Reviewed, UniProtKB/Swiss-Prot Q54BM2 (PABPB_DICDI)

Names and origin

Protein names

Recommended name:
    Polyadenylate-binding protein 1-B
      Short name=Poly(A)-binding protein 1-B
      Short name=PABP 1-B

Gene names

Name:	pabpB
ORF Names:	DDB_0233359

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	565 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation By similarity.
Subcellular location	CytoplasmBy similarity. NucleusBy similarity.
Sequence similarities	Belongs to the polyadenylate-binding protein type-1 family. Contains 1 PABC domain. Contains 4 RRM (RNA recognition motif) domains.

Ontologies

Keywords
Biological process	mRNA processing
Cellular component	Cytoplasm Nucleus
Domain	Repeat
Ligand	RNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	phagocytic vesicle Ref.2 Inferred from direct assay. Source: dictyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 565	565	Polyadenylate-binding protein 1-B
Regions
	Domain	10 – 88	79	RRM 1
	Domain	98 – 175	78	RRM 2
	Domain	188 – 265	78	RRM 3
	Domain	284 – 362	79	RRM 4
	Domain	489 – 565	77	PABC

Sequences

	Sequence		Length	Mass (Da)
	Q54BM2-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 40D8D884F58E3ED8	FASTA	565	62,780
	10 20 30 40 50 60 MATNFTPISS SLYVGDLLPE VSEQHLFEIF NQVGLVSNIR VCRDTNTRRS LSYAYVNYYN 70 80 90 100 110 120 GADAERALDT LNNTPIRGKA CRIMWSQRDP SLRKSGVGNV FIKNLDKGID HKALYDTFSA 130 140 150 160 170 180 FGNILSCKVV TDDGNSSKGF GFVHYETQES ADKAIAKVNG MMINGQKVFV GPFKSSKERG 190 200 210 220 230 240 QPTEVKFTNV FFKNLSEDVG PDQLKELLQQ YGEITNITIM ADDKGKSKGF GFANFESAEA 250 260 270 280 290 300 AKNVVENENG KIFHGKPIYA GRAQKKIERE AELKHTFETK YQGVNLYIKN IDDSIDNDKL 310 320 330 340 350 360 REVFSQFGTI TSAIVMKDDK ATTSKGFGFV CYTAPDEATR AVTEMNGRMI GTKPLYVALA 370 380 390 400 410 420 QRKDIRRAQL EMQHQQKFKT GIRQQMPPTY GSGPVFFTPA PVNPQVVYQQ MMPRPRNWNG 430 440 450 460 470 480 QPVGVPQGQY ANMNYARGQP RQNGPRQNGG QPRQNGPRPD VSGAQPIPVQ QQTTLDVAQT 490 500 510 520 530 540 QQAASSAESA LNLQSIINLP SRDQQNVALG EHLYPLIHNS QPDLAGKITG MLLDSLPVEE 550 560 LFTLTQRQDL LADKIREALE VLGSN

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

[2]

"Proteomics fingerprinting of phagosome maturation and evidence for the role of a Galpha during uptake." Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M., Soldati T. Mol. Cell. Proteomics 5:2228-2243(2006) [PubMed: 16926386] [Abstract] Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000218 Genomic DNA. Translation: EAL60591.1.
RefSeq	XP_629007.1.
3D structure databases
SMR	Q54BM2. Positions 10-179.
ModBase	Search...
Genome annotation databases
GeneID	3385676.
KEGG	ddi:DDB_0233359.
Organism-specific databases
dictyBase	DDB0233359. pabp1B.
Family and domain databases
InterPro	IPR012677. a_b_plait_nuc_bd. IPR006515. PABP_1234. IPR002004. PABP_HYD. IPR000504. RRM_RNP1. [Graphical view]
Gene3D	G3DSA:3.30.70.330. a_b_plait_nuc_bd. 4 hits. G3DSA:1.10.1900.10. PABP_HYD. 1 hit.
Pfam	PF00658. PABP. 1 hit. PF00076. RRM_1. 4 hits. [Graphical view]
SMART	SM00360. RRM. 4 hits. [Graphical view]
TIGRFAMs	TIGR01628. PABP-1234. 1 hit.
PROSITE	PS51309. PABC. 1 hit. PS50102. RRM. 4 hits. [Graphical view]
ProDom	Q54BM2. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

PABPB_DICDI

Accession

Primary (citable) accession number: Q54BM2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	September 23, 2008
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)