Reviewed, UniProtKB/Swiss-Prot Q3TNH5 (F172A_MOUSE)

Names and origin

Protein names

Recommended name:
    UPF0528 protein FAM172A

Gene names

Name:

Fam172a

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	417 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	SecretedPotential.
Sequence similarities	Belongs to the UPF0528 family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Signal
PTM	Glycoprotein
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q3TNH5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q3TNH5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.

Notes: No experimental confirmation available.

Isoform 3 (identifier: Q3TNH5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.
     126-189: Missing.

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 417	399	UPF0528 protein FAM172A
Regions
	Motif	414 – 417	4	Prevents secretion from ER Potential
Amino acid modifications
	Glycosylation	26	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 138	138	Missing in isoform 2.
	Alternative sequence	1 – 46	46	Missing in isoform 3.
	Alternative sequence	126 – 189	64	Missing in isoform 3.

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: 8FBE7D0873DA8109	FASTA	417	48,072
	10 20 30 40 50 60 MSISLSSLIF LPIWINMAQM QQGGSNETEQ TAALKDLLSR IDLDELMKKD EPPFDFPDTL 70 80 90 100 110 120 EGFEYAFNEK GQLRHIKTGE PFVFNYREDL HRWNQKRYEA LGEIITRYVY ELLESDCNLK 130 140 150 160 170 180 KISIPVDATE SEPKSFIFMS EDALTNPQKL MVLIHGSGVV RAGQWARRLI INEDLDSGTQ 190 200 210 220 230 240 IPFIKRAMDE GYGVIVLNPN ENYIEVEKQK MHKQSSSSDG TDEPAGKRER RDKVSKETKK 250 260 270 280 290 300 RRDFYEKYRN PQKEKEMMQL FIRENGSPEE HAVYVWDHFI AQAAAENVFF VAHSYGGLAF 310 320 330 340 350 360 VELMIQREAD VKSKVTAVAL TDSVHNVWHQ EAGKTIREWM RENCCNWVSS SEPLDTSVES 370 380 390 400 410 MLPDCPRVSA GTDRHELTSW KSFPSIFKFF AEASEAKSSS QKPALTRRSH RIKHEEL
	Isoform 2 [UniParc]. Checksum: 0AB4FE1707A3D22B		279	31,975
	10 20 30 40 50 60 MSEDALTNPQ KLMVLIHGSG VVRAGQWARR LIINEDLDSG TQIPFIKRAM DEGYGVIVLN 70 80 90 100 110 120 PNENYIEVEK QKMHKQSSSS DGTDEPAGKR ERRDKVSKET KKRRDFYEKY RNPQKEKEMM 130 140 150 160 170 180 QLFIRENGSP EEHAVYVWDH FIAQAAAENV FFVAHSYGGL AFVELMIQRE ADVKSKVTAV 190 200 210 220 230 240 ALTDSVHNVW HQEAGKTIRE WMRENCCNWV SSSEPLDTSV ESMLPDCPRV SAGTDRHELT 250 260 270 SWKSFPSIFK FFAEASEAKS SSQKPALTRR SHRIKHEEL
	Isoform 3 [UniParc]. Checksum: 605B0CD185BBD4B9		307	35,840
	10 20 30 40 50 60 MKKDEPPFDF PDTLEGFEYA FNEKGQLRHI KTGEPFVFNY REDLHRWNQK RYEALGEIIT 70 80 90 100 110 120 RYVYELLESD CNLKKISIPE GYGVIVLNPN ENYIEVEKQK MHKQSSSSDG TDEPAGKRER 130 140 150 160 170 180 RDKVSKETKK RRDFYEKYRN PQKEKEMMQL FIRENGSPEE HAVYVWDHFI AQAAAENVFF 190 200 210 220 230 240 VAHSYGGLAF VELMIQREAD VKSKVTAVAL TDSVHNVWHQ EAGKTIREWM RENCCNWVSS 250 260 270 280 290 300 SEPLDTSVES MLPDCPRVSA GTDRHELTSW KSFPSIFKFF AEASEAKSSS QKPALTRRSH RIKHEEL

References

[1]

"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Strain: C57BL/6J. Tissue: Mammary gland and Spleen.

[2]

The mouse genome sequencing consortium Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK165273 mRNA. Translation: BAE38114.1. AK166285 mRNA. Translation: BAE38682.1. AC167171 Genomic DNA. No translation available. AC154584 Genomic DNA. No translation available. AC154548 Genomic DNA. No translation available. CT025642 Genomic DNA. No translation available.
UniGene	Mm.343005
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000064138. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:1915925. 1110033M05Rik.
Phylogenomic databases
HOVERGEN	Q3TNH5.
Gene expression databases
ArrayExpress	Q3TNH5.
CleanEx	MM_1110033M05RIK.
Family and domain databases
InterPro	IPR000886. ER_targeting_sequence. [Graphical view]
PROSITE	PS00014. ER_TARGET. 1 hit. [Graphical view]
ProDom	Q3TNH5. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

F172A_MOUSE

Accession

Primary (citable) accession number: Q3TNH5
Secondary accession number(s): Q3TLW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	September 2, 2008
This is version 24 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)