Reviewed, UniProtKB/Swiss-Prot Q3U6N9 (CH033_MOUSE)

Names and origin

Protein names	Recommended name:     UPF0488 protein C8orf33 homolog
Organism	Mus musculus (Mouse)
Taxonomic identifier	10090 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the UPF0488 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q3U6N9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q3U6N9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.
     129-129: Missing.

Notes: No experimental confirmation available.

Isoform 3 (identifier: Q3U6N9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 222	222	UPF0488 protein C8orf33 homolog
Regions
	Compositional bias	64 – 69	6	Poly-Lys
Natural variations
	Alternative sequence	1 – 62	62	Missing in isoform 2 and isoform 3.
	Alternative sequence	129	1	Missing in isoform 2.

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 53D7B2DE0876A60C	FASTA	222	24,465
	10 20 30 40 50 60 MAEPGRPARE APAASSRKTH RAPRRPRPSR SASGASEPPL RSSVQPACDS AAGTHPVGNT 70 80 90 100 110 120 VAMKQKKKKT PNRVSGTNGS EKPSEKPAPD EAPPSAEAQA EQLARELAWC VEQLELGLKT 130 140 150 160 170 180 QRPTPKQKEQ AVGAIRTLRS EKTPLPRKRQ LMRSLFGDYR AQMDAEWREA LRALKAATHS 190 200 210 220 AQVQLVSEAT RKKSGRVCRP RPAERAKTTP DLTSEEFRFN FF
	Isoform 2 [UniParc]. Checksum: C914FAABC27D338A		159	17,999
	10 20 30 40 50 60 MKQKKKKTPN RVSGTNGSEK PSEKPAPDEA PPSAEAQAEQ LARELAWCVE QLELGLKTQR 70 80 90 100 110 120 PTPKQKQAVG AIRTLRSEKT PLPRKRQLMR SLFGDYRAQM DAEWREALRA LKAATHSAQV 130 140 150 QLVSEATRKK SGRVCRPRPA ERAKTTPDLT SEEFRFNFF
	Isoform 3 [UniParc]. Checksum: 67B00E6D6E5DB8C4		160	18,128
	10 20 30 40 50 60 MKQKKKKTPN RVSGTNGSEK PSEKPAPDEA PPSAEAQAEQ LARELAWCVE QLELGLKTQR 70 80 90 100 110 120 PTPKQKEQAV GAIRTLRSEK TPLPRKRQLM RSLFGDYRAQ MDAEWREALR ALKAATHSAQ 130 140 150 160 VQLVSEATRK KSGRVCRPRP AERAKTTPDL TSEEFRFNFF

References

[1]

"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). Strain: C57BL/6J. Tissue: Bone marrow, Embryo and Head.

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Strain: Czech II. Tissue: Mammary tumor.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK004154 mRNA. Translation: BAB23195.1. AK141496 mRNA. Translation: BAE24703.1. AK153059 mRNA. Translation: BAE31685.1. AK160695 mRNA. Translation: BAE35959.1. BC038324 mRNA. Translation: AAH38324.1. BC091734 mRNA. Translation: AAH91734.1.
RefSeq	NP_473440.1.
UniGene	Mm.322968 Mm.440229
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000063236. Mus musculus. [Contig view]
GeneID	117171.
KEGG	mmu:117171.
Organism-specific databases
MGI	MGI:2152337. 1110038F14Rik.
Phylogenomic databases
HOGENOM	Q3U6N9.
HOVERGEN	Q3U6N9.
Gene expression databases
ArrayExpress	Q3U6N9.
CleanEx	MM_1110038F14RIK.
Family and domain databases
ProDom	Q3U6N9. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

CH033_MOUSE

Accession

Primary (citable) accession number: Q3U6N9
Secondary accession number(s): Q3URI5, Q9D0Z5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	October 11, 2005
Last modified:	July 22, 2008
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)