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Reviewed, UniProtKB/Swiss-Prot Q49ZN0 (FDHL_STAS1)

Last modified September 2, 2008. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Putative formate dehydrogenase SSP0601
    EC=1.2.1.2
Gene names
Ordered Locus Names: SSP0601
OrganismStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]
Taxonomic identifier342451 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

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Protein attributes

Sequence length984 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

Formate + NAD(+) = CO(2) + NADH.

Cofactor

Binds 1 2Fe-2S cluster By similarity.

Binds 4 4Fe-4S clusters By similarity.

Molybdenum (molybdopterin) By similarity.

Sequence similarities

In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 2 4Fe-4S ferredoxin-type domains.

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Ontologies

Keywords

   DomainRepeat
   Ligand2Fe-2S
4Fe-4S
Iron
Iron-sulfur
Metal-binding
Molybdenum
NAD
   Molecular functionOxidoreductase
   Technical termComplete proteome

Gene Ontology (GO)

None. [Check GOA]

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 984984Putative formate dehydrogenase SSP0601

Regions

Domain3 – 79772Fe-2S ferredoxin-type
Domain138 – 167304Fe-4S ferredoxin-type 1
Domain181 – 211314Fe-4S ferredoxin-type 2
Region252 – 984733Formate dehydrogenase

Sites

Metal binding371Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding481Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding511Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding631Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding951Iron-sulfur 2 (4Fe-4S); via tele nitrogen By similarity
Metal binding991Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1021Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1091Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1471Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1501Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1531Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1571Iron-sulfur 4 (4Fe-4S) By similarity
Metal binding1901Iron-sulfur 4 (4Fe-4S) By similarity
Metal binding1931Iron-sulfur 4 (4Fe-4S) By similarity
Metal binding1961Iron-sulfur 4 (4Fe-4S) By similarity
Metal binding2001Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding2641Iron-sulfur 5 (4Fe-4S) By similarity
Metal binding2671Iron-sulfur 5 (4Fe-4S) By similarity
Metal binding2711Iron-sulfur 5 (4Fe-4S) By similarity
Metal binding2991Iron-sulfur 5 (4Fe-4S) By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q49ZN0-1 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 8F9B3434353CA9EF

FASTA984111,049
        10         20         30         40         50         60 
MQEHLIVSLD GKDYLVEPGT NLLQFIKSQD TFVPSICYNE SLGPIQTCDT CTVEIDGKME 

        70         80         90        100        110        120 
RACSTTIDRP MIVNTQNDKV QASQKEALDR ILEKHMLYCT VCDYNNGDCE IHNTMDQWGL 

       130        140        150        160        170        180 
EHQTYEYKEK PYEKDYGPFY RYDPNQCILC GRCVEVCQDV QVNETLTIDW ERQQPRVIWD 

       190        200        210        220        230        240 
NDTSINDSSC VGCGQCATVC PCNAMLEVNM EGNAGYMTDL EPGSLAAMID LTKKAEPGYG 

       250        260        270        280        290        300 
PLFAVSDSEA AMREERIEKT KTVCTYCGVG CSFDVWTKNR EVLKVQPQHE SPANKISSCV 

       310        320        330        340        350        360 
KGKFGWDYVD SDERLTKPLV RKNGQFEEVE WEEALSVVAE NFNKVKGTHG SDGLAFISSS 

       370        380        390        400        410        420 
KATNEESYLM QKLARQVIGT NNVDNCSRYC QAPATKGLFR TVGHGGDSGS IEDLEIADMV 

       430        440        450        460        470        480 
VLIGTNTAEA HPVIASRIKR GHKLYNNTLN VFDIRKHEMA ERADNFYQPK PGTDLVWLSA 

       490        500        510        520        530        540 
VTKYIIDEDL HDKAFINEWV NHFDEYYKSL APYTMEFAEE TTGISKDALI DFAHQVADAK 

       550        560        570        580        590        600 
SVSIAWAMGV TQQDIGSDTS TAISNLLLAT GNYRKPGSGA YPLRGHNNVQ GCSDMGSMPD 

       610        620        630        640        650        660 
QFPGYQKVTD DEIRAKFERE YGETLPKQVG KDNHQMMEGI HNGEIDSLYL YGEDTGIVDS 

       670        680        690        700        710        720 
NINFVQAALE KVGFLVVQDE FFTFTATYAD VVLPASPSLE KTGTFTNTER RIQRLFQALE 

       730        740        750        760        770        780 
PKGDSKPDWQ IIQAVAKAMG YDWNYTHPSQ IMDEIARLTP LYSGVNYDRL EGYNSLQWPV 

       790        800        810        820        830        840 
AEDGTDEPIL YLEGFNFEDK KANFYPLTFD NFFKVNEEYD LHVNNGRLLE HFHEGNMTYK 

       850        860        870        880        890        900 
VPGLEYKVPN AFVEVSPELA EDRGIHEGAE IKLISETGEV ELVAHVTDRV KGKEIYIPLN 

       910        920        930        940        950        960 
NNAMAHGDHG AINLLTNSDV DKDTDTPSYK RTSCRMEVKT RRGKSPLNPT NFRVNKQRQP 

       970        980 
QYSVRVQDKW KREDYTFPGS QVDR

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References

[1]"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed: 16135568] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

AP008934 Genomic DNA. Translation: BAE17746.1.
RefSeqYP_300691.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3616095.
GenomeReviewsGene locus SSP0601 in contig AP008934_GR.
KEGGssp:SSP0601.
NMPDRfig|342451.4.peg.780.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ49ZN0.

Enzyme and pathway databases

BioCycSSAP342451:SSP0601-MON.

Family and domain databases

InterProIPR001450. 4Fe4S_Fe_S_bd.
IPR009010. Asp_de-COase-like_fold.
IPR001041. Ferredoxin.
IPR006478. Formate_DHase_asu.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_Fe4S4.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR006657. MPT_dinuc_bd.
[Graphical view]
Gene3DG3DSA:2.40.40.20. Asp_decarboxylase-like_fold. 1 hit.
PfamPF00111. Fer2. 1 hit.
PF00037. Fer4. 2 hits.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
[Graphical view]
PRINTSPR00353. 4FE4SFRDOXIN.
TIGRFAMsTIGR01591. Fdh-alpha. 1 hit.
PROSITEPS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00490. MOLYBDOPTERIN_PROK_2. False negative.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
[Graphical view]
ProDomQ49ZN0.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameFDHL_STAS1
AccessionPrimary (citable) accession number: Q49ZN0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 13, 2005
Last modified: September 2, 2008
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents