Reviewed, UniProtKB/Swiss-Prot Q4UN77 (PGSA_RICFE)

Names and origin

Protein names

Recommended name:
    CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
    EC=2.7.8.5
Alternative name(s):
    Phosphatidylglycerophosphate synthase
      Short name=PGP synthase

Gene names

Name:	pgsA
Ordered Locus Names:	RF_0130

Organism

Rickettsia felis (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

42862 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This protein catalyzes the committed step to the synthesis of the acidic phospholipids By similarity.
Catalytic activity	CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.
Pathway	Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
Subcellular location	Cell membrane; Multi-pass membrane proteinBy similarity.
Sequence similarities	Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 181	181	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase		PRO_0000281054
Regions
	Transmembrane	8 – 28	21	Potential
	Transmembrane	35 – 55	21	Potential
	Transmembrane	64 – 84	21	Potential
	Transmembrane	148 – 168	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q4UN77-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 6883E9F59EF93E02	FASTA	181	20,341
	10 20 30 40 50 60 MRIDKNLPNY LTIARIMVIP VIILAFYINN SLARKLGALL FVLASITDFF DGYIARKYNL 70 80 90 100 110 120 VTSFGKMFDP IADKLLIGCV IIMLLKKDNV DEIPCLLILA REFLVSGLRE FLALVKVSVP 130 140 150 160 170 180 VSRLAKVKTF LQMFALSILI LGSKGSGIIY LDIVGEIILW IAAFLTIITG YSYFKACKKY F

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed: 15984913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000053 Genomic DNA. Translation: AAY60981.1.
RefSeq	YP_246146.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3400841.
GenomeReviews	Gene locus RF_0130 in contig CP000053_GR.
KEGG	rfe:RF_0130.
NMPDR	fig|315456.3.peg.649.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4UN77.
Enzyme and pathway databases
BioCyc	RFEL315456:RF_0130-MON.
Family and domain databases
InterPro	IPR000462. CDP-OH_P_trans. IPR004570. Phosphatidylglycerol_P_synth. [Graphical view]
Pfam	PF01066. CDP-OH_P_transf. 1 hit. [Graphical view]
PIRSF	PIRSF000847. Phos_ph_gly_syn. 1 hit.
TIGRFAMs	TIGR00560. pgsA. 1 hit.
PROSITE	PS00379. CDP_ALCOHOL_P_TRANSF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGSA_RICFE

Accession

Primary (citable) accession number: Q4UN77

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	July 5, 2005
Last modified:	November 25, 2008
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)