Translation: AAH94725.1. BC104035 mRNA. Translation: AAI04036.1. BC104036 mRNA. Translation: AAI04037.1.
RefSeq	NP_878899.1.
UniGene	Hs.533086
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000169379. Homo sapiens. [Contig view]
GeneID	200894.
Organism-specific databases
HGNC	HGNC:25419. ARL13B.
MIM	608922. gene.
PharmGKB	PA134975272.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q3SXY8.
Gene expression databases
ArrayExpress	Q3SXY8.
CleanEx	HS_ARL13B.
GermOnline	ENSG00000169379. Homo sapiens.
Family and domain databases
InterPro	IPR006689. ARF/SAR. IPR005225. Small_GTP_bd. [Graphical view]
PANTHER	PTHR11711. ARF/SAR. 1 hit.
Pfam	PF00025. Arf. 1 hit. [Graphical view]
PRINTS	PR00328. SAR1GTPBP.
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
ProDom	Q3SXY8. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

AR13B_HUMAN

Accession

Primary (citable) accession number: Q3SXY8
Secondary accession number(s): Q504W8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	October 11, 2005
Last modified:	July 22, 2008
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)