Reviewed, UniProtKB/Swiss-Prot Q54GQ6 (ACOX1_DICDI)

Names and origin

Protein names

Recommended name:
    Peroxisomal acyl-coenzyme A oxidase 1
    EC=1.3.3.6

Gene names

Name:	acox1
ORF Names:	DDB_0234154

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	700 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs By similarity.
Catalytic activity	Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2).
Cofactor	FAD By similarity.
Subcellular location	PeroxisomeBy similarity.
Sequence similarities	Belongs to the acyl-CoA oxidase family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Peroxisome
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 700	700	Peroxisomal acyl-coenzyme A oxidase 1
Regions
	Nucleotide binding	412 – 417	6	FAD By similarity
	Motif	698 – 700	3	Microbody targeting signal Potential
	Compositional bias	461 – 464	4	Poly-Gly

Sequences

	Sequence		Length	Mass (Da)
	Q54GQ6-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 3F286207CFD33958	FASTA	700	79,762
	10 20 30 40 50 60 MYCPKAYENE KKNEDLEFER SQSTFSVSEL NFILNNNDHN IINIKNEIKK FIDNDEIISK 70 80 90 100 110 120 PQEIHFLSRE EQYKRALYVS SKLIEIKKRF GEIGRDQYYQ SLFEEIPFVI NDIVFACAFK 130 140 150 160 170 180 SLASDEQMNR LYSKFENYQY FGSYSQTEIG HGSNVQGIET TCTFIKETGE FELNSPNLTS 190 200 210 220 230 240 TKFWIGGLGK LATHTIVFAQ LLIPSSIDGK LKNYGPHPFI LQVRSLDDHS PLPGVTVGDI 250 260 270 280 290 300 GPKLGFNSID NGFLRLDHVR IPRENMLSRF FRVNEQGEYE KPKHPKLIYA GMVGVRSSMI 310 320 330 340 350 360 ENSFVSLSRA VTIAIRYSTI RKQFKSNRLD KQEKKIIEYS NQMNRIIPYL AQTFAYFFTG 370 380 390 400 410 420 KRFSIEFDQM MKAVKHNQDT TLLSELHANS SGLKSLMTQS TSDGIESCRL SCGGHGYSQF 430 440 450 460 470 480 SGLPYLWSNY VHMSSAEGES NLLPQQTTKY LLTILRKVLS GGGGSSDTTT ADDDNKPIGK 490 500 510 520 530 540 SVKYINDEFQ SSFENINQFI QEKGLNSIIH PDSLLQLFKH RSFILIKSIA ESIQEQMSNG 550 560 570 580 590 600 NKDIPQIWSD LNVEINHCSK AHCQLYVIQS FYDQILLLSS NSSSCSSSIT TVLIQLLQTY 610 620 630 640 650 660 SIWIINSNLV DFLQDQYVEL SQIDFLKKSL INFYKLLRPN LVPLVDSFDL CNTTLGSALG 670 680 690 700 SYNGDVYSTL YKWASTQPFN KNSLPLGFNE TIKPLINSKL

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000150 Genomic DNA. Translation: EAL62442.1.
RefSeq	XP_635946.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3387519.
KEGG	ddi:DDB_0234154.
Organism-specific databases
dictyBase	DDB0234154. acox1.
Family and domain databases
InterPro	IPR006091. Acyl-CoA_DHase/Oxase_M. IPR012258. Acyl-CoA_oxidase. IPR002655. Acyl_CoA_ox_C. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 2 hits.
PANTHER	PTHR10909:SF11. Acyl-CoA_oxidase. 1 hit.
Pfam	PF01756. ACOX. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. [Graphical view]
PIRSF	PIRSF000168. Acyl-CoA_oxidase. 1 hit.
ProDom	Q54GQ6. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ACOX1_DICDI

Accession

Primary (citable) accession number: Q54GQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	May 24, 2005
Last modified:	September 2, 2008
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)