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Reviewed, UniProtKB/Swiss-Prot Q4L8G8 (FDHL_STAHJ)

Last modified July 22, 2008. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Putative formate dehydrogenase SH0748
    EC=1.2.1.2
Gene names
Ordered Locus Names: SH0748
OrganismStaphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]
Taxonomic identifier279808 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

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Protein attributes

Sequence length984 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

Formate + NAD(+) = CO(2) + NADH.

Cofactor

Binds 1 2Fe-2S cluster By similarity.

Binds 4 4Fe-4S clusters By similarity.

Molybdenum (molybdopterin) By similarity.

Sequence similarities

In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 2 4Fe-4S ferredoxin-type domains.

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Ontologies

Keywords

   DomainRepeat
   Ligand2Fe-2S
4Fe-4S
Iron
Iron-sulfur
Metal-binding
Molybdenum
NAD
   Molecular functionOxidoreductase
   Technical termComplete proteome

Gene Ontology (GO)

None. [Check GOA]

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 984984Putative formate dehydrogenase SH0748

Regions

Domain3 – 79772Fe-2S ferredoxin-type
Domain138 – 165284Fe-4S ferredoxin-type 1
Domain181 – 211314Fe-4S ferredoxin-type 2
Region252 – 984733Formate dehydrogenase

Sites

Metal binding371Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding481Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding511Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding631Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding951Iron-sulfur 2 (4Fe-4S) (via tele nitrogen) By similarity
Metal binding991Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1021Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1091Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1471Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1501Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1531Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1571Iron-sulfur 4 (4Fe-4S) By similarity
Metal binding1901Iron-sulfur 4 (4Fe-4S) By similarity
Metal binding1931Iron-sulfur 4 (4Fe-4S) By similarity
Metal binding1961Iron-sulfur 4 (4Fe-4S) By similarity
Metal binding2001Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding2641Iron-sulfur 5 (4Fe-4S) By similarity
Metal binding2671Iron-sulfur 5 (4Fe-4S) By similarity
Metal binding2711Iron-sulfur 5 (4Fe-4S) By similarity
Metal binding2991Iron-sulfur 5 (4Fe-4S) By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q4L8G8-1 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: F0CCF0467C86D89F

FASTA984110,941
        10         20         30         40         50         60 
MQEHLIVTLD GTDYLVEPGT SLLEFIKSRD TFVPSICYNE SMGPIQTCDT CMVEIDGKIE 

        70         80         90        100        110        120 
RACSTVVNRP MTVNTQNNDV KASQKEALDR ILEKHMLYCT VCDYNNGDCE IHNAMDAWGL 

       130        140        150        160        170        180 
EEQSYEYKTK PYEKDYGPFY RYDPDQCILC GRCVEACQDI EVNETISIDW NREHPRVIWD 

       190        200        210        220        230        240 
NDVPINESSC VSCGQCATVC PCNAMMEVNM EGNAGYMTDT EPGSLAAMID LTKKAEPGDG 

       250        260        270        280        290        300 
LLFAVSDSEA EMRKERIKKT KTVCTYCGVG CSFDVWTKDR EVLKVQPSHD SPANKIATCV 

       310        320        330        340        350        360 
KGKFSWGHIN SDQRLTKPLV RKDGEFHEVE WDEALDVIET NFKRIKNEYG GDHLAFIASS 

       370        380        390        400        410        420 
KGTNEESYLM QKLSRQVFGS NNVDNCSRYC QAPATKGLFR TVGHGGDSGS IEDLERAAMT 

       430        440        450        460        470        480 
VLIGTNTAEA HPVIASRMKR AQKLFGQKMH VFDIRKHEMA ARADAFYQPK PGTDLVWLGA 

       490        500        510        520        530        540 
ATKYIIDNDL HDKAFLNDWV DNYEDYYKSL ELFTMDFAEE TTGIPKEQII SFAEEAAKAE 

       550        560        570        580        590        600 
SMSICWAMGV TQQDIGSDTS TAISNLLLVT GNYRKPGSGA YPLRGHNNVQ GASDMGSMPD 

       610        620        630        640        650        660 
QFPGYQKVAD DEVRAKFEKE YGVELNPTPG RDNHQMMEGI HNGDIQSLYL YGEDTGIVDS 

       670        680        690        700        710        720 
NINFVQSALE KVDFLVVQDE FLTFTATYAD VVLPASPSLE KDGTFTNTER RIQRINKALQ 

       730        740        750        760        770        780 
PLGDSKPDWE IFQLIAQRMG ADWNYKHPSE IMDEIAGLTP SYSGVNYERL QGFNSLQWPV 

       790        800        810        820        830        840 
APDGTDQPTL YMDGFNFENG RAKLFPLTFD NFFKEDEVYD LHVNNGRLLE HFHEGNMTYQ 

       850        860        870        880        890        900 
TEMIKYKVPN AFVEISPELA KDRDIHEGAE LRLISETGEA TLIATVTDRV KGREIYIPLN 

       910        920        930        940        950        960 
NDAMSNGDLG AINKLTNSDV DKYTDTPSYK RTSCRMEVLT RKGKSPLNPT NFRVDKQRNP 

       970        980 
QYSVQVQKKW ERPDYVFPGN VVDK

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References

[1]"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
J. Bacteriol. 187:7292-7308(2005) [PubMed: 16237012] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

AP006716 Genomic DNA. Translation: BAE04057.1.
RefSeqYP_252663.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3483766.
GenomeReviewsGene locus SH0748 in contig AP006716_GR.
KEGGsha:SH0748.
NMPDRfig|279808.3.peg.381.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ4L8G8.

Enzyme and pathway databases

BioCycSHAE279808:SH0748-MON.

Family and domain databases

InterProIPR001450. 4Fe4S_Fe_S_bd.
IPR009010. Asp_de-COase-like_fold.
IPR001041. Ferredoxin.
IPR006478. Formate_DHase_asu.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_Fe4S4.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR006657. MPT_dinuc_bd.
[Graphical view]
Gene3DG3DSA:2.40.40.20. Asp_decarboxylase-like_fold. 1 hit.
PfamPF00111. Fer2. 1 hit.
PF00037. Fer4. 2 hits.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
[Graphical view]
PRINTSPR00353. 4FE4SFRDOXIN.
TIGRFAMsTIGR01591. Fdh-alpha. 1 hit.
PROSITEPS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00490. MOLYBDOPTERIN_PROK_2. False negative.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
[Graphical view]
ProDomQ4L8G8.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameFDHL_STAHJ
AccessionPrimary (citable) accession number: Q4L8G8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: August 2, 2005
Last modified: July 22, 2008
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents