Reviewed, UniProtKB/Swiss-Prot Q4UN98 (SYR_RICFE)

Names and origin

Protein names

Recommended name:
    Arginyl-tRNA synthetase
    EC=6.1.1.19
Alternative name(s):
    Arginine--tRNA ligase
      Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	RF_0109

Organism

Rickettsia felis (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

42862 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	576 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm. HAMAP MF_00123
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP arginine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 576	576	Arginyl-tRNA synthetase HAMAP MF_00123		PRO_0000242084
Regions
	Motif	126 – 136	11	"HIGH" region HAMAP MF_00123

Sequences

	Sequence		Length	Mass (Da)
	Q4UN98-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: EBB594C13F910560	FASTA	576	65,157
	10 20 30 40 50 60 MNIFNQLKQD IIAASKQLYN NQEIANTANI ETPKDNFNGD LSSNIAMIIA AKESISPREV 70 80 90 100 110 120 ALKFKEVLTT LPYIASIEIA GPGFINFTIK AESWQASIKD ILQHEEKFFE IDIDKSRNIN 130 140 150 160 170 180 IEYVSANPTG PMHIGHARGA VYGDVLARIL QKVGYSVTKE YYVNDAGSQI NDLVSTVLLR 190 200 210 220 230 240 YREALGEKIT IPAGLYPGEY LIPLGQILAK EYGNKLLTMN ENERFKIVKN FAVEKMLDLN 250 260 270 280 290 300 RKDLADLGIK HDIFFSEQSL HDKGEIEGTV KLLTGMGLIY EGTLPAPKGK VHEEWDNRVQ 310 320 330 340 350 360 KLFKSTNYGD SQDRPIEKAD GSWSYFASDL AYAKDKIDRG ANHLIYVLGA DHSGYVKRIE 370 380 390 400 410 420 AIVKALGKEQ VKVDVKICQL VNFVENGVPV KMSKRLGNFA SVQDVNHEVG KDIIRFMMLT 430 440 450 460 470 480 RQNDKPLDFD LVKVKEQSRE NPIFYVQYAH VRTISILSKA RELMPESYNN FEEGKYDLSL 490 500 510 520 530 540 LSSEEEIEII KLLASWTKTL EASAKYFEPH RIAFYLINLA SRFHSMWNFG KENSDYRFVI 550 560 570 ESNKELTLAR LALASAIQKV IASGLEVIGV EPMDRM

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed: 15984913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000053 Genomic DNA. Translation: AAY60960.1.
RefSeq	YP_246125.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3401078.
GenomeReviews	Gene locus RF_0109 in contig CP000053_GR.
KEGG	rfe:RF_0109.
NMPDR	fig|315456.3.peg.628.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4UN98.
Enzyme and pathway databases
BioCyc	RFEL315456:RF_0109-MON.
Family and domain databases
HAMAP	MF_00123. [Tree]
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ic. IPR015945. Arg-tRNA-synth_Ic_core. IPR005148. Arg-tRNA-synth_Ic_N. IPR008909. DALR_anticod_bd. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
TIGRFAMs	TIGR00456. argS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_RICFE

Accession

Primary (citable) accession number: Q4UN98

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	July 5, 2005
Last modified:	July 22, 2008
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)