Reviewed, UniProtKB/Swiss-Prot Q54699 (HYLP2_BPH45)

Names and origin

Protein names

Recommended name:
    Hyaluronoglucosaminidase
      Short name=Hyaluronidase
    EC=3.2.1.35

Gene names

Name:

HYLP2

Organism

Streptococcus pyogenes phage H10403

Taxonomic identifier

86065 [NCBI]

Taxonomic lineage

Viruses

Virus host

Streptococcus pyogenes [TaxID: 1314]

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The hyaluronidase of this bacteriophage mediates the penetration of the hyaluronic capsule of Streptococcus pyogenes.
Catalytic activity	Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
Sequence similarities	Belongs to the glycosyl hydrolase 69 family.

Ontologies

Keywords
Molecular function	Glycosidase Hydrolase
Gene Ontology (GO)
Biological process	capsule polysaccharide biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	hyalurononglucosaminidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Hyaluronoglucosaminidase		PRO_0000057724

Sequences

	Sequence		Length	Mass (Da)
	Q54699-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 770EB8E6B7F9D842	FASTA	337	36,453
	10 20 30 40 50 60 MSENIPLRVQ FKRMKAAEWA RSDVILLESE IGFETDTGFA RAGDGHNRFS DLGYISPLDY 70 80 90 100 110 120 NLLTNKPNID GLATKVETAQ KLQQKADKET VYTKAESKQE LDKKLNLKGG VMTGQLKFKP 130 140 150 160 170 180 AATVAYSSST GGAVNIDLSS TRGAGVVVYS DNDTSDGPLM SLRTGKETFN QSALFVDYKG 190 200 210 220 230 240 TTNAVNIAMR HATTPNFSSA LNITSGNENG SAMQLRGSEK ALGTLKITHE NPSIGADYDK 250 260 270 280 290 300 NAARYPLILS KRQNGAGTAA QGIYINSTSG TTGKLLRIRN LSDDKFYVKS DGGFYAKETS 310 320 330 QIDGNLKLKD PTANDHAATK AYVDKAISEL KKLILKK

References

[1]

"Analysis of a second bacteriophage hyaluronidase gene from Streptococcus pyogenes: evidence for a third hyaluronidase involved in extracellular enzymatic activity." Hynes W.L., Hancock L., Ferretti J.J. Infect. Immun. 63:3015-3020(1995) [PubMed: 7622224] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U28144 Genomic DNA. Translation: AAA86895.1.
3D structure databases
SMR	Q54699. Positions 7-337.
ModBase	Search...
Family and domain databases
InterPro	IPR009860. Hyaluronidase_bac. [Graphical view]
Pfam	PF07212. Hyaluronidase_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HYLP2_BPH45

Accession

Primary (citable) accession number: Q54699

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	November 25, 2008
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)