Reviewed, UniProtKB/Swiss-Prot Q54B82 (CSN4_DICDI)

Names and origin

Protein names

Recommended name:
    COP9 signalosome complex subunit 4
      Short name=Signalosome subunit 4

Gene names

Name:	csn4
ORF Names:	DDB_0233102

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	393 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity.
Subunit structure	Component of the CSN complex. The holocomplex is comprised of 8 subunits csn1-8. In the complex, it probably interacts directly with csn1, csn2, csn3, csn4, csn6 and csn8.
Subcellular location	CytoplasmBy similarity. NucleusBy similarity.
Sequence similarities	Belongs to the CSN4 family. Contains 1 PCI domain.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus Signalosome
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	signalosome Ref.1 Inferred from physical interaction. Source: dictyBase
Molecular function	protein binding Ref.1 Inferred from physical interaction. Source: dictyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 393	393	COP9 signalosome complex subunit 4
Regions
	Domain	260 – 359	100	PCI
	Compositional bias	154 – 157	4	Poly-Glu

Sequences

	Sequence		Length	Mass (Da)
	Q54B82-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 515CD343FD8D5339	FASTA	393	45,383
	10 20 30 40 50 60 MDVNNLKQIL EETSALSDHK TKTEKYKSIL QQLVESKQVA PLKVFITHLT DESTPLVISR 70 80 90 100 110 120 TILLSFTSSH KTLPEDIQME LGIFVLDRIQ NRVVAFEEQV SEIRYNLAKL YERQENWRES 130 140 150 160 170 180 ARCLIAIPLD SSQRVISPEY KVKIYVKIAR LFLEEEESGQ AETYINRASD SLHLVKNQKL 190 200 210 220 230 240 ILAHKTCFAR IMDYKRMFLK ASLRYYDLSQ CLPKDTERMH ALSCAIVCAI LDKAGPQRSR 250 260 270 280 290 300 TLATLYKDER SQQLGVYTFL EKMFLERILK KTEVKKFAEQ LKPHQMALLS DGNTVLDRAV 310 320 330 340 350 360 IEHNLLSASK LYNNITFDEL GSLLEIQAEK AEKVASKMVC EERLIGSIDQ IERLIQFENV 370 380 390 GDSLTQWDKK IEGLCIHMNN IIESISKYPE FIV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The COP9 signalosome regulates cell proliferation of Dictyostelium discoideum." Rosel D., Kimmel A.R. Eur. J. Cell Biol. 85:1023-1034(2006) [PubMed: 16781008] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: AX3.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ309432 mRNA. Translation: ABC46696.1. AAFI02000222 Genomic DNA. Translation: EAL60525.1.
RefSeq	XP_628938.1.
3D structure databases
SMR	Q54B82. Positions 295-358.
ModBase	Search...
Genome annotation databases
GeneID	3385602.
KEGG	ddi:DDB_0233102.
Organism-specific databases
dictyBase	DDB0233102. csn4.
Family and domain databases
InterPro	IPR000717. PCI. IPR011991. Wing_hlx_DNA_bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
Pfam	PF01399. PCI. 1 hit. [Graphical view]
SMART	SM00088. PINT. 1 hit. [Graphical view]
ProDom	Q54B82. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

CSN4_DICDI

Accession

Primary (citable) accession number: Q54B82
Secondary accession number(s): Q2PQ75

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	July 22, 2008
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)